Proton pump inhibitor effect
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Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.
Formally, it is stomach with proton pump inhibitor effect.
- Due to intake of a proton pump inhibitor (PPI).
- Used to treat gastroesophageal reflux disease.
Some proton pump inhibitors
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- Parietal cell enlargement - key feature.
- Parietal cells typically bulge into the lumen.
- G cell and enterochromaffin cell-like hyperplasia.
- Compensatory change due to increased pH in gastric lumen.
- Multiple fundic gland polyps (with PPI use over several months).
- Polyps may regress after PPI is stopped.
- Usually not reported.