Difference between revisions of "Case 72"
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Low magnification. H&E stain.
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===Provided clinical history=== | ===Provided clinical history=== | ||
62 year old woman, Gross hematuria x 2 weeks | |||
===Site=== | ===Site=== | ||
Ureteral mass Bx | |||
===Primary image=== | ===Primary image=== | ||
[[Image: | [[Image: Nested variant of urothelial carcinoma - intermed mag.jpg |500px|link=|center|]] | ||
<center>Low magnification. [[H&E stain]].</center> | <center>Low magnification. [[H&E stain]].</center> | ||
{{hidden|Intermediate magnification|[[Image: | {{hidden|Intermediate magnification|[[Image: Nested variant of urothelial carcinoma - high mag.jpg |500px|link=|center|]] | ||
<center>Intermediate magnification. [[H&E stain]].</center>}} | <center>Intermediate magnification. [[H&E stain]].</center>}} | ||
{{hidden|High magnification|[[Image: | {{hidden|High magnification|[[Image: Nested variant of urothelial carcinoma - very high mag.jpg |500px|link=|center|]] | ||
<center>High magnification. [[H&E stain]].</center>}} | <center>High magnification. [[H&E stain]].</center>}} | ||
===Differential diagnosis=== | ===Differential diagnosis=== | ||
{{hidden|Differential diagnosis|<center> | {{hidden|Differential diagnosis|<center>[[Pseudocarcinomatous urothelial hyperplasia]], [[Urothelial carcinoma in situ]], [[High-grade papillary urothelial carcinoma]], [[Low-grade papillary urothelial carcinoma]], [[Prostate carcinoma]], [[Urothelial carcinoma]]</center>}} | ||
===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>Patient is 30 [[pack year]] smoker</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center>Distinguishing histologic variants may have clinical significance for this case</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 116: | Line 116: | ||
| cd99= | | cd99= | ||
| cdx2= | | cdx2= | ||
| cea= | | cea= +ve | ||
| chromo= | | chromo= | ||
| chromo= | | chromo= | ||
| ck17= | | ck17= | ||
| ck19= | | ck19= | ||
| ck20= | | ck20= +ve | ||
| ck34be12= | | ck34be12= | ||
| ck5_6= | | ck5_6= | ||
| ck7= | | ck7= +ve | ||
| cmv= | | cmv= | ||
| cmyc= | | cmyc= | ||
| Line 155: | Line 155: | ||
| hmb45= | | hmb45= | ||
| hnf1beta= | | hnf1beta= | ||
| hpv= | | hpv= -ve | ||
| hsv1= | | hsv1= | ||
| hsv2= | | hsv2= | ||
| Line 164: | Line 164: | ||
| ki67= | | ki67= | ||
| lambda= | | lambda= | ||
| leu7= | | leu7= -ve | ||
| lga= | | lga= | ||
| lgg= | | lgg= | ||
| Line 185: | Line 185: | ||
| p53= | | p53= | ||
| p57= | | p57= | ||
| p63= | | p63= +ve | ||
| panker= | | panker= | ||
| pax2= | | pax2= | ||
| Line 195: | Line 195: | ||
| pnl-2c= | | pnl-2c= | ||
| prolactin= | | prolactin= | ||
| psa= | | psa= -ve | ||
| psap= | | psap= -ve | ||
| rcc= | | rcc= | ||
| s100= | | s100= | ||
| Line 214: | Line 214: | ||
| vip= | | vip= | ||
| vzv= | | vzv= | ||
| wt1= | | wt1= -ve | ||
}} | }} | ||
====Chromosomal translocations==== | ====Chromosomal translocations==== | ||
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===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center> | {{hidden|Diagnosis|<center>[[Urothelial cell carcinoma]]</center> | ||
Comment:<br> | |||
The ureters are infrequently involved by urothelial carcinoma. One syndrome that may be seen in the context of ureteral involvement is [[Lynch syndrome]].}} | |||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
{{Cases navigation}} | {{Cases navigation}} | ||
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[[Category:Cases]] | [[Category:Cases]] | ||
[[Category:Cases]] | |||
[[Category:Cases in genitourinary pathology]] | [[Category:Cases in genitourinary pathology]] | ||
- | [[Category:Cases in genitourinary pathology - senior]] | ||
[[Category:Cases difficulty 4]] | |||
[[Category:Cases difficulty 4]] | |||
Latest revision as of 17:32, 3 October 2024
Provided clinical history
62 year old woman, Gross hematuria x 2 weeks
Site
Ureteral mass Bx
Primary image
Intermediate magnification
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High magnification
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Differential diagnosis
Additional tests
More history
More history
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Ask a colleague
Ask a colleague
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Stains
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IHC
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Chromosomal translocations
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Diagnosis
Diagnosis
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Comment: |