Difference between revisions of "Placenta"

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The '''placenta''' feeds the developing baby, breathes for it and disposes of its waste.
[[Image:Human_placenta.jpg|thumb|right|A placenta (fetal aspect) with attached umbilical cord. (WC/Asturnut)]]
The '''placenta''' feeds the developing baby, breathes for it and disposes of its waste.  


==Normal==
The organ is one that seems to be left behind; at least one review suggests it isn't done so well by general pathologists.<ref name=pmid12033960>{{Cite journal  | last1 = Sun | first1 = CC. | last2 = Revell | first2 = VO. | last3 = Belli | first3 = AJ. | last4 = Viscardi | first4 = RM. | title = Discrepancy in pathologic diagnosis of placental lesions. | journal = Arch Pathol Lab Med | volume = 126 | issue = 6 | pages = 706-9 | month = Jun | year = 2002 | doi = 10.1043/0003-9985(2002)1260706:DIPDOP2.0.CO;2 | PMID = 12033960 }}</ref>
Amnion - next to fetus, surrounds amniotic fluid, avascular.
 
*Characterized by a single layer of cells.<ref>Sternberg. Histo. for Pathol. 2nd Ed. P.974</ref>
''Placental pathology'' redirects to this article.
 
=Clinical=
==Examination of the placenta==
*Most placentas are ''not'' examined by a pathologist.
 
===Indications for exam by pathology===
Some indications for exam by a pathologist:
*Abnormalities in the:
*#Fetus:
*#*Bad fetal outcome.
*#*Suspected or known congenital abnormalities ''or'' chromosomal abnormalities.
*#*[[IUGR]].
*#Mother:
*#*Infection/suspected infection.
*#*Pre-term labour.
*#*Maternal disease (e.g. [[SLE]], coagulopathy).
*#*Complicated pregnancy (preclampsia, pregnancy induced hypertension, gestational diabetes).
*#Placenta:
*#*Unusual gross characteristics.<ref name=pmid9518951>{{cite journal |author=Yetter JF |title=Examination of the placenta |journal=Am Fam Physician |volume=57 |issue=5 |pages=1045–54 |year=1998 |month=March |pmid=9518951 |doi= |url=}}</ref>
 
A more detailed list is given by Hargitai et al.<ref name=pmid15280396>{{cite journal |author=Hargitai B, Marton T, Cox PM |title=Best practice no 178. Examination of the human placenta |journal=J. Clin. Pathol. |volume=57 |issue=8 |pages=785–92 |year=2004 |month=August |pmid=15280396 |pmc=1770400 |doi=10.1136/jcp.2003.014217 |url=}}</ref> and Chang.<ref>URL: [http://smj.sma.org.sg/5012/5012ra1.pdf http://smj.sma.org.sg/5012/5012ra1.pdf]. Accessed on: 11 February 2011.</ref>
 
====Most common====
Most common reasons for submitting a placenta to pathology:<ref>Sherman C. 8 February 2011.</ref>
# Prematurity.
# PROM / possible [[chorioamnionitis]].
# Multiple gestation.
 
==Bleeding in late pregnancy==
DDx of bleeding in late pregnancy:
*[[Placental abruption]] (most common).
*Placenta previa.
*Vasa previa (fetus losing blood).
 
==Clinical screening tests==
{{main|Pregnancy}}
*PAPP-A - low values seen in aneuploidy.<ref>URL: [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069]. Accessed on: 7 July 2010.</ref>
 
==Abbreviations==
*C/S = Caesarean section.
*LSCS = lower segment C-section.
*FTP = failure to progress.
*PROM = premature rupture of membranes.
*PPROM = preterm premature ruptures of membranes.
*IUGR = [[intrauterine growth restriction]].
*IOL = induction of labour.
 
=Normal histology=
==Villi==
{{Main|Chorionic villi}}
This is dealt with in a separate article that also covers the types of trophoblast ([[cytotrophoblast]], [[syncytiotrophoblast]], intermediate trophoblast).
 
==Cord==
===Omphalomesenteric duct remnant===
*[[AKA]] vitelline duct.
*Benign embryologic remnant.
 
Features:
*Duct with benign looking cuboidal epithelium.
 
===Allantoic duct remnant===
*Benign embryologic remnant.
 
Features:
*Duct with benign looking flat epithelium.
 
===Vitelline artery remnant===
Features:
*Small artery in the cord.
 
==Membranes==
Fetus to mother:
*Amnion - thin layer: one cell layer, basement membrane, connective tissue.
*Cleft - artifactual - empty space.
*Chorion - vascular.
*Decidua (maternal tissue) - may contain obsolete chorionic villi; place to look for hypertensive changes.
 
===Amnion===
General:
*Next to fetus, surrounds amniotic fluid, avascular.
 
Characteristics:
*Characterized by a single layer of cells.<ref name=Ref_H4P2_974>{{Ref H4P2|974}}</ref>
**Cuboidal/squamoid shape.
**Cuboidal/squamoid shape.
**Eosinophilic cytoplasm.
**Eosinophilic cytoplasm.
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*Squamous metaplasia may be seen at cord insertion.
*Squamous metaplasia may be seen at cord insertion.
*Basement membrane.
*Basement membrane.
*'Compact layer'.<ref>H4P 2nd Ed., P.974.</ref>
*'Compact layer'.<ref name=Ref_H4P2_974>{{Ref H4P2|974}}</ref>
*'Fibroblastic layer'.<ref>H4P 2nd Ed., P.974.</ref>
*'Fibroblastic layer'.<ref name=Ref_H4P2_974>{{Ref H4P2|974}}</ref>


Chorion - surrounds amnion
===Chorion===
*Layers:<ref>H4P 2nd Ed., P.977.</ref>
General:
*Surrounds amnion.
 
Characteristics:
*Layers:<ref name=Ref_H4P2_977>{{Ref H4P2|977}}</ref>
**'Reticular layer' - cellular (inner aspect).
**'Reticular layer' - cellular (inner aspect).
**'Pseudo-basemement membrane'.
**'Pseudo-basemement membrane'.
**'Outer trophoblastic layer'.
**'Outer trophoblastic layer'.
*Has blood vessels.
*Has blood vessels.
*Opposed to "trophoblastic X cells" on side opposite of amnion.<ref>H4P 2nd Ed., P.974.</ref>
*Opposed to "trophoblastic X cells" on side opposite of amnion.<ref name=Ref_H4P2_974>{{Ref H4P2|974}}</ref>
**Beneath of the "trophoblastic X cells" is ''decidua'' (mnemonic ''NEW'' = nucleus central, eosinophilic, well-defined cell border), which is maternal tissue.  
**Beneath of the "trophoblastic X cells" is ''decidua'' (mnemonic ''NEW'' = nucleus central, eosinophilic, well-defined cell border), which is maternal tissue.
 
Note:
*Fibrin deposition may be found deep to the chorion - known as ''subchorionic fibrin deposition''.
**Gross: subchorionic, white/yellow, laminated, classically has a triangular-shape with the base of triangle parallel to fetal aspect of disc.
***Arises due to localized stasis of the inter-villous maternal blood.
**Focal small deposits are considered to be a normal finding - seen in ~15% of cases.<ref name=pmid21393870>{{Cite journal  | last1 = Narasimha | first1 = A. | last2 = Vasudeva | first2 = DS. | title = Spectrum of changes in placenta in toxemia of pregnancy. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 15-20 | month =  | year =  | doi = 10.4103/0377-4929.77317 | PMID = 21393870 |URL = http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=15;epage=20;aulast=Narasimha }}</ref><ref>URL: [http://zulekhahospitals.com/uploads/files/Sub-chorionic.pdf http://zulekhahospitals.com/uploads/files/Sub-chorionic.pdf]. Accessed on: 17 August 2012.</ref>
***The pathologic counterpart of this is ''[[perivillous fibrin deposition]]''.
 
Image:
*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2011_54_1_15_77317_u5.jpg Subchorionic fibrin deposition (ijpmonline.org)].


===Additional terms===
==Common terms==
*Chorionic plate - fetal aspect of placenta.
*Chorionic plate - fetal aspect of placenta.
*Basal plate - maternal aspect of placenta.
*Basal plate - maternal aspect of placenta.
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**Place to look for maternal vessels.
**Place to look for maternal vessels.


==Grossing==
=Grossing=
This is often very quick.  The gross is quite important, as some things cannot be diagnosed microscopically.
==General==
*Dimensions:
*Dimensions:
**Disc.  
**Disc.  
**Length of cord, diameter of cord.
**Length of cord, diameter of cord.
*Mass (weight) -- should be done 'trimmed' (cord cut-off, membrane cut-off).
**Accessory lobes - dimensions.
***Two lobes of equal size + cord arises in between = bilobate placenta.
*Mass (weight).
**Should be done 'trimmed' (cord cut-off, membrane cut-off).
**Should be done when placenta is "fresh", i.e. not fixed -- as mass tables are based on fresh state.
*Umbilical cord  
*Umbilical cord  
**Attachment.
**Attachment.
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***Membranous or velamentous (veil-like) insertion.  
***Membranous or velamentous (veil-like) insertion.  
****Vessels separate/branch prior to reaching placental disc.
****Vessels separate/branch prior to reaching placental disc.
***Furcate insertion - vessel run on fetal surface (more exposed to trauma).
***Furcate insertion - blood vessels separate before reaching placenta disc/not surrounded by Wharton's jelly - vessels more exposed to trauma (risk for vasa previa).
**Knots (false vs. true).
**Knots (false vs. true).
***False knots are nothing to worry about -- look like a knot but aren't really one.
***False knots are nothing to worry about -- look like a knot but aren't really one.
**Twisting/coiling.
**Twisting/coiling - 1-3 coils/10 cm is normal.
**Number of vessels.
**Number of vessels.
***Normal: 2 arteries, 1 vein.
***Normal: 2 arteries, 1 vein.
*Membranes - shiny, thin, translucent
*Membranes - shiny & translucent - normal (green, opaque/dull - chorioamnionitis).
**Attachment: marginal (normal), circummarginate (inside edge), circumvallated (folding on self).
**Attachment (insertion): marginal (normal), circummarginate (inside edge), [[circumvallate placenta|circumvallate]] (folding on self).
**Site of rupture - if obvious; low point of rupture suggests low-lying placenta.
*Placental disc.
*Placental disc.
**Fetal surface - normal is shinny (dull in chorioamnionitis).
**Fetal surface - normal is shinny.
**Maternal surface - are the cotyledons intact?
***Dull in chorioamnionitis.
**Maternal surface  
***Are the cotyledons intact?
***Adherent clot?
**Parenchyma - after sectioning:
***White vs. red nodules.
 
