Lymphocytic interstitial pneumonia

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Lymphocytic interstitial pneumonia
Diagnosis in short

Lymphocytic interstitial pneumonia. H&E stain.

LM small mature lymphocytes in the interstitium of the lung, plasma cells, +/-lymphoid follicles
LM DDx lymphoma - see lymphoma of lung, follicular bronchitis/bronchiolitis, nodular lymphoid hyperplasia
Site lung - see diffuse lung diseases

Associated Dx autoimmune disorders (rheumatoid arthritis, pernicious anemia, Sjoegren syndrome), viral infections (HIV, EBV, human T-cell leukemia virus (HTLV) type 1)
Clinical history dependent on underlying cause - see associated diagnoses
Prevalence rare
Radiology basilar predominance, increased interstitial markings

Lymphocytic interstitial pneumonia (abbreviated LIP), also known as lymphoid interstitial pneumonia and lymphocytic interstitial pneumonitis, is an uncommon diffuse lung disease.

General

Gross

  • Location: basilar predominance.
  • Increased interstitial markings.

Microscopic

Features:[4]

  • Small mature lymphocytes (usually B cells)[5] in the interstitium of the lung.
  • Plasma cells.
  • +/-Lymphoid follicles.

Negatives:

DDx:

Images

Case

www

Stains

To exclude infection:[6]

IHC

  • May be done to exclude lymphoma.

See also

References

  1. URL: http://emedicine.medscape.com/article/299643-overview. Accessed on: 2 June 2010.
  2. Nicholson AG (August 2001). "Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung". Semin Respir Crit Care Med 22 (4): 409–22. doi:10.1055/s-2001-17384. PMID 16088689.
  3. Turner, BJ.; Eppes, S.; McKee, LJ.; Cosler, L.; Markson, LE. (Jan 1995). "A population-based comparison of the clinical course of children and adults with AIDS.". AIDS 9 (1): 65-72. PMID 7893443.
  4. URL: http://emedicine.medscape.com/article/299643-diagnosis. Accessed on: 2 June 2010.
  5. AFIP atlas of nontumour pathology. 2002. Vo. 2. P.265. ISBN 1-881041-79-4.
  6. URL: http://path.upmc.edu/cases/case176/dx.html. Accessed on: 8 January 2012.