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Difference between revisions of "Lung tumours"
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*Adenocarcinoma is the most common (primary lung cancer).<ref>{{cite journal |author=Lutschg JH |title=Lung cancer |journal=N. Engl. J. Med. |volume=360 |issue=1 |pages=87-8; author reply 88 |year=2009 |month=January |pmid=19118313 |doi=10.1056/NEJMc082208 |url=}}</ref> | *Adenocarcinoma is the most common (primary lung cancer).<ref>{{cite journal |author=Lutschg JH |title=Lung cancer |journal=N. Engl. J. Med. |volume=360 |issue=1 |pages=87-8; author reply 88 |year=2009 |month=January |pmid=19118313 |doi=10.1056/NEJMc082208 |url=}}</ref> | ||
*Adenocarcinoma is the non-smoker tumour - SCLC and squamous are more strongly associated with [[smoking]]. | *Adenocarcinoma is the non-smoker tumour - SCLC and squamous are more strongly associated with [[smoking]]. | ||
Children: | |||
*Most common lung tumour in children: metastasis (80-85% of lung tumours in children<ref name=pmid>{{Cite journal | last1 = Dishop | first1 = MK. | last2 = Kuruvilla | first2 = S. | title = Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children's hospital. | journal = Arch Pathol Lab Med | volume = 132 | issue = 7 | pages = 1079-103 | month = Jul | year = 2008 | doi = 10.1043/1543-2165(2008)132[1079:PAMLTI]2.0.CO;2 | PMID = 18605764 }}</ref> | |||
**Most common primary tumours in children: [[inflammatory myofibroblastic tumour]], [[pleuropulmonary blastoma]], [[lung carcinoid]].<ref name=pmid26971789>{{Cite journal | last1 = Giuseppucci | first1 = C. | last2 = Reusmann | first2 = A. | last3 = Giubergia | first3 = V. | last4 = Barrias | first4 = C. | last5 = Krüger | first5 = A. | last6 = Siminovich | first6 = M. | last7 = Botto | first7 = H. | last8 = Cadario | first8 = M. | last9 = Boglione | first9 = M. | title = Primary lung tumors in children: 24 years of experience at a referral center. | journal = Pediatr Surg Int | volume = 32 | issue = 5 | pages = 451-7 | month = May | year = 2016 | doi = 10.1007/s00383-016-3884-3 | PMID = 26971789 }}</ref> | |||
===Distribution=== | ===Distribution=== | ||
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===Small cell carcinoma=== | ===Small cell carcinoma=== | ||
*TTF-1 +ve. | *[[TTF-1]] +ve. | ||
*[[CD56]] +ve - sensitive.<ref name=pmid16862075>{{cite journal |author=Hiroshima K, Iyoda A, Shida T, ''et al'' |title=Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis |journal=Mod. Pathol. |volume=19 |issue=10 |pages=1358-68 |year=2006 |month=October |pmid=16862075 |doi=10.1038/modpathol.3800659 |url=}}</ref> | *[[CD56]] +ve - sensitive.<ref name=pmid16862075>{{cite journal |author=Hiroshima K, Iyoda A, Shida T, ''et al'' |title=Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis |journal=Mod. Pathol. |volume=19 |issue=10 |pages=1358-68 |year=2006 |month=October |pmid=16862075 |doi=10.1038/modpathol.3800659 |url=}}</ref> | ||
*[[CK7]] -ve, [[CK20]] -ve. | *[[CK7]] -ve, [[CK20]] -ve. | ||
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Note: | Note: | ||
*CD56 - cytoplasmic.<ref>URL: [http://jcp.bmjjournals.com/content/58/9/978.full http://jcp.bmjjournals.com/content/58/9/978.full]. Accessed: 11 February 2010.</ref> | *CD56 - cytoplasmic.<ref>URL: [http://jcp.bmjjournals.com/content/58/9/978.full http://jcp.bmjjournals.com/content/58/9/978.full]. Accessed: 11 February 2010.</ref> | ||
===Adenocarcinoma=== | |||
*[[TTF-1]] +ve. | |||
*[[Napsin]] +ve - sensitive.<ref name=pmid22288963>{{cite journal |author=Turner BM, Cagle PT,Fukuoka J, ''et al'' |title=Napsin A, a New Marker for Lung Adenocarcinoma, Is Complementary and More Sensitive and Specific Than Thyroid Transcription Factor 1 in the Differential Diagnosis of Primary Pulmonary Carcinoma: Evaluation of 1674 Cases by Tissue Microarray |journal=Arch Pathol Lab Med. |volume=136 |issue=10 |pages=163-71 |year=2012 |month=February|pmid=22288963 |doi: 10.5858/arpa.2011-0320-OA|url=}}</ref> | |||