Notes:
*Parenchymal nodules - a brief DDx:
**White: [[placental infarct|infarct]] (chronic), thrombi, [[chorangioma]], [[perivillous fibrin deposition]].
**Red: infarct (acute), thrombi.


===Sections===
==Sections==
*Cord two sections.
#Cord two sections.
*Cord at insertion.
#Membranes (rolled), two rolls or more.<ref name=pmid19061291>{{cite journal |author=Winters R, Waters BL |title=What is adequate sampling of extraplacental membranes?: a randomized, prospective analysis |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=12 |pages=1920–3 |year=2008 |month=December |pmid=19061291 |doi= |url=}}</ref>
*Membranes (rolled).
#Cord at insertion + disc.
*Placenta - full thickness (maternal and fetal surface).
#Placenta - full thickness (maternal and fetal surface).
#*Sections should not be taken at the margin of the disc.


===Placental membranes===
==Placental membranes==
Appearance:<ref>Lester 2nd Ed. P.461</ref>
Appearance:<ref name=Ref_Lester461>{{Ref Lester|461}}</ref>
*Normal - shiny.
*Normal - shiny.
*Choriomnionitis - opaque/dull.
*[[Chorioamnionitis]] - opaque/dull.
*Meconium - green.
*Meconium - green.
*Amnion nodosum.
*[[Amnion nodosum]] - yellow patches.
**AKA ''squamous metaplasia of amnion''.<ref>[http://medical-dictionary.thefreedictionary.com/amnion+nodosum]</ref>
**Some describe 'em as white.<ref>CS. 7 February 2011.</ref>
**Assoc. with oligohydramnios.<ref>[http://library.med.utah.edu/WebPath/PLACHTML/PLAC042.html http://library.med.utah.edu/WebPath/PLACHTML/PLAC042.html]</ref>
 
**Gross: - (single) yellow patch or yellow nodules .
==Placental mass==
It is considered routine to obtain a mass for the placenta.  This is usually done when the placenta is fresh and with the membranes and cord trimmed, as most tables of placental mass were created with these parameters. 
 
Placental mass by gestational age:<ref>AFIP Placental pathol. ISBN: 1-881041-89-1. P.312</ref>
{| class="wikitable"
|Gest. Age/Percentile ||'''25%''' ||'''50%''' ||'''75%'''
|-
|'''32 weeks''' ||275 g ||318 g ||377 g
|-
|'''36 weeks''' ||369 g ||440 g ||508 g
|-
|'''40 weeks''' ||440 g ||501 g ||572 g
|-
|}
 
===Linear regression - placental mass-gestational age===
Based on the table in the AFIP book<ref>AFIP Placental pathol. ISBN: 1-881041-89-1. P.312</ref> one can generate the following regression lines:
{| class="wikitable"
| ||'''50%''' ||'''10%''' ||'''90%'''
|-
|slope (g/week) ||21.58088235 ||19.70588235 ||25.40196078
|-
|y-intercept (g) ||-357.4558824 ||-397.2352941 ||-366.7254902
|-
|Pearson (r) ||0.988670724 ||0.988268672 ||0.982206408
|-
|}
 
placental mass = slope x gestational age + intercept
 
===What to remember...===
Extrapolated from the linear regression (see above):
*50% at term = 500 grams.
*50% at 26 weeks = 200 grams.
*The change in mass/week is approximately linear and equal to 300 grams / 14 weeks ~ 20 grams/week.
*The spread in mass between 10% and 90%, crudely estimated, is 200 grams (for GA=26-40).
 
Notes:
*Is it required?
**Sebire and Fox have advocated abandoning the practise of obtaining a placental mass, due to the large number of uncontrolled variables inherent in these measures.  Instead, they have advocated using mushy descriptors such as "small", "average" and "large", which require experience in examining the organ.<ref>{{cite book |author= Fox, Harold; Sebire, Neil J. |title=[http://www.amazon.com/Pathology-Placenta-Major-Problems/dp/1416025928/ref=sr_1_fkmr0_1?ie=UTF8&qid=1297259619&sr=1-1-fkmr0 Pathology of the Placenta (Major Problems in Pathology)]|publisher=Saunders |location= |year=2007 |pages= 559-561 |edition=3rd |isbn=978-1416025924 |oclc= |doi= |accessdate=}}</ref>
***In the context of quality, a measure (even if somewhat flawed) is probably more reproducible and objective than arbitrary descriptors which require experience and a continuing case volume to calibrate.
 
===Placentomegaly===
*[[AKA]] ''large placenta''.
Associations:<ref>URL: [http://quizlet.com/5793113/ob-flash-cards/ http://quizlet.com/5793113/ob-flash-cards/]. Accessed on: 13 January 2012.</ref>
*Maternal [[diabetes]] - esp. poorly controlled.<ref name=pmid2771897>{{Cite journal  | last1 = Clarson | first1 = C. | last2 = Tevaarwerk | first2 = GJ. | last3 = Harding | first3 = PG. | last4 = Chance | first4 = GW. | last5 = Haust | first5 = MD. | title = Placental weight in diabetic pregnancies. | journal = Placenta | volume = 10 | issue = 3 | pages = 275-81 | month =  | year =  | doi =  | PMID = 2771897 }}</ref>
*Maternal [[anemia]]/low maternal iron stores.<ref>{{Cite journal  | last1 = Hindmarsh | first1 = PC. | last2 = Geary | first2 = MP. | last3 = Rodeck | first3 = CH. | last4 = Jackson | first4 = MR. | last5 = Kingdom | first5 = JC. | title = Effect of early maternal iron stores on placental weight and structure. | journal = Lancet | volume = 356 | issue = 9231 | pages = 719-23 | month = Aug | year = 2000 | doi =  | PMID = 11085691 }}</ref>
*Fetal malformations.
*Neoplasms of the placenta, e.g. [[chorangioma]].
*Twin-twin transfusion syndrome.
*Chronic intrauterine infections, e.g. [[syphilis]], [[toxoplasmosis]], [[cytomegalovirus]].
 
Lame causes of a heavy placenta:
*Dates wrong - error in determining the estimated date of confinement.
*Adherent blood clot.
 
Comment:
*Most of causes seem to have one thing in common:
**There is a decreased oxygen delivery to the fetus.
 
====Sign out====
<pre>
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CESAERIAN SECTION:
- LARGE PLACENTA (819 GRAMS -- TRIMMED, POST-FIXATION WEIGHT).
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.
</pre>
 
===Placental growth restriction===
*[[AKA]] ''placenta small for gestational age''.
*''Small placenta'' redirects here.
Associations:
*Maternal vascular disease, e.g. [[hypertrophic decidual vasculopathy|hypertension]].
*Fetal malformations.
 
====Sign out====
<pre>
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- PLACENTA SMALL FOR GESTATIONAL AGE (160 GRAMS -- TRIMMED, POST-FIXATION WEIGHT).
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITH:
-- OLD CENTRAL TRANSMURAL INFARCT (1.7 CM MAXIMAL DIMENSION).
 
COMMENT:
The 10th percentile placental mass (pre-fixation) for 34 weeks and 2 days is approximately 390 grams.
</pre>
 
=Overview of placental pathology=
==Approach==
The pathology of the placenta is diverse and is not easy to group.


==Sign-out==
It terms of remembering things.  It is probably easiest to take a combined anatomical, etiologic and morphologic approach.
 
Anatomical basis:
*Cord.
*Membranes.
*Disc.
 
Etiologic:
*Congential.
*Infectious.
*Neoplastic.
*Endocrine.
*Trauma.
*Vascular.
*Degenerative.
*Autoimmune.
*Toxic.
*Idiopathic.
 
Compartmental:
*Vasculature.
*Membranes.
*Parenchyma:
**Maternal part (decidua).
**Fetal part (villi, cord).
 
==Common entities/diagnoses==
*Normal.
*[[Chorioamnionitis]].
*[[Placental abruption]].
*[[Meconium]].
*Hypertensive changes.
 
=Sign out=
What should be commented on...
What should be commented on...


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***Fetal.
***Fetal.
*Membranes.
*Membranes.
**Membranitis?
**[[Membranitis]]?
**Chorioamnionitis?
**[[Chorioamnionitis]]?
*Cord:
*Cord:
**3 vessel?
**3 vessel?
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Mnemonic: ''chorio, cord, vessels, villi (maturity, infarction)''.
Mnemonic: ''chorio, cord, vessels, villi (maturity, infarction)''.


==Twin placentas==
==Normal placenta==
No membrane between fetuses.
<pre>
*Split at approx. 7th day.
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.
</pre>
 
===C-section===
<pre>
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CAESAREAN SECTION:
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.
</pre>
 
=Cord pathology=
*[[Two vessel cord]].
*Hypercoiling/Hypocoiling.
*Abnormal insertion.
*[[Cord knot]]s (true vs. false).
*Strictures.
*Hematoma.
*[[Hemangioma]].
*Benign cyst.
 
==Two vessel umbilical cord==
*[[AKA]] ''two vessel cord''.
*[[AKA]] ''single umbilical artery''.
{{Main|Two vessel umbilical cord}}
 
==Insertion==
===Marginal insertion===
Definition:
*The umbilical cord is attached to the placental disc at its margin.
 
Prevalence:
*Approximately 12% of placentas.<ref name=Ref_WMSP464>{{Ref WMSP|464}}</ref>
 
Relevance:
*None according to WMSP.<ref name=Ref_WMSP464>{{Ref WMSP|464}}</ref>
**In theory, the cord, dependent on its relation to the internal os, is at greater risk of injury (leading to vasa previa) and compression (fetal hypoxia).  A retrospective study found cord position in relation to the internal os is predictive for vasa previa.<ref name=pmid20872421>{{cite journal |author=Hasegawa J, Farina A, Nakamura M, ''et al.'' |title=Analysis of the ultrasonographic findings predictive of vasa previa |journal=Prenat. Diagn. |volume=30 |issue=12-13 |pages=1121–5 |year=2010 |month=December |pmid=20872421 |doi=10.1002/pd.2618 |url=}}</ref>
 
===Velamentous insertion===
Definition:
*The umbilical cord inserts into the fetal membranes.<ref name=Ref_WMSP464>{{Ref WMSP|464}}</ref>
**The vessels are ''not'' protected by Wharton's jelly.
***Wharton's jelly = the connective tissue surrounding the vessels in the cord.
 
Details:<ref name=Ref_WMSP464>{{Ref WMSP|464}}</ref>
*3/4 of the time the vessel also branch; in the remaining 1/4 the vessels stay together.
 
