Difference between revisions of "Diffuse lung diseases"

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Diffuse lung diseases (view source)

Revision as of 03:37, 18 April 2016

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→‎Respiratory bronchiolitis-interstitial lung disease: split out
 
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*Abbreviated ''RB-ILD'' or ''RBILD''.
*Abbreviated ''RB-ILD'' or ''RBILD''.
*[[AKA]] ''respiratory bronchiolitis-associated interstitial lung disease''.
*[[AKA]] ''respiratory bronchiolitis-associated interstitial lung disease''.
 
{{Main|Respiratory bronchiolitis-interstitial lung disease}}
===General===
*May be an early version of ''[[DIP]]''.
*Associated with smoking.
 
===Microscopic===
Features:<ref name=Ref_PPP197-8>{{Ref PPP|197-8}}</ref>
*Brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''.
**Cannot count (distinct) granules.
*Inflammation of the terminal bronchioles.
 
Note:
*The histologic features of RBILD may be present peri-tumoural.
*Hemosiderin-laden macrophages have coarse granules - that one can count.
 
DDx:
*[[Desquamative interstitial pneumonia]].
 
====Image====
*[http://www.nature.com/modpathol/journal/v19/n11/fig_tab/3800671f2.html RB-ILD (nature.com)].


==Desquamative interstitial pneumonia==
==Desquamative interstitial pneumonia==
*Abbreviated ''DIP''.
*Abbreviated ''DIP''.
===General===
{{Main|Desquamative interstitial pneumonia}}
*Thought to be advanced ''[[RBILD]]''.
*Strong association with smoking.<ref name=Ref_WMSP93>{{Ref WMSP|93}}</ref>
**Treatment: stop smoking.
 
===Microscopic===
Features:
*Abundant brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''.
*Architecture preserved; "linear fibrosis".
 
Notes:
*Some fields of view may be indistinguishable from [[RBILD]].
 
DDx:
*Amiodarone toxicity.
*Fibrotic [[NSIP]].
 
Images:
*[http://pathhsw5m54.ucsf.edu/case27/dip27.html DIP (ucsf.edu)].
 
===Stains===
*Macrophages [[PAS stain|PAS]] +ve.


=See also=
=See also=
Michael
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