Proton pump inhibitor effect

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Stomach with PPI effect. H&E stain.

Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Formally, it is stomach with proton pump inhibitor effect.


Some proton pump inhibitors

Generic name Brand name(s)
Omeprazole LOSEC
Dexlansoprazole DEXILANT
Lansoprazole PREVACID
Esomeprazole NEXIUM
Pantoprazole PANTOLOC
Rabeprazole PARIET



  • Parietal cell enlargement - key feature.
    • Parietal cells typically bulge into the lumen.
  • G cell and enterochromaffin cell-like hyperplasia.
    • Compensatory change due to increased pH in gastric lumen.
  • Multiple fundic gland polyps (with PPI use over several months).
    • Polyps may regress after PPI is stopped.



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  • Usually not reported.

See also


  1. Driman, DK.; Wright, C.; Tougas, G.; Riddell, RH. (Oct 1996). "Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.". Dig Dis Sci 41 (10): 2039-47. PMID 8888719.
  2. topic/stomachPPI.html topic/stomachPPI