Search results

...ith simulated cases''' and '''interactive cases''', is a part of ''[[Libre Pathology]]'' that is focused on individual specimens. The cases presented usually do not exactly mirror the details behind the pictures. Th

.... If I am right, this case may have the [[chromosomal translocation]] seen in [[alveolar soft part sarcoma]].</center>}} ...of renal cell carcinoma in children; however, they are uncommon in adults. In adults they tend to have a poor prognosis.}}

===Other cases=== {{Cases navigation}}

===Other cases=== {{Cases navigation|state=collapsed}}

===Other cases=== {{Cases navigation|state=collapsed}}

[[Image: Urothelial carcinoma in situ -- intermed mag.jpg |500px|link=|center|]] {{hidden|High magnification|[[Image: Urothelial carcinoma in situ -- high mag.jpg |500px|link=|center|]]

| hcg= '''POSITIVE''' in multinucleated cells ===Other cases===

===Other cases=== {{Cases navigation}}

| ae1ae3= '''POSITIVE''' in the epithelial cells and plasmacytoid cells | ck7= '''POSITIVE''' in the epithelial cells and plasmacytoid cells

...n malignant potential''', abbreviated '''STUMP''', is smooth muscle lesion in which the behaviour (benign vs. malignant) cannot be ascertained with certa ...uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases |journal=Am. J. Surg. Pathol. |volume=33 |issue=7 |pages=992–1005 |year=2

===Other cases=== {{Cases navigation}}

| cd68= '''POSITIVE''' in foamy cells ===Other cases===

...ter>[[Pseudocarcinomatous urothelial hyperplasia]], [[Urothelial carcinoma in situ]], [[High-grade papillary urothelial carcinoma]], [[Low-grade papillar ...frequently involved by urothelial carcinoma. One syndrome that may be seen in the context of ureteral involvement is [[Lynch syndrome]].}}

...> Glypican 3 is can be positive in choriocarcinoma; it is usually positive in YST. ===Other cases===

...[[immunostain]] used in [[gastrointestinal pathology]] and [[genitourinary pathology]]. ...t4 = C. | last5 = Karagoz | first5 = F. | title = Expression of Glypican 3 in low and high grade urothelial carcinomas. | journal = Diagn Pathol | volume

===Other cases=== {{Cases navigation}}

===Other cases=== {{Cases navigation}}

{{hidden|More history|<center>Core biopsies 5 years ago had Gleason 6/10 in 2 cores, 5% of tissue, presented 1 month ago with gross hematuria, PSA 9.3 | ck7= '''POSITIVE''' in glandular areas, rare staining in spindled areas

{{hidden|Ask a colleague|<center>No idea. Did you look in the history?</center>}} ===Other cases===

===Other cases=== {{Cases navigation}}

===Other cases=== {{Cases navigation}}

...ther. Sister has a history of GI polyps. Patient mildly obese. Smoked when in her 20s. Cytoscopy shows a lesion on left lateral wall of the urinary bladd ...tain that is useful; in primary adenocarcinoma the nucleus is negative and in colorectal cancer it stains the nucleus.

...olleague|<center>Looks sarcomatoid. There used to be a [[sarcomatoid RCC]] in the WHO... but these are now classified by the identifiable RCC if one is p | ck7= strong '''POSITIVE''' (membranous) in epithelioid cells

===Other cases=== {{Cases navigation}}

In most cases it can be understood/used as a synonym for ''suspicious for malignancy''. In some classifications, it may be used when the pathologist cannot decide whe

...tic adenocarcinoma represents neuroendocrine differentiation: report of 30 cases. | journal = Hum Pathol | volume = 25 | issue = 2 | pages = 135-9 | month = [[Category:Genitourinary pathology]]

...unostains (AMACR negative, basal cells present (p63, CK5/6)) are important in this case. Morphologically, this is similar to [[foamy gland carcinoma|foam ===Other cases===

| fh= '''NEGATIVE''' in tumour ...ive behaviour. The definitive stain is FH (fumarate hydratase); it is lost in HLRCC. The IHC pattern doesn't fit [[papillary RCC]]; HLRCC is typically CK

...m the [[kidney]] to the [[urinary bladder]]. It is uncommonly afflicted by pathology that the pathologist sees on a day-to-day basis. =Pathology of the ureter - overview=

{{hidden|More history|<center>3.5 cm mass, radiology thinks it is RCC, smoker in teens and twenties, occasionally drinks alcohol, works a truck driver</cent ...]] (blue in ChRCC), and CK7 (strong membranous in ChRCC versus weak/patchy in oncocytoma) are quite useful.

