P40
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| P40 | |
|---|---|
| Immunostain in short | |
 p40 immunostain in squamous cell carcinoma. | |
| Similar stains | p63 - less specific for squamous carcinoma than p40 |
| Use | lung (adenocarcinoma vs. squamous) |
| Normal staining pattern | nuclear staining |
| Positive | squamous cell carcinoma, urothelial carcinoma |
| Negative | prostate carcinoma, most lung adenocarcinoma, most breast carcinoma |
p40 an immunostain that is both sensitive and specific for squamous cell carcinoma. Like other "p" immunostains (e.g. p16, p63), it is a nuclear stain.
General
- Considered superior to p63 as it is more specific.[1][2]
- p63 stains a significant number of adenocarcinomas.
Staining
Positive
Images
c/w HPV-SCC - p40 - intermed. mag. (WC/Nephron)
c/w HPV-SCC - p40 - high mag. (WC/Nephron)
Negative
- Lung adenocarcinoma.
- Breast carcinoma.
- CK5 +ve breast carcinomas are typically p40 positive.[4]
- Prostate carcinoma.[5]
See also
- p63.
References
- ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
- ↑ Alomari, AK.; Glusac, EJ.; McNiff, JM. (Nov 2014). "p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma.". J Cutan Pathol 41 (11): 839-45. doi:10.1111/cup.12388. PMID 25263848.
- ↑ Brandler, TC.; Aziz, MS.; Rosen, LM.; Bhuiya, TA.; Yaskiv, O. (Jun 2014). "Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens.". Cancer Cytopathol 122 (6): 468-73. doi:10.1002/cncy.21424. PMID 24711443.
- ↑ Kővári, B.; Szász, AM.; Kulka, J.; Marušić, Z.; Šarčević, B.; Tiszlavicz, L.; Cserni, G. (Sep 2015). "Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions.". Pathobiology 82 (3-4): 166-71. doi:10.1159/000375127. PMID 26330357.
- ↑ Brustmann, H. (2015). "p40 as a Basal Cell Marker in the Diagnosis of Prostate Glandular Proliferations: A Comparative Immunohistochemical Study with 34betaE12.". Patholog Res Int 2015: 897927. doi:10.1155/2015/897927. PMID 25852959.