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CD138, also known as Syndecan-1 (abbreviated SDC1),[1] is an immunostain that marks plasma cells.

It plays a role in angiogenesis and cellular proliferation.[2]



  • Adenocarcinoma - often positive in primaries from gastrointestinal tract, female reproductive organs and breast.[6]


See also


  1. Online 'Mendelian Inheritance in Man' (OMIM) 186355
  2. Guo, Q.; Yang, X.; Ma, Y.; Ma, L. (2015). "Syndecan-1 serves as a marker for the progression of epithelial ovarian carcinoma.". Eur J Gynaecol Oncol 36 (5): 506-13. PMID 26513873.
  3. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 554. ISBN 978-0781765275.
  4. Lim, GH.; Tan, PH.; Jara-Lazaro, AR.; Thike, AA.; Sim, WC.; Yap, VB.; Yip, GW. (Sep 2014). "Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival.". Singapore Med J 55 (9): 468-72. PMID 25273930.
  5. Zhang, W.; Jiang, YX.; Liu, Y.; Yu, WJ.; Zhao, H.; Li, YJ. (Jul 2013). "[Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases].". Zhonghua Bing Li Xue Za Zhi 42 (7): 433-7. PMID 24246859.
  6. 6.0 6.1 Chu, PG.; Arber, DA.; Weiss, LM. (Jul 2003). "Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 cases.". Am J Clin Pathol 120 (1): 64-70. doi:10.1309/48KC-17WA-U69B-TBXQ. PMID 12866374.