Drug toxicity, also drug reaction, in pathology is often a diagnosis of exclusion. Few drugs leave a distinctive histomorphologic pattern.
This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems.
A drug/toxin reaction should be considered if there is:
- An appropriate temporal relation.
- An empirical correlation between the drug/toxin and the pattern.
- Worsening with re-challenge.
- Improvement with removal of exposure.
- Pathologic pattern matches with toxin.
- Drug/toxin detected within individual.
Liver drug toxicity
Sodium polystyrene sulfonate
- AKA Kayexalate (trade name).
- Used to treat hyperkalemia.
Proton pump inhibitor
Nonsteroidal anti-inflammatory drugs
Oral contraceptive pill
- Abraham SC, Bhagavan BS, Lee LA, Rashid A, Wu TT (May 2001). "Upper gastrointestinal tract injury in patients receiving kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings". Am. J. Surg. Pathol. 25 (5): 637-44. PMID 11342776. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=25&issue=5&spage=637.