P40

From Libre Pathology
Jump to: navigation, search
P40
Immunostain in short

p40 immunostain in squamous cell carcinoma.
Similar stains p63 - less specific for squamous carcinoma than p40
Use lung (adenocarcinoma vs. squamous)
Normal staining pattern nuclear staining
Positive squamous cell carcinoma, urothelial carcinoma
Negative prostate carcinoma, most lung adenocarcinoma, most breast carcinoma

p40 an immunostain that is both sensitive and specific for squamous cell carcinoma. Like other "p" immunostains (e.g. p16, p63), it is a nuclear stain.

General

Staining

Positive

Images

Negative

See also

References

  1. Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
  2. Alomari, AK.; Glusac, EJ.; McNiff, JM. (Nov 2014). "p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma.". J Cutan Pathol 41 (11): 839-45. doi:10.1111/cup.12388. PMID 25263848.
  3. Brandler, TC.; Aziz, MS.; Rosen, LM.; Bhuiya, TA.; Yaskiv, O. (Jun 2014). "Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens.". Cancer Cytopathol 122 (6): 468-73. doi:10.1002/cncy.21424. PMID 24711443.
  4. Kővári, B.; Szász, AM.; Kulka, J.; Marušić, Z.; Šarčević, B.; Tiszlavicz, L.; Cserni, G. (Sep 2015). "Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions.". Pathobiology 82 (3-4): 166-71. doi:10.1159/000375127. PMID 26330357.
  5. Brustmann, H. (2015). "p40 as a Basal Cell Marker in the Diagnosis of Prostate Glandular Proliferations: A Comparative Immunohistochemical Study with 34betaE12.". Patholog Res Int 2015: 897927. doi:10.1155/2015/897927. PMID 25852959.