Relevance:
*Increased risk of vasa previa.<ref name=pmid20872421>{{cite journal |author=Hasegawa J, Farina A, Nakamura M, ''et al.'' |title=Analysis of the ultrasonographic findings predictive of vasa previa |journal=Prenat. Diagn. |volume=30 |issue=12-13 |pages=1121–5 |year=2010 |month=December |pmid=20872421 |doi=10.1002/pd.2618 |url=}}</ref>
 
====Sign out====
<pre>
PLACENTA, UMBILICAL CORDS AND FETAL MEMBRANES, BIRTH:
- THREE VESSEL UMBILICAL CORD WITH A VELAMENTOUS INSERTION, OTHERWISE WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.
</pre>
 
==Umbilical knot==
*[[AKA]] ''umbilical cord knot''.
*[[AKA]] ''cord knot''.
*[[AKA]] ''true knot''.
===General===
*Prevalence ~1.25%.<ref name=pmid12012287>{{cite journal |author=Airas U, Heinonen S |title=Clinical significance of true umbilical knots: a population-based analysis |journal=Am J Perinatol |volume=19 |issue=3 |pages=127–32 |year=2002 |month=April |pmid=12012287 |doi=10.1055/s-2002-25311 |url=}}</ref><ref name=Ref_WMSP>{{Ref WMSP|464}}</ref>
*Increase risk of [[stillbirth]]; odds ratio 3.93.<ref name=pmid12012287/>
 
===Gross===
Work-up:<ref name=Ref_WMSP>{{Ref WMSP|464}}</ref>
*Diameter measures and colour on both sides of the knot.
*Knot should be untied to assess for deformation of Wharton's jelly.
*Sections from both sides of the knot - to look for thrombi.
 
Note:
*False knots (large diameter - focally) are common - they cannot be untied.
 
===Microscopic===
Features:
*+/-[[thrombosis|Thrombi]].
**Fibrin deposition.
*+/-Lines of Zahn.
 
Images:
*[http://library.med.utah.edu/WebPath/ATHHTML/ATH031.html Lines of Zahn (utah.edu)].
*[http://pathhsw5m54.ucsf.edu/case9/image94.html Lines of Zahn (ucsf.edu)].
 
==Coiling==
*Hypo- and hypercoiling are both considered problematic.<ref name=Ref_WMSP464>{{Ref WMSP|464}}</ref>
**Normal: 1-3 coils/10 cm.<ref>CS. 7 February 2011.</ref>
*Associated with cord stricture, which is usu. at the fetal end of the cord.<ref name=Ref_WMSP465>{{Ref WMSP|465}}</ref>
 
Notes:
*There is little uniformity in how coiling is assessed in the medical literature - though 10% and 90% are considered the cut-points for normal.<ref name=pmid21080869>{{cite journal |author=Khong TY |title=Evidence-based pathology: umbilical cord coiling |journal=Pathology |volume=42 |issue=7 |pages=618–22 |year=2010 |month=December |pmid=21080869 |doi=10.3109/00313025.2010.520309 |url=}}</ref>
**What are the 10% and 90% cut-points? They are not given in WMSP. UT access to a journal article<ref name=pmid16076615>PMID 16076615.</ref> that might have it is screwed-up.
 
==Cord hematoma==
Features:<ref name=Ref_WMSP465>{{Ref WMSP|465}}</ref>
*Rare ~ 1/5500.
*Mortality ~50% is severe.


===Diamnionic-monochorionic (DiMo)===
=Membranes=
*No interposed chorion.<ref>Histo. for Pathol. 2nd Ed. P.979</ref>
*Squamous metaplasia.
*Always monozygotic.
*[[Chorioamnionitis]] - see ''infection'' section.
*Highest risk of TTTS (twin-to-twin transfusion syndrome).


===Diamnionic-dichorionic (DiDi)===
==Amnion nodosum==
*Most dizygotic (70%), may be monozygotic (30%).
{{Main|Amnion nodosum}}
*If monozygotic -- split before 3 days.


==Bleeding in late pregnancy==
==Placental meconium==
DDx of bleeding in late pregnancy:
{{Main|Placental meconium}}
*Placental abruption (most common).
 
*Placenta previa.
==Squamous metaplasia of the amnion==
*Vasa previa (fetus losing blood).
===General===
*Benign common finding thought to be of no clinical significance.<ref name=Ref_WMSP463>{{Ref WMSP|463}}</ref>
**One case report suggesting an association with [[chorioamnionitis]].<ref>{{Cite journal  | last1 = Chew | first1 = RH. | last2 = Silberberg | first2 = BK. | title = Possible association of acute inflammatory exudate in chorioamnionitis and amniotic squamous metaplasia. | journal = Am J Clin Pathol | volume = 93 | issue = 4 | pages = 582-5 | month = Apr | year = 1990 | doi =  | PMID = 2321592 }}</ref>
*Needs to be separated from amnion nodosum - '''important'''.<ref>CS. 7 February 2011.</ref>
 
===Gross===
Features:<ref name=pmid18081444>{{Cite journal  | last1 = Adeniran | first1 = AJ. | last2 = Stanek | first2 = J. | title = Amnion nodosum revisited: clinicopathologic and placental correlations. | journal = Arch Pathol Lab Med | volume = 131 | issue = 12 | pages = 1829-33 | month = Dec | year = 2007 | doi = 10.1043/1543-2165(2007)131[1829:ANRCAP]2.0.CO;2 | PMID = 18081444 }}</ref>
*White (or yellow) plaques - irregular outline.
 
DDx:
*[[Amnion nodosum]] - small (~1-5 mm), round, classically yellow.
 
Images:
*[http://www.archivesofpathology.org/action/showFullPopup?id=i1543-2165-131-12-1829-f01&doi=10.1043%2F1543-2165%282007%29131%5B1829%3AANRCAP%5D2.0.CO%3B2 Amnion nodosum & squamous metaplasia of the amnion (archivesofpathology.org)].<ref name=pmid18081444/>
<!-- annoying use of '[' and ']' - had to go find escape characters here: http://www.w3schools.com/tags/ref_urlencode.asp -->
 
===Microscopic===
Features:<ref name=pmid18081444/>
*Dense, paucicellular (pink) compact keratin - '''key feature'''.
 
Image:
*[http://flylib.com/books/2/953/1/html/2/43%20-%20Placenta_files/DA10C43FF29.png Squmous metaplasia of the amnion (flylib.com)].<ref>URL: [http://flylib.com/books/en/2.953.1.49/1/ http://flylib.com/books/en/2.953.1.49/1/]. Accessed on: 10 January 2011.</ref>
 
==Circumvallate placenta==
*[[AKA]] ''circumvallate insertion of the membranes''.
===General===
*May be associated with [[placental abruption]].<ref name=pmid18226129>{{Cite journal  | last1 = Suzuki | first1 = S. | title = Clinical significance of pregnancies with circumvallate placenta. | journal = J Obstet Gynaecol Res | volume = 34 | issue = 1 | pages = 51-4 | month = Feb | year = 2008 | doi = 10.1111/j.1447-0756.2007.00682.x | PMID = 18226129 }}</ref>
 
Note:
*Membranes usually attach to the edge of the placenta.
 
===Gross===
*Fetal membranes attach to the fetal surface of the placenta away from the margin of the placental disc.
 
Classification:
*Partial - not circumferential.
*Complete.
 
DDx:
*[[Circummarginate placenta]].
 
Images:
*[http://library.med.utah.edu/nmw/mod2/Tutorial2/pics/circumvallate.jpg Circumvallate placenta - partial and complete (utah.edu)].
*[http://library.med.utah.edu/WebPath/jpeg2/PLAC027.jpg Circumvallate placenta (utah.edu)].
 
=Twin placentas=
{{Main|Twin placentas}}
These are often submitted... even if they are normal.  In these specimens, usually, the chorion is the key.
 
It covers:
*Monozygotic vs. dizygotic twins.
*Twin-to-twin transfusion syndrome.
 
=Placental disc=
==Villous edema==
===General===
*Non-specific finding.
*Reported in associated with congenital adrenal hyperplasia for the stem villi.<ref name=pmid11045335>{{Cite journal  | last1 = Furuhashi | first1 = M. | last2 = Oda | first2 = H. | last3 = Nakashima | first3 = T. | title = Hydrops of placental stem villi complicated with fetal congenital adrenal hyperplasia. | journal = Arch Gynecol Obstet | volume = 264 | issue = 2 | pages = 101-4 | month = Sep | year = 2000 | doi =  | PMID = 11045335 }}</ref>
 
===Microscopic===
Features:
*"Swiss chesse-like" appearance / bubbly appearance.
*Usually patchy and focal.
 
Note:
*Cistern formation is reported in the stem villi in association with congenital adrenal hyperplasia.<ref name=pmid11045335/>
 
DDx:  
*[[Chorioamnionitis]].
*Fetal edema.
*Idiopathic (no cause apparent).
*[[Placental villous immaturity]].
 
Image:
*[http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Image19.gif villous edema (yale.edu)].<ref>URL: [http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html]. Accessed on: 28 May 2011.</ref>
 
==Placental villous immaturity==
{{Main|Placental villous immaturity}}
 
==Villous hypoplasia==
*[[AKA]] ''terminal villus deficiency''.<ref name=Ref_Placenta346>{{Ref Placenta|346}}</ref>
{{Main|Villous hypoplasia}}
 
=Diseases of the placental attachment=
==Placenta creta==
Includes ''placenta accreta'', ''placenta increta'', and ''placenta percreta''.
{{Main|Placenta creta}}


==Placental abruption==
==Placental abruption==
*Central haemorrhage is the most worrisome.
{{Main|Placental abruption}}
**Pathologic findings (gross): depression on maternal side, large blood clot.
***There are *no* good microscopic findings.
 
==Infection==
Types (by site):<ref name=Ref_PBoD1106>{{Ref PBoD|1106}}</ref>
*Fetal membranes: chorioamnionitis, membranitis.<ref>Sternberg P.2311</ref>
*Umbilical cord: funisitis.
*Placenta: placentitis, villitis.


=Inflammatory pathologies=
===Overview of infections===
General:<ref name=Ref_PBoD1106>{{Ref PBoD|1106}}</ref>
General:<ref name=Ref_PBoD1106>{{Ref PBoD|1106}}</ref>
*Infection usually ascending, i.e. from vagina up through cervix.
*Infection usually ascending, i.e. from vagina up through cervix.
**Assoc. with intercourse.
**Associated with intercourse.
*Hematogenous rare - manifest as villitis.
*Hematogenous rare - manifest as villitis.
**Think ''[[TORCH infections]]'' (toxoplasmosis, others (syphilis, TB, listeriosis), rubella, cytomegalovirus, herpes simplex virus).
**Think ''[[TORCH infections]]'' ([[toxoplasmosis]], others ([[syphilis]], [[TB]], listeriosis), rubella, [[cytomegalovirus]], [[herpes simplex virus]]).
*Funisitis usually follows chorioamnionitis.
*Funisitis usually follows chorioamnionitis.
**Inflammatory cells in umbilical cord are fetal (trivia).
**Inflammatory cells in umbilical cord are fetal (trivia).