...component in prostate cancer is common; one study identified it in ~15% of cases.<ref name=pmid9620026>{{Cite journal | last1 = Kaleem | first1 = Z. | last [[Category:Genitourinary pathology]]

[[Image: Benign clear cell clusters in the kidney -- intermed mag.jpg | thumb | [[Benign clear cell clusters of th ...are commonly seen in [[kidney tumours|tumours]] and occasionally are seen in benign lesions.

...F. | last8 = Zattoni | first8 = F. | title = Wunderlich's syndrome: three cases of acute spontaneous renal bleeding, conservatively treated. | journal = Ar It may be seen in:

*Very rare ~ 50 reported cases in 2002.<ref>{{Cite journal | last1 = Thiel | first1 = R. | last2 = Effert | ...Primary seminal vesicle carcinoma: an immunohistochemical analysis of four cases. | journal = Mod Pathol | volume = 13 | issue = 1 | pages = 46-51 | month =

...O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |is *Rare tumour: 12 in >500 renal cell carcinomas with clear cells.<ref name=pmid36592877/>

==Pathology== ...oma of epididymis: Is there a need for further investigation in unilateral cases? | journal = Int J Surg Case Rep | volume = 4 | issue = 7 | pages = 616-8 |

Comment:<br>This may occur in [[von Hippel-Lindau disease]]. In the context of von Hippel-Lindau disease, it is usually bilateral and the p ===Other cases===

| Image = Urothelial carcinoma in prostate - 2 -- high mag.jpg | Caption = Urothelial carcinoma and benign prostatic tissue in keeping with urethral urothelial carcinoma. [[H&E stain]]. (WC/Nephron)

{{hidden|More history|<center>No history of bladder cancer. UTI several times in the past year.</center>}} ===Other cases===

...'' article. An introduction to pediatric pathology is in the ''[[pediatric pathology]]'' article. Other renal tumours (not covered in this article):

===Other cases=== {{Cases navigation}}

'''Splenogonadal fusion''' is rare congenital pathology in which [[spleen|splenic tissue]] is fused to a gonad ([[testis]] or [[ovary] ...last4 = Chen | first4 = YJ. | title = Splenogonadal fusion: Report of four cases and review of the literature. | journal = Exp Ther Med | volume = 6 | issue

...oma of epididymis: Is there a need for further investigation in unilateral cases? | journal = Int J Surg Case Rep | volume = 4 | issue = 7 | pages = 616-8 | **One third of reported cases associated with vHL.<ref name=pmid20367315/>

...Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg P ...l and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying te

...found in a number of organs. Thus, it is important to have a list of 'em in one's head so one doesn't misdiagnose something. ==Clear cell in the name==

*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/> ...| last4 = Azawi | first4 = NH. | title = Amyloidosis in the bladder: three cases with different appearance. | journal = Scand J Urol | volume = 48 | issue =

*Only one case of metastases in 200 cases.<ref name=pmid7927308>{{cite journal |author=Eble JN |title=Spermatocytic s *Not reported/found in females.<ref name=pmid7927308/>

...a of the urinary bladder]], direct extension of non-bladder primary tumour in bladder (e.g. [[prostate cancer|prostate]], rectum, [[urachal carcinoma]]) | IHC = [[GATA3]] -ve/+ve (commonly +ve in breast), beta-catenin +ve/-ve (nuclear staining - suggests colorectal prima

...histoanatomic/urachal-remnant.cfm https://www.auanet.org/education/modules/pathology/bladder-histoanatomic/urachal-remnant.cfm]. Accessed on: 30 March 2015.</re ...chal cyst and review of the literature of 99 cases during a 10 year period in Japan] |language=Japanese |journal=Hinyokika Kiyo |volume=47 |issue=12 |pag

*+/-[[Urothelial carcinoma in situ]]. *p53 +ve/-ve. (+ve in ~60% of cases).

