GFAP

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GLIAL FIBRILLARY ACIDIC PROTEIN, abbreviated GFAP,[1] was one of the first delevloped antibodies and is a common immunostain used in neuropathology. It's expression is associated with glial differentiation, especially with astrocytes.

Positive

Images

Negative

See[6]

  • Meningioma
  • Lymphoma
  • Carcinoma
  • Melanoma
  • Chordoma
  • Paraganglioma


See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 137780
  2. Anderson, MA.; Ao, Y.; Sofroniew, MV. (Apr 2014). "Heterogeneity of reactive astrocytes.". Neurosci Lett 565: 23-9. doi:10.1016/j.neulet.2013.12.030. PMID 24361547.
  3. Lolait, SJ.; Harmer, JH.; Auteri, G.; Pedersen, JS.; Toh, BH. (Oct 1983). "Expression of glial fibrillary acidic protein, actin, fibronectin and factor VIII antigen in human astrocytomas.". Pathology 15 (4): 373-8. PMID 6326028.
  4. Herpers, MJ.; Budka, H. (1984). "Glial fibrillary acidic protein (GFAP) in oligodendroglial tumors: gliofibrillary oligodendroglioma and transitional oligoastrocytoma as subtypes of oligodendroglioma.". Acta Neuropathol 64 (4): 265-72. PMID 6391068.
  5. Reifenberger, G.; Szymas, J.; Wechsler, W. (1987). "Differential expression of glial- and neuronal-associated antigens in human tumors of the central and peripheral nervous system.". Acta Neuropathol 74 (2): 105-23. PMID 3314309.
  6. Gottschalk, J.; Szymaś, J. (1987). "[Significance of immunohistochemistry for neuro-oncology. VI. Occurrence, localization and distribution of glial fibrillary acid protein (GFAP) in 820 tumors].". Zentralbl Allg Pathol 133 (4): 319-30. PMID 3425011.