===Grading infection===
====Types====
Membranitis<ref>Sternberg P.2311</ref>
By site:<ref name=Ref_PBoD1106>{{Ref PBoD|1106}}</ref>
*Fetal membranes: chorioamnionitis, membranitis.<ref name=Ref_Sternberg4_2311>{{Ref Sternberg4|2311}}</ref>
*Umbilical cord: funisitis.
*Placenta: placentitis, villitis.
 
==Membranitis==
:''Chorionitis'' redirects here.
===General===
*Early [[chorioamnionitis]].<ref>{{Cite journal  | last1 = Vedovato | first1 = S. | last2 = Zanardo | first2 = V. | title = [Chorioamnionitis and inflammatory disease in the premature newborn infant]. | journal = Minerva Pediatr | volume = 62 | issue = 3 Suppl 1 | pages = 155-6 | month = Jun | year = 2010 | doi =  | PMID = 21090086 }}</ref>
*Controversial.{{fact}}
 
===Microscopic===
Features:
*[[PMN]]s in the decidua.
*+/-PMNs in subamniotic tissue.
*+/-Necrosis in decidua or chorion/subamniotic tissue.
 
Note:
*Plasma cells in the decidua = [[chronic deciduitis]].
 
DDx:
*[[Chorioamnionitis]].
 
====Grading membranitis====
''Sternberg'':<ref name=Ref_Sternberg4_2311>{{Ref Sternberg4|2311}}</ref>
# PMNs - decidua only.
# PMNs - decidua only.
# PMNs - in subamniotic tissue.
# PMNs - in subamniotic tissue.
# 1 or 2 + necrosis in decidua or chorion/subamniotic tissue.
# 1 or 2 + [[necrosis]] in decidua or chorion/subamniotic tissue.
 
Chorioamnionitis<ref>Sternberg P.2311</ref>
# placental chorionic plate only.
# 1 + subamniotic tissue.
# 1 or 2 + necrosis or abscess.
 
Sternberg separates ''vasculitis'' and ''funisitis'' without really explaining the terms<ref>Sternberg P.2311.</ref> -- I presume:
''vasculitis'' = inflammation of vessels in the umbilical cord.
''funisitis'' = inflammation of the cord (vessels and Wharton jelly).


Umbilical cord vasculitis:<ref>Sternberg P.2311</ref>
===Sign out===
* +0.5 for each vessel.
<pre>
* +0.5 for each vessel with severe involvement.
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CESAERIAN SECTION:
- FETAL MEMBRANES WITH CHORIONITIS.
- THREE VESSEL UMBILICAL CORD WITH VASCULITIS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.
</pre>


Umbilical funisitis:<ref>Sternberg P.2311</ref>
====Waffle====
# focal inflammation.
<pre>
# diffuse inflammation.
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
# necrosis - in vessels or Wharton jelly.
- FETAL MEMBRANES WITH MECONIUM-LADEN MACROPHAGES AND ABUNDANT DECIDUAL NEUTROPHILS
  SUSPICIOUS FOR EARLY CHORIONITIS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
</pre>


Note: There is no such thing as ''chorionitis''.<ref>ALS Feb 2009</ref>
==Chorioamnionitis==
===IHC===
{{Main|Chorioamnionitis}}
Useful to differentiate hemosiderin-laden macrophages and meconium laden macrophages:
*Hemosiderin stain -- +ve for old blood.
**Prussian-blue stain = hemosiderin stain.<ref>{{cite journal |author=Sienko A, Altshuler G |title=Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines |journal=Obstet Gynecol |volume=94 |issue=3 |pages=415?0 |year=1999 |month=September |pmid=10472870 |doi= |url=}}</ref>
*PAS-D -- +ve in chorioamnionitis???


Note:
==Umbilical cord vasculitis==
*Meconium contains bile.<ref>{{cite journal |author=Sienko A, Altshuler G |title=Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines |journal=Obstet Gynecol |volume=94 |issue=3 |pages=415?0 |year=1999 |month=September |pmid=10472870 |doi= |url=}}</ref>
{{Main|Umbilical cord vasculitis}}


==Infarction==
==Funisitis==
===General===
{{Main|Funisitis}}
*Associated with retroplacental hematoma.
*Inflammation of Wharton's jelly - the connective tissue of the umbilical cord.


===Gross===
==Acute villitis==
Features:<ref name=Ref_WMSP465>{{Ref WMSP|465}}</ref>
{{main|Acute villitis}}
*Early - red.
*Late - white/grey.


===Microscopy===
==Villitis of unknown etiology==
Features:
{{Main|Villitis of unknown etiology}}
*Loss of intervillous space.<ref name=Ref_WMSP465>{{Ref WMSP|465}}</ref>
**Villi appear to be crowded.
<ref>{{Ref PBoD|1109}}</ref>
*Prominent syncytial knots.
*Thickened trophoblastic basement membrance (below [[cytotrophoblast]]s).
*+/-Acute atherosis (vaguely like atherosclerosis).
**Fibrioid necrosis.
**Vessel wall lipid deposition.


===Significant infarcts===
==Chronic intervillitis==
*> 3cm --or-- central location --or-- in 1st or 2nd trimester.
*[[AKA]] ''chronic intervillositis''.<ref name=pmid8215826>{{Cite journal  | last1 = Jacques | first1 = SM. | last2 = Qureshi | first2 = F. | title = Chronic intervillositis of the placenta. | journal = Arch Pathol Lab Med | volume = 117 | issue = 10 | pages = 1032-5 | month = Oct | year = 1993 | doi =  | PMID = 8215826 }}</ref>
**Small foci are accepted in term placentae - typically at periphery.


==Chorangioma==
===General===
===General===
*Hemangioma ???
*Rare.
 
*Massive chronic intervillitis - associated [[IUGR]], spontaneous abortion, perinatal fetal death.<ref name=pmid17088773>{{Cite journal  | last1 = Rota | first1 = C. | last2 = Carles | first2 = D. | last3 = Schaeffer | first3 = V. | last4 = Guyon | first4 = F. | last5 = Saura | first5 = R. | last6 = Horovitz | first6 = J. | title = [Perinatal prognosis of pregnancies complicated by placental chronic intervillitis]. | journal = J Gynecol Obstet Biol Reprod (Paris) | volume = 35 | issue = 7 | pages = 711-9 | month = Nov | year = 2006 | doi = | PMID = 17088773 }}</ref>
===Epidemiology===
*Recurs.
*Often benign.
===Microscopic===
*May be assoc. with:
Features:<ref name=pmid8215826/><ref name=pmid17088773/>
**Fetal maternal haemorrhage.
*Intervillous inflammatory cells:
**Hydrops.
**Lymphocytes.
**[[IUGR]].
**Histiocytes.
*Fibrinoid deposition.


===Microscopy===
====Images====
*Mass of capillaries.
<gallery>
Image:Intervillitis_-_intermed_mag.jpg | Intervillitis - intermed. mag. (WC)
Image:Intervillitis_-_very_high_mag.jpg | Intervillitis - very high mag. (WC)
</gallery>
==Chronic deciduitis==
*[[AKA]] plasma cell deciduitis.
{{Main|Chronic deciduitis}}


=Placental infarction=
==True infarcts==
{{Main|Placental infarct}}


==Perivillous fibrin deposition==
==Perivillous fibrin deposition==
*Massive perivillous fibrin deposition is assoc. with anti-phospholipid antibody (APLA) syndrome.<ref name=pmid12066949>{{cite journal |author=Sebire NJ, Backos M, Goldin RD, Regan L |title=Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome |journal=BJOG |volume=109 |issue=5 |pages=570–3 |year=2002 |month=May |pmid=12066949 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1470-0328&date=2002&volume=109&issue=5&spage=570}}</ref>
*Abbreviation ''PFD''.
**APLA is assoc. with recurrent miscarriage - can be treated with heparin + ASA.<ref name=pmid12066949/>
===General===
*Thought to be an immunologic problem - resulting in platelet activation and fibrin deposition.<ref name=pmid12066949/>
*Thought to be an immunologic problem - resulting in platelet activation and fibrin deposition.<ref name=pmid12066949>{{Cite journal | last1 = Sebire | first1 = NJ. | last2 = Backos | first2 = M. | last3 = Goldin | first3 = RD. | last4 = Regan | first4 = L. | title = Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome. | journal = BJOG | volume = 109 | issue = 5 | pages = 570-3 | month = May | year = 2002 | doi = | PMID = 12066949 }}</ref>
*May be associated with [[diabetes mellitus]].<ref name=Ref_Placenta327>{{Ref Placenta|327}}</ref>


===Gross===
===Gross===
Line 207: Line 643:
*White fibrous sepatae.
*White fibrous sepatae.


===Microscopy===
===Microscopic===
Features:
*Acellular eosinophilic material around formed villi.
*Acellular eosinophilic material around formed villi.
**Obliteration of intervillous space.
*Obliteration of intervillous space.
 
**Intervillous distance increased vis-a-vis normal - '''key feature'''.
 
==Passage of meconium==
===General===
*Associated with fetal distress.
 
===Gross===
*Green/green discolourization.


===Microscopy<ref>ALS. 6 Feb 2009.</ref>===
Notes:
*Macrophages with brown fine granular pigment.
*Nuclei of villi are usually preserved.
*Columnar morphology (normally cuboidal).
*Villi may have secondary infarction, i.e. there may be [[Basics#Nuclear destruction words|nuclear destruction]] (karyolysis, karyorrhexis, pyknosis).
*"Drop-out" of individual cell -- the loss of individual cells.


Level of staining and time:<ref>3 Apr 2009.</ref>
DDx:
*<1 h - no staining of membranes.
*[[Placental infarction]] - loss of nuclei in the villi (below the edge of the lesion).
*1-3 h - amnion is stained.
*[[Massive perivillous fibrin deposition]] (maternal floor infarct).
*>3 h - chorion is stained.


Images:
Images:
*[http://commons.wikimedia.org/wiki/File:Meconium-laden_macrophages_high_mag.jpg Meconium-laden macrophages - high mag. (WC)].
*[http://path.upmc.edu/cases/case75.html APLA syndrome (upmc.edu)].
*[http://commons.wikimedia.org/wiki/File:Meconium-laden_macrophages_intermed_mag.jpg Meconium-laden macrophages - intermed. mag. (WC)].


