Plasma cell

From Libre Pathology
(Redirected from Plasma cells)
Jump to: navigation, search
A plasma cell.

The plasma cell is white blood cell that produces antibodies.

Microscopic

Features:

  • Ovoid intermediate-small cell size ~ 12 micrometers:
  • Eccentric nucleus.
    • Nucleus usu. hugs the cell membrane.
    • "Clock-face" chromatin pattern.
      • Small dots symmetrically rim the nuclear membrane - like the numbers on a clock.
  • Abundant cytoplasm.
    • Nucleus-to-cytoplasm ratio ~1:2
    • Perinuclear hof (prominent Gogli apparatus).
      • Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.

Note:

Images

Neoplasia

Neoplasms derived from plasma cell are called plasma cell neoplasms.

IHC

Others:

  • CD19 -ve.
  • CD20 -ve
  • CD56 -ve.

Lesions where plasma cells are important

Selected lesions with plasma cells

Neoplasms:

Inflammatory conditions:

Infectious:

Plasma cells are absent

See also

References

  1. 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 554. ISBN 978-0781765275.
  2. Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L (July 2010). "Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease". Inflamm Bowel Dis. doi:10.1002/ibd.21376. PMID 20629103.