Malakoplakia

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Malakoplakia
Diagnosis in short

Malakoplakia with numerous Michaelis-Gutmann bodies. H&E stain.

LM basophilic calcified bodies approximately the size of a RBC (Michaelis-Gutmann body) - inside or outside of macrophages, large foamy macrophages with granular cytoplasm +/- multinucleation, lymphocytes
LM DDx Xanthogranulomatous process (e.g. xanthogranulomatous pyelonephritis, xanthogranulomatous cystitis), granulomatous inflammation, papillary renal cell carcinoma, infarction (prostate), granular cell tumour
Gross yellow mass
Site urinary bladder and elsewhere

Prevalence uncommon
Endoscopy yellow lesion
Prognosis benign
Clin. DDx renal cell carcinoma, other tumours

Malakoplakia is a thingy that typically arises in the urinary bladder.

General

Gross

Microscopic

Features:[3]

  • Basophilic calcified lysosomes (Michaelis-Gutmann bodies) -- key feature.
    • May be inside or outside of macrophages - often size of RBC or larger.
  • Large foamy macrophages with granular cytoplasm.
  • Occasional multinucleated giant cell.
  • Lymphocytes.

DDx:

Images

Case

www

Stains

See also

References

  1. 1.0 1.1 Yousef, GM.; Naghibi, B.; Hamodat, MM. (Feb 2007). "Malakoplakia outside the urinary tract.". Arch Pathol Lab Med 131 (2): 297-300. doi:10.1043/1543-2165(2007)131[297:MOTUT]2.0.CO;2. PMID 17284117.
  2. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70719-7. Accessed on: 9 September 2010.
  3. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1027. ISBN 0-7216-0187-1.
  4. 4.0 4.1 Diapera, MJ.; Lozon, CL.; Thompson, LD.. "Malacoplakia of the tongue: a case report and clinicopathologic review of 6 cases.". Am J Otolaryngol 30 (2): 101-5. doi:10.1016/j.amjoto.2008.02.014. PMID 19239951.