===DDx===
===Sign out===
*Hemosiderin-laden macrophages.
====Thrombi====
<pre>
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI AND THREE LARGE INTERVILLOUS
THROMBI (BLOCKS A7-A9).
</pre>


===Special stains===
==Maternal floor infarction==
*Hemosiderin +ve in hemosiderin-laden macrophages.
*Abbreviated ''MFI''.
*PAS +ve in meconium-laden macrophages.<ref name=pmid11268705>PMID 11268705</ref>
*Formally ''placental maternal floor infarction''.
*[[AKA]] ''massive perivillous fibrin deposition''.<ref name=Ref_Placenta367>{{Ref Placenta|367}}</ref>
{{Main|Maternal floor infarction}}


==Placental mass==
=Fetal disease=
Placental mass by gestational age:<ref>AFIP Placental pathol. ISBN: 1-881041-89-1. P.312</ref>
==Fetal thrombotic vasculopathy==
{| class="wikitable"
*Abbreviated ''FTV''.
|Gest. Age/Percentile ||'''25%''' ||'''50%''' ||'''75%'''
*A large number of terms are used for this including:<ref name=pmid19237859>{{Cite journal  | last1 = Marchetti | first1 = D. | last2 = Belviso | first2 = M. | last3 = Fulcheri | first3 = E. | title = A case of stillbirth: the importance of placental investigation in medico-legal practice. | journal = Am J Forensic Med Pathol | volume = 30 | issue = 1 | pages = 64-8 | month = Mar | year = 2009 | doi = 10.1097/PAF.0b013e318187387e | PMID = 19237859 }}</ref>
|-
**''Fibrinous vasculosis''.
|'''32 weeks''' ||275 g ||318 g ||377 g
**''Fibromuscular sclerosis''.
|-
**''Fetal artery stem thrombosis''.
|'''36 weeks''' ||369 g ||440 g ||508 g
*The multitude of terms reflects the confusion about this finding and that it has numerous etiologies.<ref name=pmid19237859/>
|-
{{Main|Fetal thrombotic vasculopathy}}
|'''40 weeks''' ||440 g ||501 g ||572 g
|-
|}


===Linear regression - placental mass-gestational age===
==Hemorrhagic endovasculitis==
Based on the table in the AFIP book<ref>AFIP Placental pathol. ISBN: 1-881041-89-1. P.312</ref> I generated the following regression lines:
*Abbreviated ''HEV''.
{| class="wikitable"
===General===
| ||'''50%''' ||'''10%''' ||'''90%'''
*Associated with stillbirth.<ref name=pmid6151926>{{cite journal |author=Stevens NG, Sander CH |title=Placental hemorrhagic endovasculitis: risk factors and impact on pregnancy outcome |journal=Int J Gynaecol Obstet |volume=22 |issue=5 |pages=393–7 |year=1984 |month=October |pmid=6151926 |doi= |url=}}</ref>
|-
|slope (g/week) ||21.58088235 ||19.70588235 ||25.40196078
|-
|y-intercept (g) ||-357.4558824 ||-397.2352941 ||-366.7254902
|-
|Pearson (r) ||0.988670724 ||0.988268672 ||0.982206408
|-
|}


placental mass = slope x gestational age + intercept
===Microscopic===
 
Features:<ref name=pmid11825110>{{cite journal |author=Sander CM, Gilliland D, Akers C, McGrath A, Bismar TA, Swart-Hills LA |title=Livebirths with placental hemorrhagic endovasculitis: interlesional relationships and perinatal outcomes |journal=Arch. Pathol. Lab. Med. |volume=126 |issue=2 |pages=157–64 |year=2002 |month=February |pmid=11825110 |doi= |url=}}</ref>
===What to remember...===
*Walls of the (fetal) placental blood vessels (in the villi) are disrupted.
Extrapolated from the linear regression (see above):
*+/-Intraluminal necrotic debris.
*50% at term = 500 grams.
*[[RBC]] fragmentation.
*50% at 26 weeks = 200 grams.
*The change in mass/week is approximately linear and equal to 300 grams / 14 weeks ~ 20 grams/week.
*The spread in mass between 10% and 90%, crudely estimated, is 200 grams (for GA=26-40).


=Maternal disease=
==Hypertensive changes==
==Hypertensive changes==
Features:<ref name=pmid6754249>{{cite journal |author=Soma H, Yoshida K, Mukaida T, Tabuchi Y |title=Morphologic changes in the hypertensive placenta |journal=Contrib Gynecol Obstet |volume=9 |issue= |pages=58–75 |year=1982 |pmid=6754249 |doi= |url=}}</ref>
===General===
*Enlarged endothelial cells - fetal capillaries.
Associated pathologic changes:<ref name=pmid6754249>{{cite journal |author=Soma H, Yoshida K, Mukaida T, Tabuchi Y |title=Morphologic changes in the hypertensive placenta |journal=Contrib Gynecol Obstet |volume=9 |issue= |pages=58–75 |year=1982 |pmid=6754249 |doi= |url=}}</ref>
*Atherosis of the spiral arteries - placental bed (maternal).
 
Associated changes:<ref name=pmid6754249/>
*Placental infarcts.  
*Placental infarcts.  
*Increased syncytial knots.
*Increased syncytial knots.
Line 287: Line 707:
*Thickening of the trophoblastic basement membrane.
*Thickening of the trophoblastic basement membrane.


===Hypertrophic decidual vasculopathy===
===Microscopic===
Features:<ref name=pmid18641412>{{Cite journal | last1 = Roberts | first1 = DJ. | last2 = Post | first2 = MD. | title = The placenta in pre-eclampsia and intrauterine growth restriction. | journal = J Clin Pathol | volume = 61 | issue = 12 | pages = 1254-60 | month = Dec | year = 2008 | doi = 10.1136/jcp.2008.055236 | PMID = 18641412 }}</ref>
Features:<ref name=pmid6754249>{{cite journal |author=Soma H, Yoshida K, Mukaida T, Tabuchi Y |title=Morphologic changes in the hypertensive placenta |journal=Contrib Gynecol Obstet |volume=9 |issue= |pages=58–75 |year=1982 |pmid=6754249 |doi= |url=}}</ref>
*Mild or moderate:
*Enlarged endothelial cells - fetal capillaries.  
*#Perivascular inflammatory cells.
*Atherosis of the spiral arteries - placental bed (maternal).
*#+/-Vascular thrombosis.
*#Smooth muscle hypertrophy.
*#Endothelial hyperplasia.
*#*Above two lead to narrowing of the decidual spiral arteries<ref>AFIP - Placental Pathology. P.122. ISBN: 1-881041-89-1. 2004.</ref> -- '''key feature'''.
*Severe:<ref name=pmid18641412/>
*#Atherosis of maternal blood vessels.
*#*Foamy macrophages within vascular wall.
*#Fibrinoid necrosis of vessel wall (amorphous eosinophilic material vessel wall).


General:
Notes:
*Seen in intrauterine growth restriction (IUGR).
*One should look for the changes in the membrane roll, not the maternal surface.<ref>Sherman, C. 7 February 2011.</ref>


Images:
Images:
*[http://commons.wikimedia.org/wiki/File:Hypertrophic_decidual_vasculopathy_intermed_mag.jpg HDV - intermed. mag. (WC)].
*[http://www.pathxchange.org/case/19711 Pregnancy-induced hypertension (pathxchange.org)].
*[http://commons.wikimedia.org/wiki/File:Hypertrophic_decidual_vasculopathy_low_mag.jpg HDV - low mag. (WC)].
 
==Hypertrophic decidual vasculopathy==
:[[AKA]] ''decidual vasculopathy''.
{{Main|Hypertrophic decidual vasculopathy}}


==HELLP syndrome==
==HELLP syndrome==
{{Main|HELLP syndrome}}
==Malaria==
{{Main|Malaria}}
===General===
===General===
*Diagnosed clinically.
*Uncommon in Canada.
*May lead to fetal demise.
 
===Microscopic===
Feature:
*[[RBC]]s with basophilic dots ~1-2 micrometres.


Definition:
====Image====
*'''H''' = hemolysis.
<gallery>
*'''EL''' = elevated liver enzymes.
Image:Maternal_malaria_placenta_-_very_high_mag.jpg | Maternal malaria - very high mag. (WC)
*'''LP''' = low platelets.
</gallery>
=Tumours=
{{main|Gestational trophoblastic disease}}
 
==Chorangioma==
{{Main|Chorangioma}}
 
==Chorangiomatosis==
===General===
Associated with:
*Preeclampsia.
*[[IUGR]].
 
===Gross===
*Multiple tan nodules.


===Microscopic===
===Microscopic===
Features:<ref name=pmid7966086>{{cite journal |author=Ornstein MH, Rand JH |title=An association between refractory HELLP syndrome and antiphospholipid antibodies during pregnancy; a report of 2 cases |journal=J. Rheumatol. |volume=21 |issue=7 |pages=1360–4 |year=1994 |month=July |pmid=7966086 |doi= |url=}}</ref>
Features:
*Thrombotic microangiopathic vasculopathy.
*Multiple chorangiomas - the difference between chorangioma and chorangiomatosis is not well defined.<ref>URL: [http://path.upmc.edu/cases/case655/dx.html http://path.upmc.edu/cases/case655/dx.html]. Accessed on: 28 January 2012.</ref>
**In essence: severe ''hypertrophic decidual vasculopathy''. (???)
 
Images:
*[http://path.upmc.edu/cases/case655.html Chorangiomatosis - several images (upmc.edu)].
 
==Chorangiosis==
{{Main|Chorangiosis}}
 
=Other=
==Fetus papyraceus==
*May be spelled ''foetus papyraceus''.
*[[AKA]] ''fetus compressus''.
{{Main|Fetus papyraceus}}
 
==Placental mesenchymal dysplasia==
*Abbreviated ''PMD''.
{{Main|Placental mesenchymal dysplasia}}


==Tumours==
=Placental cysts and pseudocysts=
{{main|Gestational trophoblastic disease}}
Types:<ref name=Ref_Placenta219-220>{{Ref Placenta|219-220}}</ref>
*Amnionic epithelial inclusion cyst (amniotic cyst).
*[[Epidermal inclusion cyst]] - lined by keratinized squamous epithelium.
*Chorionic cyst ([[AKA]] chorionic pseudocyts).
*Cell island cyst.
 