*[[CK7]] +ve, [[CK20]] -ve. | |||
===Squamous cell carcinoma=== | ===Squamous cell carcinoma=== | ||
*CK7 -ve, CK20 -ve. | *[[CK7]] -ve, CK20 -ve. | ||
*HMWK +ve. | *HMWK +ve. | ||
*Usually TTF-1 -ve.<ref>{{cite journal |author=Al-Zahrani IH |title=The value of immunohistochemical expression of TTF-1, CK7 and CK20 in the diagnosis of primary and secondary lung carcinomas |journal=Saudi Med J |volume=29 |issue=7 |pages=957-61 |year=2008 |month=July |pmid=18626520 |doi= |url=}}</ref> | *Usually TTF-1 -ve.<ref>{{cite journal |author=Al-Zahrani IH |title=The value of immunohistochemical expression of TTF-1, CK7 and CK20 in the diagnosis of primary and secondary lung carcinomas |journal=Saudi Med J |volume=29 |issue=7 |pages=957-61 |year=2008 |month=July |pmid=18626520 |doi= |url=}}</ref> | ||
*p40 +ve. | *[[p40]] +ve. | ||
===Primary vs. secondary=== | ===Primary vs. secondary=== | ||
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Note: | Note: | ||
*TTF-1 - should be nuclear staining; cytoplasmic staining is non-specific.<ref name=pmid15861215>{{cite journal |author=Compérat E, Zhang F, Perrotin C, ''et al.'' |title=Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin |journal=Mod. Pathol. |volume=18 |issue=10 |pages=1371–6 |year=2005 |month=October |pmid=15861215 |doi=10.1038/modpathol.3800422 |url=http://www.nature.com/modpathol/journal/v18/n10/full/3800422a.html}}</ref> | *TTF-1 - should be nuclear staining; cytoplasmic staining is non-specific.<ref name=pmid15861215>{{cite journal |author=Compérat E, Zhang F, Perrotin C, ''et al.'' |title=Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin |journal=Mod. Pathol. |volume=18 |issue=10 |pages=1371–6 |year=2005 |month=October |pmid=15861215 |doi=10.1038/modpathol.3800422 |url=http://www.nature.com/modpathol/journal/v18/n10/full/3800422a.html}}</ref> | ||
**Image: [http://commons.wikimedia.org/w/index.php?title=File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Nuclear staining with TTF-1 in a | **Image: [http://commons.wikimedia.org/w/index.php?title=File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Nuclear staining with TTF-1 in a primary lung adenocarcinoma (WC)]. | ||
==Neuroendocrine tumours== | ==Neuroendocrine tumours== | ||
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{{Main|Malignant mesothelioma}} | {{Main|Malignant mesothelioma}} | ||
== | ==Non-small cell lung carcinoma== | ||
*[[AKA]] ''poorly differentiated carcinoma of the lung''. | |||
{{Main|Non-small cell lung carcinoma}} | |||
- | |||
==Adenosquamous carcinoma of the lung== | |||
{{Main|Adenosquamous carcinoma of the lung}} | |||
==Lung metastasis== | ==Lung metastasis== | ||
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==Atypical carcinoid lung tumour== | ==Atypical carcinoid lung tumour== | ||
*[[AKA]] ''atypical carcinoid tumour of the lung''. | *[[AKA]] ''atypical carcinoid tumour of the lung''. | ||
{{Main|Atypical lung carcinoid tumour}} | |||
==Solitary fibrous tumour of the pleura== | ==Solitary fibrous tumour of the pleura== | ||
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=Benign tumours= | =Benign tumours= | ||
==Pulmonary apical cap== | |||
{{Main|Pulmonary apical cap}} | |||
A lesion that can mimic a lung neoplasm. | |||
==Pulmonary carcinoid tumourlet== | ==Pulmonary carcinoid tumourlet== | ||
*[[AKA]] ''carcinoid tumourlet''. | *[[AKA]] ''carcinoid tumourlet''. | ||
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*[[AKA]] ''clear cell sugar tumour''. | *[[AKA]] ''clear cell sugar tumour''. | ||
**Abbreviated ''CCST''. | **Abbreviated ''CCST''. | ||
{{Main|Clear cell sugar tumour of the lung}} | |||
=See also= | =See also= | ||