Adenomatoid tumour

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Adenomatoid tumour
Diagnosis in short

Adenomatoid tumour. H&E stain.

LM small tubulocystic spaces lined by unremarkable mesothelium; the pseudotubular spaces are crossed by "thread-like bridging strands, usu. well-circumscribed
LM DDx lymphangioma, leiomyoma, vascular tumours
IHC calretinin +ve, CK7 +ve, AE1/AE3 +ve, WT1 +ve, CD31 -ve, desmin -ve
Site uterus, adnexa (fallopian tube/ovaries), others

Prevalence uncommon
Prognosis benign
Clin. DDx leiomyoma, other adenxal masses

Adenomatoid tumour is a rare benign tumour derived from the mesothelium.

It should not be confused with the bone tumour adamantinoma.

General

  • Grossly mimics leiomyoma.[1]
  • Benign tumour - derived from mesothelium.
  • May be seen paratesticular.[2]

Microscopic

Features:[3]

  • Well-circumscribed lesion; however, not encapsulated.
  • Small tubulocystic spaces lined by cytologically normal mesothelium.
    • These pseudotubular spaces are crossed by "thread-like bridging strands" - key feature.[4][5]

DDx:

Images

IHC

Features:[6]

  • Calretinin +ve.
  • AE1/AE3 +ve.
  • CK7 +ve.[7]

Others:[7]

  • CK20 -ve.
  • EMA -ve.
  • HMB-45 -ve.
  • Vimentin -ve.
  • Desmin -ve.
  • CD31 -ve.
  • CD34 -ve.
  • WT1 +ve.[8]

See also

References

  1. Huang, CC.; Chang, DY.; Chen, CK.; Chou, YY.; Huang, SC. (Sep 1995). "Adenomatoid tumor of the female genital tract.". Int J Gynaecol Obstet 50 (3): 275-80. PMID 8543111.
  2. González Resina, R.; Carranza Carranza, A.; Congregado Córdoba, J.; Conde Sánchez, JM.; Congregado Ruiz, CB.; Medina López, R. (Jan 2010). "[Paratesticular adenomatoid tumor: a report of nine cases].". Actas Urol Esp 34 (1): 95-100. PMID 20223139.
  3. Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 346. ISBN 978-0443069208.
  4. Sangoi, AR.; McKenney, JK.; Schwartz, EJ.; Rouse, RV.; Longacre, TA. (Sep 2009). "Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases.". Mod Pathol 22 (9): 1228-35. doi:10.1038/modpathol.2009.90. PMID 19543245.
  5. Hes, O.; Perez-Montiel, DM.; Alvarado Cabrero, I.; Zamecnik, M.; Podhola, M.; Sulc, M.; Hora, M.; Mukensnabl, P. et al. (Oct 2003). "Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors.". Ann Diagn Pathol 7 (5): 273-7. PMID 14571427.
  6. Canedo-Patzi, AM.; León-Bojorge, B.; de Ortíz-Hidalgo, C.. "[Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases]". Gac Med Mex 142 (1): 59-66. PMID 16548294.
  7. 7.0 7.1 Terada, T. (Mar 2012). "An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube.". Appl Immunohistochem Mol Morphol 20 (2): 173-6. PMID 22553816.
  8. Schwartz, EJ.; Longacre, TA. (Apr 2004). "Adenomatoid tumors of the female and male genital tracts express WT1.". Int J Gynecol Pathol 23 (2): 123-8. PMID 15084840.