Other considerations:<ref name=pmid12054300>{{Cite journal  | last1 = Brown | first1 = DL. | last2 = DiSalvo | first2 = DN. | last3 = Frates | first3 = MC. | last4 = Davidson | first4 = KM. | last5 = Genest | first5 = DR. | title = Placental surface cysts detected on sonography: histologic and clinical correlation. | journal = J Ultrasound Med | volume = 21 | issue = 6 | pages = 641-6; quiz 647-8 | month = Jun | year = 2002 | doi =  | PMID = 12054300 }}</ref>
*Hematoma.
*Fibrin-lined pseudocyst.


==Clinical screening tests==
General:<ref name=pmid12054300/>
*PAPP-A - low values seen in aneuploidy.<ref>URL: [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069]. Accessed on: 7 July 2010.</ref>
*Usually good outcome.
*Large cysts (>4.5 cm) or multiple cysts (>3) are associated with [[IUGR]].


{{main|Pregnancy}}
Images:
*[http://www.jultrasoundmed.org/content/21/6/641/F5.expansion.html Subchorionic cysts (jultrasoundmed.org)].<ref name=pmid12054300/>


==See also==
=See also=
*[[Chorionic villi]].
*[[Chorionic villi]].
*[[Endometrium]].
*[[Endometrium]].
*[[Pregnancy]].
*[[Pregnancy]].
*[[Gestational trophoblastic disease]].
*[[TORCH infections]].


==References==
=References=
{{reflist|2}}
{{reflist|2}}


[[Category:Gynecology]]
=Recommended reading=
*{{cite journal |author=Langston C, Kaplan C, Macpherson T, ''et al.'' |title=Practice guideline for examination of the placenta: developed by the Placental Pathology Practice Guideline Development Task Force of the College of American Pathologists |journal=Arch. Pathol. Lab. Med. |volume=121 |issue=5 |pages=449–76 |year=1997 |month=May |pmid=9167599 |doi= |url=}}
*{{cite book |author= Baergen, Rebecca N. |title=[http://www.amazon.com/Manual-Benirschke-Kaufmanns-Pathology-Placenta/dp/0387220895/ref=sr_1_1?ie=UTF8&qid=1297169019&sr=8-1 Manual of Benirschke and Kaufmann's Pathology of the Human Placenta]  |publisher=Springer |location= |year=2005 |pages= {{{1|}}} |edition=1st |isbn=978-0387220895 |oclc= |doi= |accessdate=}}
 
=External links=
*[http://emedicine.medscape.com/article/262470-overview Cord complications (emedicine.medscape.com)].
*[http://www.palpath.com/MedicalTestPages/placenta2.htm Placenta notes (palpath.com)].
 
[[Category:Placenta]]

Latest revision as of 15:27, 10 May 2018

A placenta (fetal aspect) with attached umbilical cord. (WC/Asturnut)

The placenta feeds the developing baby, breathes for it and disposes of its waste.

The organ is one that seems to be left behind; at least one review suggests it isn't done so well by general pathologists.[1]

Placental pathology redirects to this article.

Clinical

Examination of the placenta

  • Most placentas are not examined by a pathologist.

Indications for exam by pathology

Some indications for exam by a pathologist:

  • Abnormalities in the:
    1. Fetus:
      • Bad fetal outcome.
      • Suspected or known congenital abnormalities or chromosomal abnormalities.
      • IUGR.
    2. Mother:
      • Infection/suspected infection.
      • Pre-term labour.
      • Maternal disease (e.g. SLE, coagulopathy).
      • Complicated pregnancy (preclampsia, pregnancy induced hypertension, gestational diabetes).
    3. Placenta:
      • Unusual gross characteristics.[2]

A more detailed list is given by Hargitai et al.[3] and Chang.[4]

Most common

Most common reasons for submitting a placenta to pathology:[5]

  1. Prematurity.
  2. PROM / possible chorioamnionitis.
  3. Multiple gestation.

Bleeding in late pregnancy

DDx of bleeding in late pregnancy:

Clinical screening tests

Main article: Pregnancy
  • PAPP-A - low values seen in aneuploidy.[6]

Abbreviations

  • C/S = Caesarean section.
  • LSCS = lower segment C-section.
  • FTP = failure to progress.
  • PROM = premature rupture of membranes.
  • PPROM = preterm premature ruptures of membranes.
  • IUGR = intrauterine growth restriction.
  • IOL = induction of labour.

Normal histology

Villi

Main article: Chorionic villi

This is dealt with in a separate article that also covers the types of trophoblast (cytotrophoblast, syncytiotrophoblast, intermediate trophoblast).

Cord

Omphalomesenteric duct remnant

  • AKA vitelline duct.
  • Benign embryologic remnant.

Features:

  • Duct with benign looking cuboidal epithelium.

Allantoic duct remnant

  • Benign embryologic remnant.

Features:

  • Duct with benign looking flat epithelium.

Vitelline artery remnant

Features:

  • Small artery in the cord.

Membranes

Fetus to mother:

  • Amnion - thin layer: one cell layer, basement membrane, connective tissue.
  • Cleft - artifactual - empty space.
  • Chorion - vascular.
  • Decidua (maternal tissue) - may contain obsolete chorionic villi; place to look for hypertensive changes.

Amnion

General:

  • Next to fetus, surrounds amniotic fluid, avascular.

Characteristics:

  • Characterized by a single layer of cells.[7]
    • Cuboidal/squamoid shape.
    • Eosinophilic cytoplasm.
    • Central nucleus.
  • Squamous metaplasia may be seen at cord insertion.
  • Basement membrane.
  • 'Compact layer'.[7]
  • 'Fibroblastic layer'.[7]

Chorion

General:

  • Surrounds amnion.

Characteristics:

  • Layers:[8]
    • 'Reticular layer' - cellular (inner aspect).
    • 'Pseudo-basemement membrane'.
    • 'Outer trophoblastic layer'.
  • Has blood vessels.
  • Opposed to "trophoblastic X cells" on side opposite of amnion.[7]
    • Beneath of the "trophoblastic X cells" is decidua (mnemonic NEW = nucleus central, eosinophilic, well-defined cell border), which is maternal tissue.

Note:

  • Fibrin deposition may be found deep to the chorion - known as subchorionic fibrin deposition.
    • Gross: subchorionic, white/yellow, laminated, classically has a triangular-shape with the base of triangle parallel to fetal aspect of disc.
      • Arises due to localized stasis of the inter-villous maternal blood.
    • Focal small deposits are considered to be a normal finding - seen in ~15% of cases.[9][10]

Image:

Common terms

  • Chorionic plate - fetal aspect of placenta.
  • Basal plate - maternal aspect of placenta.
    • Has extravillous trophoblast.
    • Place to look for maternal vessels.

Grossing

This is often very quick. The gross is quite important, as some things cannot be diagnosed microscopically.

General

  • Dimensions:
    • Disc.
    • Length of cord, diameter of cord.
    • Accessory lobes - dimensions.
      • Two lobes of equal size + cord arises in between = bilobate placenta.
  • Mass (weight).
    • Should be done 'trimmed' (cord cut-off, membrane cut-off).
    • Should be done when placenta is "fresh", i.e. not fixed -- as mass tables are based on fresh state.
  • Umbilical cord
    • Attachment.
      • Location: central, eccentric, marginal.
        • Marginal attachment assoc. with hypertension[11]
      • Membranous or velamentous (veil-like) insertion.
        • Vessels separate/branch prior to reaching placental disc.
      • Furcate insertion - blood vessels separate before reaching placenta disc/not surrounded by Wharton's jelly - vessels more exposed to trauma (risk for vasa previa).
    • Knots (false vs. true).
      • False knots are nothing to worry about -- look like a knot but aren't really one.
    • Twisting/coiling - 1-3 coils/10 cm is normal.
    • Number of vessels.
      • Normal: 2 arteries, 1 vein.
  • Membranes - shiny & translucent - normal (green, opaque/dull - chorioamnionitis).
    • Attachment (insertion): marginal (normal), circummarginate (inside edge), circumvallate (folding on self).
    • Site of rupture - if obvious; low point of rupture suggests low-lying placenta.
  • Placental disc.
    • Fetal surface - normal is shinny.
      • Dull in chorioamnionitis.
    • Maternal surface
      • Are the cotyledons intact?
      • Adherent clot?
    • Parenchyma - after sectioning:
      • White vs. red nodules.

Notes:

Sections

  1. Cord two sections.
  2. Membranes (rolled), two rolls or more.[12]
  3. Cord at insertion + disc.
  4. Placenta - full thickness (maternal and fetal surface).
    • Sections should not be taken at the margin of the disc.

Placental membranes

Appearance:[13]

Placental mass

It is considered routine to obtain a mass for the placenta. This is usually done when the placenta is fresh and with the membranes and cord trimmed, as most tables of placental mass were created with these parameters.

Placental mass by gestational age:[15]

Gest. Age/Percentile 25% 50% 75%
32 weeks 275 g 318 g 377 g
36 weeks 369 g 440 g 508 g
40 weeks 440 g 501 g 572 g

Linear regression - placental mass-gestational age

Based on the table in the AFIP book[16] one can generate the following regression lines:

50% 10% 90%
slope (g/week) 21.58088235 19.70588235 25.40196078
y-intercept (g) -357.4558824 -397.2352941 -366.7254902
Pearson (r) 0.988670724 0.988268672 0.982206408

placental mass = slope x gestational age + intercept

What to remember...

Extrapolated from the linear regression (see above):

  • 50% at term = 500 grams.
  • 50% at 26 weeks = 200 grams.
  • The change in mass/week is approximately linear and equal to 300 grams / 14 weeks ~ 20 grams/week.
  • The spread in mass between 10% and 90%, crudely estimated, is 200 grams (for GA=26-40).

Notes:

  • Is it required?
    • Sebire and Fox have advocated abandoning the practise of obtaining a placental mass, due to the large number of uncontrolled variables inherent in these measures. Instead, they have advocated using mushy descriptors such as "small", "average" and "large", which require experience in examining the organ.[17]
      • In the context of quality, a measure (even if somewhat flawed) is probably more reproducible and objective than arbitrary descriptors which require experience and a continuing case volume to calibrate.

Placentomegaly

  • AKA large placenta.

Associations:[18]

Lame causes of a heavy placenta:

  • Dates wrong - error in determining the estimated date of confinement.
  • Adherent blood clot.

Comment:

  • Most of causes seem to have one thing in common:
    • There is a decreased oxygen delivery to the fetus.

Sign out

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CESAERIAN SECTION:
- LARGE PLACENTA (819 GRAMS -- TRIMMED, POST-FIXATION WEIGHT).
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.

Placental growth restriction

  • AKA placenta small for gestational age.
  • Small placenta redirects here.

Associations:

  • Maternal vascular disease, e.g. hypertension.
  • Fetal malformations.

