Case 71

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Provided clinical history

62 year old man, progressive worsening of sob/cough

Site

Right lung biopsy

Primary image

Lung small cell carcinoma (2) by core needle biopsy.jpg
Low magnification. H&E stain.
Intermediate magnification 
Lung small cell carcinoma (1) by core needle biopsy.jpg
Intermediate magnification. H&E stain.


Differential diagnosis

Differential diagnosis 
small cell carcinoma of the lung, poorly differentiated carcinoma, basaloid squamous cell carcinoma of the lung, lymphoma, atypical carcinoid, other small round blue cell tumours, metastatic small cell carcinoma

Additional tests

More history

More history 
Patient has gynecomastia. Central lung mass of 4 cm - right lower lobe. CT head/abdo/pelvis shows no other mass lesion - but mediastinal lymphadenopathy. 40 pack year smoking history.

Ask a colleague

Ask a colleague 
This patient has a poor prognosis and is unlikely to be cured.

Stains

Alcian blue/PAS to Bilirubin
Test Result
Alcian blue/PASDr Torres would ask why!
Alican blue pH 1.0Dr Torres would ask why!
Alcian blue pH 2.5Dr Torres would ask why!
AuramineDr Torres would ask why!
BielchowskyDr Torres would ask why!
BilirubinDr Torres would ask why!
Colloidal iron to Fontana-Masson
Test Result
Colloidal ironDr Torres would ask why!
Congo redDr Torres would ask why!
Cresyl violetDr Torres would ask why!
DieterleDr Torres would ask why!
Diff QuikDr Torres would ask why!
Fontana-MassonDr Torres would ask why!
Gallyas to Gremelius
Test Result
GallyasDr Torres would ask why!
GiemsaDr Torres would ask why!
GMSDr Torres would ask why!
Gomori's trichromeDr Torres would ask why!
GramDr Torres would ask why!
GremeliusDr Torres would ask why!
JMS to Mucicarmine
Test Result
JMSDr Torres would ask why!
JonesDr Torres would ask why!
KinyounDr Torres would ask why!
Luxol fast blueDr Torres would ask why!
Masson trichromeDr Torres would ask why!
M-MASDr Torres would ask why!
MovatDr Torres would ask why!
MucicarmineDr Torres would ask why!
Oil red O to Prussian blue
Test Result
Oil red ODr Torres would ask why!
OreceinDr Torres would ask why!
PASDr Torres would ask why!
PASDDr Torres would ask why!
PASFDr Torres would ask why!
PTAHDr Torres would ask why!
Prussian blueDr Torres would ask why!
Reticulin to Ziehl-Neelsen
Test Result
ReticulinDr Torres would ask why!
Sudan black BDr Torres would ask why!
Toluidine blueDr Torres would ask why!
VerhoeffDr Torres would ask why!
Von KossaDr Torres would ask why!
Warthin-StarryDr Torres would ask why!
Ziehl-NeeslenDr Torres would ask why!

