Basal cell hyperplasia of the prostate

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Basal cell hyperplasia of the prostate
Diagnosis in short

Basal cell hyperplasia of prostate. H&E stain. (WC)

LM low power gland architecture near normal, glands usually not as small as cancer, usu. lack nuclear hyperchromasia, two cell populations (as in normal prostate glands), basal cells may have nucleoli
LM DDx urothelial metaplasia, prostate carcinoma
IHC basal presents (p63 +ve, CK34betaE12 +ve)
Site prostate gland

Signs none
Symptoms none
Prevalence common
Radiology none
Prognosis benign
Other incidental microscopic finding
Treatment none

Basal cell hyperplasia of the prostate, also known as basal cell hyperplasia, is a benign change of the prostate gland that may be misdiagnosed as prostate carcinoma.

General

  • Benign lesion that can be misdiagnosed as cancer.[1]

Microscopic

Features:[2]

  • Low power gland architecture near normal.[3][4]
    • Glands not as small as cancer.
    • Folds in gland lumina.
  • No nuclear hyperchromasia.
  • Two cell populations (as in normal prostate glands).
  • Basal cells may have nucleoli.

DDx:

Images

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  • Usually not reported.

See also

References

  1. Cleary, KR.; Choi, HY.; Ayala, AG. (Dec 1983). "Basal cell hyperplasia of the prostate.". Am J Clin Pathol 80 (6): 850-4. PMID 6195916.
  2. URL: http://pathologyoutlines.com/prostate.html#bch. Accessed on: 28 June 2010.
  3. URL: http://www.nature.com/modpathol/journal/v16/n6/fig_tab/3880810f1.html. Accessed on: 28 June 2010.
  4. URL: http://www.nature.com/modpathol/journal/v16/n6/fig_tab/3880810f2.html. Accessed on: 28 June 2010.
  5. McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.