Difference between revisions of "Case 68"
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Low magnification. H&E stain.
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===Provided clinical history=== | ===Provided clinical history=== | ||
68 year old man, progressive sob of 6 month and unilateral chest pain of 3 months | |||
===Site=== | ===Site=== | ||
Lung Bx | |||
===Primary image=== | ===Primary image=== | ||
[[Image: | [[Image: Malignant epithelioid mesothelioma - low mag.jpg |500px|link=|center|]] | ||
<center>Low magnification. [[H&E stain]].</center> | <center>Low magnification. [[H&E stain]].</center> | ||
{{hidden|Intermediate magnification|[[Image: | {{hidden|Intermediate magnification|[[Image: Malignant epithelioid mesothelioma - intermed mag.jpg |500px|link=|center|]] | ||
<center>Intermediate magnification. [[H&E stain]].</center>}} | <center>Intermediate magnification. [[H&E stain]].</center>}} | ||
{{hidden|High magnification|[[Image: | {{hidden|High magnification|[[Image: Malignant epithelioid mesothelioma - high mag.jpg |500px|link=|center|]] | ||
<center>High magnification. [[H&E stain]].</center>}} | |||
{{hidden|Very High magnification|[[Image: Malignant epithelioid mesothelioma - very high mag.jpg |500px|link=|center|]] | |||
<center>High magnification. [[H&E stain]].</center>}} | <center>High magnification. [[H&E stain]].</center>}} | ||
===Differential diagnosis=== | ===Differential diagnosis=== | ||
{{hidden|Differential diagnosis|<center> | {{hidden|Differential diagnosis|<center>[[Fibrosing pleuritis]], [[Mesothelial hyperplasia]], [[Lung carcinoma]], [[Malignant mesothelioma]]</center>}} | ||
===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>No Smoking History. Hx of Asbestos exposure.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center>You should order a large immunohistochemistry panel of markers to distinguish from other tumors</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 57: | Line 60: | ||
| orecein= | | orecein= | ||
| pas= | | pas= | ||
| pasd= | | pasd= +ve | ||
| pasf= | | pasf= | ||
| ptah= | | ptah= | ||
| Line 80: | Line 83: | ||
| ar= | | ar= | ||
| b2microglobulin= | | b2microglobulin= | ||
| b72_3= | | b72_3= -ve | ||
| bcatenin= | | bcatenin= | ||
| bcl2= | | bcl2= | ||
| Line 88: | Line 91: | ||
| calcitonin= | | calcitonin= | ||
| calponin= | | calponin= | ||
| calretinin= | | calretinin= +ve | ||
| cam5p2= | | cam5p2= | ||
| cd10= | | cd10= | ||
| cd117= | | cd117= | ||
| cd138= | | cd138= | ||
| cd15= | | cd15= -ve | ||
| cd1a= | | cd1a= | ||
| cd20= | | cd20= | ||
| Line 116: | Line 119: | ||
| cd99= | | cd99= | ||
| cdx2= | | cdx2= | ||
| cea= | | cea= -ve | ||
| chromo= | | chromo= | ||
| chromo= | | chromo= | ||
| Line 123: | Line 126: | ||
| ck20= | | ck20= | ||
| ck34be12= | | ck34be12= | ||
| ck5_6= | | ck5_6= +ve | ||
| ck7= | | ck7= | ||
| cmv= | | cmv= | ||
| cmyc= | | cmyc= | ||
| cyclin_d1= | | cyclin_d1= | ||
| d2_40= | | d2_40= +ve | ||
| desmin= | | desmin= -ve | ||
| dog1= | | dog1= | ||
| ebv= | | ebv= | ||
| ema= | | ema= +ve | ||
| erpr= | | erpr= | ||
| f_viii= | | f_viii= | ||
| Line 183: | Line 186: | ||
| oct3_4= | | oct3_4= | ||
| p16= | | p16= | ||
| p53= | | p53= +ve | ||
| p57= | | p57= | ||
| p63= | | p63= | ||
| Line 207: | Line 210: | ||
| toxopl= | | toxopl= | ||
| tsh= | | tsh= | ||
| ttf1= | | ttf1= -ve | ||
| ubiquitin= | | ubiquitin= | ||
| uchl1= | | uchl1= | ||
| Line 214: | Line 217: | ||
| vip= | | vip= | ||
| vzv= | | vzv= | ||
| wt1= | | wt1= +1 | ||
}} | }} | ||
====Chromosomal translocations==== | ====Chromosomal translocations==== | ||
| Line 242: | Line 245: | ||
===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center> | {{hidden|Diagnosis|<center>[[Malignant mesothelioma]]</center>}} | ||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
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[[Category:Cases]] | [[Category:Cases]] | ||
[[Category:Cases in pulmonary pathology]] | |||
[[Category:Cases in | [[Category:Cases difficulty 2]] | ||
[[Category:Cases in pulmonary pathology - junior]] | |||
[[Category:Cases difficulty | |||
Latest revision as of 18:16, 5 July 2014
Provided clinical history
68 year old man, progressive sob of 6 month and unilateral chest pain of 3 months
Site
Lung Bx
Primary image
Intermediate magnification
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 |
High magnification
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 |
Very High magnification
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 |
Differential diagnosis
Differential diagnosis
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Additional tests
More history
More history
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Ask a colleague
Ask a colleague
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Stains
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IHC
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Chromosomal translocations
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Diagnosis
Diagnosis
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