Papillary cystadenoma of the epididymis|
This may occur in von Hippel-Lindau disease. In the context of von Hippel-Lindau disease, it is usually bilateral and the patient is younger.
The main (morphologic) differential diagnosis is clear cell renal cell carcinoma.
The immunoprofile of this lesion is like clear cell tubulopapillary renal cell carcinoma (also known as clear cell papillary RCC); it is CK7 positive, CD10 negative, AMACR negative, PAX8 positive. One should check if there is a kidney mass.
- ↑ Cox, R.; Vang, R.; Epstein, JI. (May 2014). "Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma.". Am J Surg Pathol 38 (5): 713-8. doi:10.1097/PAS.0000000000000152. PMID 24441657.