Syphilis
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Syphilis is the infectious disease caused by Treponema pallidum.
General
- Classically affects the testis before the epididymis.[1]
- Tuberculosis[2] and gonorrhea usually affect the epididymis before the testis.
- Considered one of the TORCH infections.
Gross
Aorta:
- Wrinkled intimal surface - "tree bark" appearance.[3]
Microscopic
Features:
- Plasma cells - key feature.[4]
- Spirochetes - diagnostic.
- +/-Granulomas[5] - gumma - in the tertiary phase.[6]
DDx:
- Plasma cell neoplasm.
- Reactive changes.
- Zoon balanitis.
- Other spirochetes, e.g. Borrelia burgdorferi.
Stains
Image
T. pallidum - very high mag. cropped. Dieterle stain. (WC)
T. pallidum - very high mag. Dieterle stain. (WC)
See also
- Vascular disease.
- Microorganisms.
- Intestinal spirochetosis.
- Inflammatory skin disorders.
- Granulomatous orchitis.
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 364. ISBN 978-0781765275.
- ↑ Das, P.; Ahuja, A.; Gupta, SD. (Jul 2008). "Incidence, etiopathogenesis and pathological aspects of genitourinary tuberculosis in India: A journey revisited.". Indian J Urol 24 (3): 356-61. doi:10.4103/0970-1591.42618. PMID 19468469.
- ↑ Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 80. ISBN 978-0521868792.
- ↑ Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 47. ISBN 978-1416054542.
- ↑ URL: http://pediatrics.aappublications.org/cgi/content/full/104/1/e4. Accessed on: 17 November 2010.