IHC

Alpha-1 AT to Cathepsin K
Test Result
alpha-1 AT Dr Torres would ask why!
ACTH Dr Torres would ask why!
AE1/AE1Dr Torres would ask why!
alpha-fetoprotein Dr Torres would ask why!
Alk-I Dr Torres would ask why!
AMACRDr Torres would ask why!
ARDr Torres would ask why!
ATRXDr Torres would ask why!
Beta2-microglobulin Dr Torres would ask why!
B72.3 Dr Torres would ask why!
Beta-cateninDr Torres would ask why!
BCL2 +ve
BCL6 Dr Torres would ask why!
BCLxL Dr Torres would ask why!
C3 comp Dr Torres would ask why!
CA9Dr Torres would ask why!
Calcitonin Dr Torres would ask why!
Calponin Dr Torres would ask why!
Calretinin +ve
CAM5.2Dr Torres would ask why!
Cathepsin KDr Torres would ask why!
CD10 to Chromogranin
Test Result
CD10 Dr Torres would ask why!
CD117 +ve
CD138Dr Torres would ask why!
CD15 Dr Torres would ask why!
CD1a Dr Torres would ask why!
CD20 NEGATIVE
CD21 Dr Torres would ask why!
CD23 Dr Torres would ask why!
CD3 NEGATIVE
CD30 Dr Torres would ask why!
CD31 Dr Torres would ask why!
CD34 Dr Torres would ask why!
CD35 Dr Torres would ask why!
CD4 Dr Torres would ask why!
CD43 Dr Torres would ask why!
CD45 (LCA)Dr Torres would ask why!
CD5 Dr Torres would ask why!
CD56 POSITIVE
CD57Dr Torres would ask why!
CD68 Dr Torres would ask why!
CD7 Dr Torres would ask why!
CD79a Dr Torres would ask why!
CD8 Dr Torres would ask why!
CD99 Dr Torres would ask why!
CDX2Dr Torres would ask why!
CEA-m Dr Torres would ask why!
Chromogranin POSITIVE
CK17 to Glypican 3
Test Result
CK17Dr Torres would ask why!
CK19Dr Torres would ask why!
CK20 NEGATIVE
CK34betaE12 Dr Torres would ask why!
CK5/6NEGATIVE
CK7 NEGATIVE
CMV Dr Torres would ask why!
c-MYC Dr Torres would ask why!
Cyclin D1 Dr Torres would ask why!
D2-40Dr Torres would ask why!
Desmin Dr Torres would ask why!
DOG1Dr Torres would ask why!
EBV Dr Torres would ask why!
EMADr Torres would ask why!
ER and PR Dr Torres would ask why!
Factor VIII Dr Torres would ask why!
Factor XIIIa Dr Torres would ask why!
Fascin Dr Torres would ask why!
FHDr Torres would ask why!
FSH Dr Torres would ask why!
Gastrin Dr Torres would ask why!
GATA3Dr Torres would ask why!
GCDFP-15 (BRST2)Dr Torres would ask why!
GFAPDr Torres would ask why!
GH Dr Torres would ask why!
Glucagon Dr Torres would ask why!
Glypican-3Dr Torres would ask why!
HBME-1 to IgM
Test Result
HBME-1 Dr Torres would ask why!
HBV core Dr Torres would ask why!
HBV surface Dr Torres would ask why!
H-caldesmonDr Torres would ask why!
HCG Dr Torres would ask why!
HelicobacterDr Torres would ask why!
Hepatocyte Dr Torres would ask why!
HER2/neu Dr Torres would ask why!
HHV-8Dr Torres would ask why!
HMB-45Dr Torres would ask why!
HNF1betaDr Torres would ask why!
HPV Dr Torres would ask why!
HSV-I Dr Torres would ask why!
HSV-II Dr Torres would ask why!
IDH-1Dr Torres would ask why!
Inhibin Dr Torres would ask why!
INI1 (BAF47)Dr Torres would ask why!
Insulin Dr Torres would ask why!
Kappa Dr Torres would ask why!
Ki-67 Dr Torres would ask why!
Lambda Dr Torres would ask why!
Leu 7 +ve
IgA Dr Torres would ask why!
IgG Dr Torres would ask why!
IgM Dr Torres would ask why!
LH to PDGFR
Test Result
LH Dr Torres would ask why!
LIN28 Dr Torres would ask why!
Lysozyme Dr Torres would ask why!
mammoglobinDr Torres would ask why!
MAP2Dr Torres would ask why!
MCVDr Torres would ask why!
Melanin A Dr Torres would ask why!
MHC class I Dr Torres would ask why!
MITFDr Torres would ask why!
MUM1Dr Torres would ask why!
Myeloperoxidase Dr Torres would ask why!
MYO D1 Dr Torres would ask why!
MyoglobinDr Torres would ask why!
NapsinDr Torres would ask why!
NFDr Torres would ask why!
NKX3.1Dr Torres would ask why!
NSE Dr Torres would ask why!
OCT3/4Dr Torres would ask why!
p16Dr Torres would ask why!
P501SDr Torres would ask why!
p53 Dr Torres would ask why!
p57Dr Torres would ask why!
p63 NEGATIVE
PankeratinPOSITIVE
PAX2Dr Torres would ask why!
PAX5Dr Torres would ask why!
PAX8Dr Torres would ask why!
PCNA Dr Torres would ask why!
PDGFRDr Torres would ask why!
PLAP to WT1
Test Result
PLAP Dr Torres would ask why!
PNL-2C Dr Torres would ask why!
Prolactin Dr Torres would ask why!
PSA Dr Torres would ask why!
PSAPDr Torres would ask why!
RCCDr Torres would ask why!
S-100Dr Torres would ask why!
SALL4Dr Torres would ask why!
Smooth muscle actin Dr Torres would ask why!
Somatostatin Dr Torres would ask why!
STAT6 Dr Torres would ask why!
Synaptophysin weakly POSITIVE
TdT Dr Torres would ask why!
TFE3Dr Torres would ask why!
TFEBDr Torres would ask why!
Thyroglobulin Dr Torres would ask why!
Toxoplasma Dr Torres would ask why!
TSH Dr Torres would ask why!
TTF-1 +ve
Ubiquitin Dr Torres would ask why!
UCHL1 (PGP9.5)Dr Torres would ask why!
Ulex Europaeus Dr Torres would ask why!
Vimentin-ve
VIP Dr Torres would ask why!
VZV Dr Torres would ask why!
WT-1Dr Torres would ask why!


Chromosomal translocations

Translocations Chr 1-10
Test Result
t(1;13) PAX7-FKHR Dr Torres would ask why!
t(2,13) PAX3-FKHR Dr Torres would ask why!
t(8;14) MYC-IGHDr Torres would ask why!
t(9;22) BCR-ABL Dr Torres would ask why!
t(9;22) CHN-EWS Dr Torres would ask why!
Translocations Chr 11-13
Test Result
t(11;14) CCND1-IGH Dr Torres would ask why!
t(11;22) EWS-WT1 Dr Torres would ask why!
t(11;22) FLI1-EWS Dr Torres would ask why!
t(12;15) ETV6-NTRK3 Dr Torres would ask why!
t(12;16) FUS-ATF1 Dr Torres would ask why!
t(12;16) CHOP-TLS Dr Torres would ask why!
t(12;22) EWS-ATF1 Dr Torres would ask why!
Translocations Chr 14-22
Test Result
t(14,18) IGH-BCL2 Dr Torres would ask why!
t(15;17) PML-RARA Dr Torres would ask why!
t(16;21) FUS-ERG Dr Torres would ask why!
t(17;22) COLA1-PDGFB Dr Torres would ask why!
t(21;22) EWS-ERG Dr Torres would ask why!
Translocations Chr X & Y
Test Result
t(X;1) PRCC-TFE3Dr Torres would ask why!
t(X;17) TFE3-ASPL Dr Torres would ask why!
t(X;18) SYT-SSX Dr Torres would ask why!


Diagnosis

Diagnosis 
small cell carcinoma


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