Sign out

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- PLACENTA SMALL FOR GESTATIONAL AGE (160 GRAMS -- TRIMMED, POST-FIXATION WEIGHT).
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITH:
-- OLD CENTRAL TRANSMURAL INFARCT (1.7 CM MAXIMAL DIMENSION).

COMMENT:
The 10th percentile placental mass (pre-fixation) for 34 weeks and 2 days is approximately 390 grams.

Overview of placental pathology

Approach

The pathology of the placenta is diverse and is not easy to group.

It terms of remembering things. It is probably easiest to take a combined anatomical, etiologic and morphologic approach.

Anatomical basis:

  • Cord.
  • Membranes.
  • Disc.

Etiologic:

  • Congential.
  • Infectious.
  • Neoplastic.
  • Endocrine.
  • Trauma.
  • Vascular.
  • Degenerative.
  • Autoimmune.
  • Toxic.
  • Idiopathic.

Compartmental:

  • Vasculature.
  • Membranes.
  • Parenchyma:
    • Maternal part (decidua).
    • Fetal part (villi, cord).

Common entities/diagnoses

Sign out

What should be commented on...

  • Placenta:
    • Maturity of villi (2nd or 3rd trimester).
    • Infarction?
      • Subchorionic less important than maternal aspect.
      • Peripheral aspect of placental disc less important than central region of disc.
    • Blood vessels.
      • Maternal.
      • Fetal.
  • Membranes.
  • Cord:
    • 3 vessel?
    • Vasculitis/inflammation?

Mnemonic: chorio, cord, vessels, villi (maturity, infarction).

Normal placenta

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.

C-section

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CAESAREAN SECTION:
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.

Cord pathology

Two vessel umbilical cord

  • AKA two vessel cord.
  • AKA single umbilical artery.
Main article: Two vessel umbilical cord

Insertion

Marginal insertion

Definition:

  • The umbilical cord is attached to the placental disc at its margin.

Prevalence:

  • Approximately 12% of placentas.[21]

Relevance:

  • None according to WMSP.[21]
    • In theory, the cord, dependent on its relation to the internal os, is at greater risk of injury (leading to vasa previa) and compression (fetal hypoxia). A retrospective study found cord position in relation to the internal os is predictive for vasa previa.[22]

Velamentous insertion

Definition:

  • The umbilical cord inserts into the fetal membranes.[21]
    • The vessels are not protected by Wharton's jelly.
      • Wharton's jelly = the connective tissue surrounding the vessels in the cord.

Details:[21]

  • 3/4 of the time the vessel also branch; in the remaining 1/4 the vessels stay together.

Relevance:

  • Increased risk of vasa previa.[22]

Sign out

PLACENTA, UMBILICAL CORDS AND FETAL MEMBRANES, BIRTH:
- THREE VESSEL UMBILICAL CORD WITH A VELAMENTOUS INSERTION, OTHERWISE WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI WITHIN NORMAL LIMITS.

Umbilical knot

  • AKA umbilical cord knot.
  • AKA cord knot.
  • AKA true knot.

General

Gross

Work-up:[24]

  • Diameter measures and colour on both sides of the knot.
  • Knot should be untied to assess for deformation of Wharton's jelly.
  • Sections from both sides of the knot - to look for thrombi.

Note:

  • False knots (large diameter - focally) are common - they cannot be untied.

Microscopic

Features:

  • +/-Thrombi.
    • Fibrin deposition.
  • +/-Lines of Zahn.

Images:

Coiling

  • Hypo- and hypercoiling are both considered problematic.[21]
    • Normal: 1-3 coils/10 cm.[25]
  • Associated with cord stricture, which is usu. at the fetal end of the cord.[26]

Notes:

  • There is little uniformity in how coiling is assessed in the medical literature - though 10% and 90% are considered the cut-points for normal.[27]
    • What are the 10% and 90% cut-points? They are not given in WMSP. UT access to a journal article[28] that might have it is screwed-up.

Cord hematoma

Features:[26]

  • Rare ~ 1/5500.
  • Mortality ~50% is severe.

Membranes

Amnion nodosum

Main article: Amnion nodosum

Placental meconium

Main article: Placental meconium

Squamous metaplasia of the amnion

General

  • Benign common finding thought to be of no clinical significance.[29]
  • Needs to be separated from amnion nodosum - important.[31]

Gross

Features:[32]

  • White (or yellow) plaques - irregular outline.

DDx:

Images:

Microscopic

Features:[32]

  • Dense, paucicellular (pink) compact keratin - key feature.

Image:

Circumvallate placenta

  • AKA circumvallate insertion of the membranes.

General

Note:

  • Membranes usually attach to the edge of the placenta.

Gross

  • Fetal membranes attach to the fetal surface of the placenta away from the margin of the placental disc.

Classification:

  • Partial - not circumferential.
  • Complete.

DDx:

Images:

Twin placentas

Main article: Twin placentas

These are often submitted... even if they are normal. In these specimens, usually, the chorion is the key.

It covers:

  • Monozygotic vs. dizygotic twins.
  • Twin-to-twin transfusion syndrome.

Placental disc

Villous edema

General

  • Non-specific finding.
  • Reported in associated with congenital adrenal hyperplasia for the stem villi.[35]

Microscopic

Features:

  • "Swiss chesse-like" appearance / bubbly appearance.
  • Usually patchy and focal.

Note:

  • Cistern formation is reported in the stem villi in association with congenital adrenal hyperplasia.[35]

DDx:

Image:

Placental villous immaturity

Main article: Placental villous immaturity

Villous hypoplasia

  • AKA terminal villus deficiency.[37]
Main article: Villous hypoplasia

Diseases of the placental attachment

Placenta creta

Includes placenta accreta, placenta increta, and placenta percreta.

Main article: Placenta creta

Placental abruption

Main article: Placental abruption

Inflammatory pathologies

Overview of infections

General:[38]

Types

By site:[38]

  • Fetal membranes: chorioamnionitis, membranitis.[39]
  • Umbilical cord: funisitis.
  • Placenta: placentitis, villitis.

Membranitis

Chorionitis redirects here.

General

Microscopic

Features:

  • PMNs in the decidua.
  • +/-PMNs in subamniotic tissue.
  • +/-Necrosis in decidua or chorion/subamniotic tissue.

Note:

DDx:

Grading membranitis

Sternberg:[39]

  1. PMNs - decidua only.
  2. PMNs - in subamniotic tissue.
  3. 1 or 2 + necrosis in decidua or chorion/subamniotic tissue.

Sign out

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, CESAERIAN SECTION:
- FETAL MEMBRANES WITH CHORIONITIS.
- THREE VESSEL UMBILICAL CORD WITH VASCULITIS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.

Waffle

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- FETAL MEMBRANES WITH MECONIUM-LADEN MACROPHAGES AND ABUNDANT DECIDUAL NEUTROPHILS
  SUSPICIOUS FOR EARLY CHORIONITIS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI.
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.

Chorioamnionitis

Main article: Chorioamnionitis

Umbilical cord vasculitis

Main article: Umbilical cord vasculitis

Funisitis

Main article: Funisitis
  • Inflammation of Wharton's jelly - the connective tissue of the umbilical cord.

Acute villitis

Main article: Acute villitis

Villitis of unknown etiology

Main article: Villitis of unknown etiology

Chronic intervillitis

General

  • Rare.
  • Massive chronic intervillitis - associated IUGR, spontaneous abortion, perinatal fetal death.[42]
  • Recurs.

Microscopic

Features:[41][42]

  • Intervillous inflammatory cells:
    • Lymphocytes.
    • Histiocytes.
  • Fibrinoid deposition.

Images

  • Intervillitis - intermed. mag. (WC)

  • Intervillitis - very high mag. (WC)

Chronic deciduitis

  • AKA plasma cell deciduitis.
Main article: Chronic deciduitis

Placental infarction

True infarcts

Main article: Placental infarct

Perivillous fibrin deposition

  • Abbreviation PFD.

General

  • Thought to be an immunologic problem - resulting in platelet activation and fibrin deposition.[43]
  • May be associated with diabetes mellitus.[44]

Gross

  • Pale (white).
  • Firm.
  • White fibrous sepatae.

Microscopic

Features:

  • Acellular eosinophilic material around formed villi.
  • Obliteration of intervillous space.
    • Intervillous distance increased vis-a-vis normal - key feature.

Notes:

  • Nuclei of villi are usually preserved.
  • Villi may have secondary infarction, i.e. there may be nuclear destruction (karyolysis, karyorrhexis, pyknosis).

DDx:

Images:

Sign out

Thrombi

PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH:
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS.
- FETAL MEMBRANES WITHIN NORMAL LIMITS.
- PLACENTAL DISC WITH THIRD TRIMESTER VILLI AND THREE LARGE INTERVILLOUS 
THROMBI (BLOCKS A7-A9).

Maternal floor infarction

  • Abbreviated MFI.
  • Formally placental maternal floor infarction.
  • AKA massive perivillous fibrin deposition.[45]
Main article: Maternal floor infarction

Fetal disease

Fetal thrombotic vasculopathy

  • Abbreviated FTV.
  • A large number of terms are used for this including:[46]
    • Fibrinous vasculosis.
    • Fibromuscular sclerosis.
    • Fetal artery stem thrombosis.
  • The multitude of terms reflects the confusion about this finding and that it has numerous etiologies.[46]
Main article: Fetal thrombotic vasculopathy

Hemorrhagic endovasculitis

  • Abbreviated HEV.

General

  • Associated with stillbirth.[47]

Microscopic

Features:[48]

  • Walls of the (fetal) placental blood vessels (in the villi) are disrupted.
  • +/-Intraluminal necrotic debris.
  • RBC fragmentation.

Maternal disease

Hypertensive changes

General

Associated pathologic changes:[49]

  • Placental infarcts.
  • Increased syncytial knots.
  • Hypovascularity of the villi.
  • Cytotrophoblastic proliferation.
  • Thickening of the trophoblastic basement membrane.

Microscopic

Features:[49]

  • Enlarged endothelial cells - fetal capillaries.
  • Atherosis of the spiral arteries - placental bed (maternal).

Notes:

  • One should look for the changes in the membrane roll, not the maternal surface.[50]

Images:

Hypertrophic decidual vasculopathy

AKA decidual vasculopathy.
Main article: Hypertrophic decidual vasculopathy

HELLP syndrome

Main article: HELLP syndrome

Malaria

Main article: Malaria

General

  • Uncommon in Canada.
  • May lead to fetal demise.

Microscopic

Feature:

  • RBCs with basophilic dots ~1-2 micrometres.

Image

  • Maternal malaria - very high mag. (WC)

Tumours

Main article: Gestational trophoblastic disease

Chorangioma

Main article: Chorangioma

Chorangiomatosis

General

Associated with:

Gross

  • Multiple tan nodules.