**May be seen in women. ...y a component of a [[mixed germ cell tumour]] - in the [[testicle]] 85% of cases are mixed, only 15% are pure.<ref name=pmid24503753/>

*Place in [[formalin]]. ...imens: a detailed anatomic and histologic study based on examination of 44 cases. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1091-4 |

In men, the [[urinary bladder]] is usually removed along with the [[prostate g ...ce of [[urothelial carcinoma in situ|CIS]] is strongly associated with CIS in the [[urinary bladder]].<ref name=pmid25374918>{{Cite journal | last1 = Zh

...changes, urothelial atypia of unknown significance, [[urothelial carcinoma in situ]] ...'''low-grade (urothelial) dysplasia''', is a lesion of the [[urothelium]] in the ISUP/WHO 2004 classification.<ref name=pmid19762067>{{Cite journal | l

*[http://path.upmc.edu/cases/case267.html Plasmacytoid UCC - several images (upmc.edu)]. ...othelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 42 | issue = 7 | pages

renal parenchyma (renal tubules or glomeruli) with in septations; +/-foamy histiocytes; +/-refractile material within the cysts *Usually an incidental finding (7 of 9 cases).

...mall as cancer, usu. lack nuclear hyperchromasia, two cell populations (as in normal prostate glands), basal cells may have [[nucleoli]] **Folds in gland lumina.

[[Image:Tissue for frozen section in cryostat.JPG|thumb|right|Tissue within a cryostat, as seen during an intrao ...ron | first8 = RM. | title = Indications and immediate patient outcomes of pathology intraoperative consultations. College of American Pathologists/Centers for

*Rare in pure form. *Most common GCT in infants and young boys.

| Caption = GATA3 staining in benign [[urothelium]]. | Subspecial = [[Genitourinary pathology]], [[Breast pathology]]

'''Malakoplakia''' is a thingy that typically arises in the [[urinary bladder]]. *Classically in the [[urinary bladder]].

.../practice, take a look at the ''[[quizzes]]'' page for quick ones, and ''[[cases]]'' page for longer ones. | [[Ameloblastoma]] || [[Head and neck pathology]] ||

...e urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi *cT1 disease treated by radical cystectomy in some centres.<ref name=pmid25254936>{{Cite journal | last1 = Willis | firs

...= Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. | journal = Br J Dermatol | volume = 147 | issue = 6 | pages = 1159-65 | m ...[[vulvar intraepithelial neoplasia]], that is based on the role of [[HPV]] in the pathogenesis.

| LMDDx = [[prostatic stromal sarcoma]], stromal nodule in [[benign prostatic hyperplasia]], [[leiomyosarcoma]], [[rhabdomyosarcoma]], ...e lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases. | journal = Am J Surg Pathol | volume = 22 | issue = 2 | pages = 148-62 |

*GATA3 ''positive'' and CK5/6 ''positive'' cases are classified as ''luminal''.<ref name=pmid34103388/> The immunoprofile (GATA3 POSITIVE, p16 POSITIVE, CK5/6 negative) is in keeping with UROTHELIAL CARCINOMA, LUMINAL TYPE, GENOMICALLY UNSTABLE.

*Prognosis good - based on one series of 11 cases.<ref name=pmid23708994/> May be seen in several contexts:<ref name=pmid23740406/>

...''' for [[renal cell carcinoma]]. A general discussion of staging is found in ''[[cancer staging]]''. | tumour in a caval thrombus below the diaphragm without invasion or adherence to the w

...inhorn | first6 = LH. | last7 = Donohue | first7 = JP. | title = Histology in mixed germ cell tumors. Is there a favorite pairing? | journal = J Urol | v ...crease in MGCTs over the past 20 years that is probably due to changes how in how [[germ cell tumours|GCT]]s are classified.<ref name=pmid21623833>{{Cite

...= Hansel | first7 = DE. | title = Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinoma. | journal = Urology | ...w-grade papillary urothelial carcinoma: a clinicopathologic analysis of 41 cases. | journal = Am J Surg Pathol | volume = 36 | issue = 7 | pages = 1081-6 |

