Napsin A
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Napsin A, also napsin, is a commonly used immunostain in pulmonary pathology.
Positive
- Lung adenocarcinoma - 83% of cases.[1]
- Papillary renal cell carcinoma 79% of cases.[1]
- Renal oncocytoma 57% of cases.[2]
Occasionally positive
- Clear cell renal cell carcinoma - 34% of cases.[1]
- Papillary thyroid carcinoma - 2/81 cases, tall cell variant only.[1]
- Clear cell tubulopapillary RCC - 47% of cases.[2]
Negative
- Squamous cell carcinoma of the lung.[1]
- Colorectal adenocarcinoma.[1]
- Pancreatic adenocarcinoma.[1]
- Breast carcinoma (0 positive of 17 cases[1]).
Napsin in pulomonary adenocarcinoma (WC/Yale Rosen)
Coarse Napsin staining pattern (WC/Yale Rosen)
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See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Bishop, JA.; Sharma, R.; Illei, PB. (Jan 2010). "Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma.". Hum Pathol 41 (1): 20-5. doi:10.1016/j.humpath.2009.06.014. PMID 19740516.
- ↑ 2.0 2.1 Zhu, B.; Rohan, SM.; Lin, X. (Mar 2015). "Immunoexpression of napsin A in renal neoplasms.". Diagn Pathol 10: 4. doi:10.1186/s13000-015-0242-z. PMID 25889632.