Microscopic

Features:

  • Multiple chorangiomas - the difference between chorangioma and chorangiomatosis is not well defined.[51]

Images:

Chorangiosis

Main article: Chorangiosis

Other

Fetus papyraceus

  • May be spelled foetus papyraceus.
  • AKA fetus compressus.
Main article: Fetus papyraceus

Placental mesenchymal dysplasia

  • Abbreviated PMD.
Main article: Placental mesenchymal dysplasia

Placental cysts and pseudocysts

Types:[52]

  • Amnionic epithelial inclusion cyst (amniotic cyst).
  • Epidermal inclusion cyst - lined by keratinized squamous epithelium.
  • Chorionic cyst (AKA chorionic pseudocyts).
  • Cell island cyst.

Other considerations:[53]

  • Hematoma.
  • Fibrin-lined pseudocyst.

General:[53]

  • Usually good outcome.
  • Large cysts (>4.5 cm) or multiple cysts (>3) are associated with IUGR.

Images:

See also

References

  1. ↑ Sun, CC.; Revell, VO.; Belli, AJ.; Viscardi, RM. (Jun 2002). "Discrepancy in pathologic diagnosis of placental lesions.". Arch Pathol Lab Med 126 (6): 706-9. doi:10.1043/0003-9985(2002)1260706:DIPDOP2.0.CO;2. PMID 12033960.
  2. ↑ Yetter JF (March 1998). "Examination of the placenta". Am Fam Physician 57 (5): 1045–54. PMID 9518951.
  3. ↑ Hargitai B, Marton T, Cox PM (August 2004). "Best practice no 178. Examination of the human placenta". J. Clin. Pathol. 57 (8): 785–92. doi:10.1136/jcp.2003.014217. PMC 1770400. PMID 15280396. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770400/.
  4. ↑ URL: http://smj.sma.org.sg/5012/5012ra1.pdf. Accessed on: 11 February 2011.
  5. ↑ Sherman C. 8 February 2011.
  6. ↑ URL: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5069. Accessed on: 7 July 2010.
  7. ↑ 7.0 7.1 7.2 7.3 Sternberg, Stephen S. (1997). Histology for Pathologists (2nd ed.). Lippincott Williams & Wilkins. pp. 974. ISBN 978-0397517183.
  8. ↑ Sternberg, Stephen S. (1997). Histology for Pathologists (2nd ed.). Lippincott Williams & Wilkins. pp. 977. ISBN 978-0397517183.
  9. ↑ Narasimha, A.; Vasudeva, DS.. "Spectrum of changes in placenta in toxemia of pregnancy.". Indian J Pathol Microbiol 54 (1): 15-20. doi:10.4103/0377-4929.77317. PMID 21393870.
  10. ↑ URL: http://zulekhahospitals.com/uploads/files/Sub-chorionic.pdf. Accessed on: 17 August 2012.
  11. ↑ J Anat. Soc. India 49(2) 149-152 (2000). Available at: http://www.indmedica.com/anatomy/aindex1.cfm?anid=41. Accessed on: January 21, 2009.
  12. ↑ Winters R, Waters BL (December 2008). "What is adequate sampling of extraplacental membranes?: a randomized, prospective analysis". Arch. Pathol. Lab. Med. 132 (12): 1920–3. PMID 19061291.
  13. ↑ Lester, Susan Carole (2005). Manual of Surgical Pathology (2nd ed.). Saunders. pp. 461. ISBN 978-0443066450.
  14. ↑ CS. 7 February 2011.
  15. ↑ AFIP Placental pathol. ISBN: 1-881041-89-1. P.312
  16. ↑ AFIP Placental pathol. ISBN: 1-881041-89-1. P.312
  17. ↑ Fox, Harold; Sebire, Neil J. (2007). Pathology of the Placenta (Major Problems in Pathology) (3rd ed.). Saunders. pp. 559-561. ISBN 978-1416025924.
  18. ↑ URL: http://quizlet.com/5793113/ob-flash-cards/. Accessed on: 13 January 2012.
  19. ↑ Clarson, C.; Tevaarwerk, GJ.; Harding, PG.; Chance, GW.; Haust, MD.. "Placental weight in diabetic pregnancies.". Placenta 10 (3): 275-81. PMID 2771897.
  20. ↑ Hindmarsh, PC.; Geary, MP.; Rodeck, CH.; Jackson, MR.; Kingdom, JC. (Aug 2000). "Effect of early maternal iron stores on placental weight and structure.". Lancet 356 (9231): 719-23. PMID 11085691.
  21. ↑ 21.0 21.1 21.2 21.3 21.4 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 464. ISBN 978-0781765275.
  22. ↑ 22.0 22.1 Hasegawa J, Farina A, Nakamura M, et al. (December 2010). "Analysis of the ultrasonographic findings predictive of vasa previa". Prenat. Diagn. 30 (12-13): 1121–5. doi:10.1002/pd.2618. PMID 20872421.
  23. ↑ 23.0 23.1 Airas U, Heinonen S (April 2002). "Clinical significance of true umbilical knots: a population-based analysis". Am J Perinatol 19 (3): 127–32. doi:10.1055/s-2002-25311. PMID 12012287.
  24. ↑ 24.0 24.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 464. ISBN 978-0781765275.
  25. ↑ CS. 7 February 2011.
  26. ↑ 26.0 26.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 465. ISBN 978-0781765275.
  27. ↑ Khong TY (December 2010). "Evidence-based pathology: umbilical cord coiling". Pathology 42 (7): 618–22. doi:10.3109/00313025.2010.520309. PMID 21080869.
  28. ↑ PMID 16076615.
  29. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 463. ISBN 978-0781765275.
  30. ↑ Chew, RH.; Silberberg, BK. (Apr 1990). "Possible association of acute inflammatory exudate in chorioamnionitis and amniotic squamous metaplasia.". Am J Clin Pathol 93 (4): 582-5. PMID 2321592.
  31. ↑ CS. 7 February 2011.
  32. ↑ 32.0 32.1 32.2 Adeniran, AJ.; Stanek, J. (Dec 2007). "Amnion nodosum revisited: clinicopathologic and placental correlations.". Arch Pathol Lab Med 131 (12): 1829-33. doi:10.1043/1543-2165(2007)131[1829:ANRCAP]2.0.CO;2. PMID 18081444.
  33. ↑ URL: http://flylib.com/books/en/2.953.1.49/1/. Accessed on: 10 January 2011.
  34. ↑ Suzuki, S. (Feb 2008). "Clinical significance of pregnancies with circumvallate placenta.". J Obstet Gynaecol Res 34 (1): 51-4. doi:10.1111/j.1447-0756.2007.00682.x. PMID 18226129.
  35. ↑ 35.0 35.1 Furuhashi, M.; Oda, H.; Nakashima, T. (Sep 2000). "Hydrops of placental stem villi complicated with fetal congenital adrenal hyperplasia.". Arch Gynecol Obstet 264 (2): 101-4. PMID 11045335.
  36. ↑ URL: http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html. Accessed on: 28 May 2011.
  37. ↑ Baergen, Rebecca N. (2011). Manual of Pathology of the Human Placenta (2nd ed.). Springer. pp. 346. ISBN 978-1441974938.
  38. ↑ 38.0 38.1 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1106. ISBN 0-7216-0187-1.
  39. ↑ 39.0 39.1 Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Oberman, Harold A; Reuter, Victor E (2004). Sternberg's Diagnostic Surgical Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 2311. ISBN 978-0781740517.
  40. ↑ Vedovato, S.; Zanardo, V. (Jun 2010). "[Chorioamnionitis and inflammatory disease in the premature newborn infant].". Minerva Pediatr 62 (3 Suppl 1): 155-6. PMID 21090086.
  41. ↑ 41.0 41.1 Jacques, SM.; Qureshi, F. (Oct 1993). "Chronic intervillositis of the placenta.". Arch Pathol Lab Med 117 (10): 1032-5. PMID 8215826.
  42. ↑ 42.0 42.1 Rota, C.; Carles, D.; Schaeffer, V.; Guyon, F.; Saura, R.; Horovitz, J. (Nov 2006). "[Perinatal prognosis of pregnancies complicated by placental chronic intervillitis].". J Gynecol Obstet Biol Reprod (Paris) 35 (7): 711-9. PMID 17088773.
  43. ↑ Sebire, NJ.; Backos, M.; Goldin, RD.; Regan, L. (May 2002). "Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome.". BJOG 109 (5): 570-3. PMID 12066949.
  44. ↑ Baergen, Rebecca N. (2011). Manual of Pathology of the Human Placenta (2nd ed.). Springer. pp. 327. ISBN 978-1441974938.
  45. ↑ Baergen, Rebecca N. (2011). Manual of Pathology of the Human Placenta (2nd ed.). Springer. pp. 367. ISBN 978-1441974938.
  46. ↑ 46.0 46.1 Marchetti, D.; Belviso, M.; Fulcheri, E. (Mar 2009). "A case of stillbirth: the importance of placental investigation in medico-legal practice.". Am J Forensic Med Pathol 30 (1): 64-8. doi:10.1097/PAF.0b013e318187387e. PMID 19237859.
  47. ↑ Stevens NG, Sander CH (October 1984). "Placental hemorrhagic endovasculitis: risk factors and impact on pregnancy outcome". Int J Gynaecol Obstet 22 (5): 393–7. PMID 6151926.
  48. ↑ Sander CM, Gilliland D, Akers C, McGrath A, Bismar TA, Swart-Hills LA (February 2002). "Livebirths with placental hemorrhagic endovasculitis: interlesional relationships and perinatal outcomes". Arch. Pathol. Lab. Med. 126 (2): 157–64. PMID 11825110.
  49. ↑ 49.0 49.1 Soma H, Yoshida K, Mukaida T, Tabuchi Y (1982). "Morphologic changes in the hypertensive placenta". Contrib Gynecol Obstet 9: 58–75. PMID 6754249.
  50. ↑ Sherman, C. 7 February 2011.
  51. ↑ URL: http://path.upmc.edu/cases/case655/dx.html. Accessed on: 28 January 2012.
  52. ↑ Baergen, Rebecca N. (2011). Manual of Pathology of the Human Placenta (2nd ed.). Springer. pp. 219-220. ISBN 978-1441974938.
  53. ↑ 53.0 53.1 53.2 Brown, DL.; DiSalvo, DN.; Frates, MC.; Davidson, KM.; Genest, DR. (Jun 2002). "Placental surface cysts detected on sonography: histologic and clinical correlation.". J Ultrasound Med 21 (6): 641-6; quiz 647-8. PMID 12054300.

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