.... | title = Update on corpus cavernosum smooth muscle contractile pathways in erectile function: a role for testosterone? | journal = J Sex Med | volume *Abnormal curvature of the penis, esp. in the erect state.

| Clinicalhx = lived in areas with ''Schistosoma haematobium'' Squamous differentiation in [[urothelial carcinoma]] is common and much more frequent than SCC of the b

...ine and make appearances in [[neuropathology]] (e.g. [[pineal gland]]) and in the [[mediastinum]]. ...in testicular tumors: report from the international society of urological pathology consensus conference |journal=Am. J. Surg. Pathol. |volume=38 |issue=8 |pag

[[Image:Small cell carcinoma in lymph node -- very high mag.jpg |thumb|300px|[[Micrograph]] showing a small ...f carcinoma. It is mostly commonly from the [[lung tumours|lung]]; 95% of cases are from the lung.<ref name=pmid21618245/>

*Male counterpart of the [[dysgerminoma]], which arise in the [[ovary]]. *Arises from ''[[germ cell neoplasia in situ]]'', abbreviated ''GCNIS'' (previously known as ''intratubular germ ce

**Median in one series of testicular choriocarcinoma ~ 200,000 IU.<ref name=pmid2414564 **Elevation may be seen in other (non-trophoblastic) tumours.<ref name=pmid7690985>{{Cite journal | l

The '''prostate gland''' adds juice to the sperm. In old men it creates a lot of problems... [[nodular hyperplasia]] (commonly c [[Prostate cancer]] is such a big topic it is dealt with in its own article.

...''prostate cancer staging'''. A general discussion about staging is found in ''[[cancer staging]]''. An introduction to ''prostate cancer'' is found in the [[prostate cancer]] article.

...n emerging entity that may be in the WHO classification of renal neoplasia in the future.<ref name=pmid31936678>{{cite journal |authors=Siadat F, Trpkov ...l Carcinoma (ChrRCC) and Oncocytoma. United States and Canadian Academy of Pathology Annual Meeting 2018.</ref>

#*Cells in cords/nests. (???) **In other words: the cortex may "spill" into the surrounding fat.

The '''urothelium''' lines the upper portion of the genitourinary tract, i.e. [[ureter]]s, [[urinary bladder]]), and a bit of the lower part. =====Urethra in males=====

...h_mag.jpg|thumb|right|200px|A positive surgical margin ([[ink]] on tumour) in [[urothelial carcinoma]]. [[H&E stain]].]] ...|thumb|200px|A positive surgical margin (tumour with [[cautery artifact]]) in [[colorectal carcinoma]]. [[H&E stain]].]]

...]. It is now in decline and uncommonly done. Fetal autopsy is dealt with in a separate article called ''[[fetal autopsy]]''. ...|author=Brian Gallagher, Burton EC, McDonald KM, Goldman L |title=Changes in rates of autopsy-detected diagnostic errors over time: a systematic review

...') and '''benign kidney tumours'''. Medical renal diseases are dealt with in the [[medical renal diseases]] article. Pediatric kidney tumours are dealt with in the ''[[pediatric kidney tumours]]'' article.

This article collects '''ditzels''', which are, in the context of [[pathology]], little specimens that are typically one or two slides and usually of lit The challenge in ditzels is not falling asleep... so one misses the unexpected (subtle) tumo

...y of the prostate gland, and prostate histology and anatomy are dealt with in the ''[[prostate gland]]'' article.

...als only with cervical cytopathology. An introduction to cytopathology is in the ''[[cytopathology]]'' article. ...the ''[[staining]]'' article and discussed in the context of cytopathology in the ''[[cytopathology]]'' article.

...ted nuclei (Pictures 1+2). There are no clear-cut cell borders discernible in light microscopy. This interveawing is called a syncytium. WHO Grading of t ...er language: German|Das H&E-Präparat zeigt Anteile eines mäßig zelldichten in Zügen und Wirbeln orientierten Tumors mit ovoid elongierten Tumorzellkerne

...e describes '''medical renal disease''' or the '''medical kidney'''. Much in medical kidney depends on the clinical information. Most of the disease se ...he area in pathology. In the context of exams for general pathologists, if in doubt... the answer to most questions is ''[[diabetes mellitus]]'' or ''[[s