Atrophic prostate carcinoma

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Atrophic prostate carcinoma is a type of prostate cancer that typically co-exists with conventional (acinar) prostate carcinoma. As its name implies, it has atrophic changes and can mimic (benign) prostate with atrophic changes.

General

  • Uncommon.

Note:

  • An atrophic component in prostate cancer is common; one study identified it in ~15% of cases.[1]

Microscopic

Features:

  • Scant cytoplasm.
  • Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
  • +/-Increased gland density.

DDx:

Images

IHC

  • p63 -ve.
    • Rare p63 +ve prostate carcinoma is reported.[2]

See also

References

  1. Kaleem, Z.; Swanson, PE.; Vollmer, RT.; Humphrey, PA. (Jun 1998). "Prostatic adenocarcinoma with atrophic features: a study of 202 consecutive completely embedded radical prostatectomy specimens.". Am J Clin Pathol 109 (6): 695-703. PMID 9620026.
  2. Wu, A.; Kunju, LP. (Sep 2013). "Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics.". Arch Pathol Lab Med 137 (9): 1179-84. doi:10.5858/arpa.2013-0254-CR. PMID 23991727.