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Difference between revisions of "Non-malignant skin disease"
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→Microscopic
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=Ref_Derm115>{{Ref Derm 115}}</ref> | ||
*A suprabasilar epidermal lesion consisting of "molluscum bodies", i.e. ''molluscum bodies'' are found above the stratum basale. | *A suprabasilar epidermal lesion consisting of "molluscum bodies", i.e. ''molluscum bodies'' are found above the stratum basale. | ||
*Molluscum bodies - '''key feature''': | **Molluscum bodies - '''key feature''': | ||
**Large cells with granular eosinophilic cytoplasmic inclusions. | ***Large cells with (granular) eosinophilic cytoplasmic inclusions. | ||
***The inclusions usually fill the cytoplasm. | ****The inclusions usually fill the cytoplasm. | ||
**** | ****Inclusions are usually one per cell... but may be multiple. | ||
**Small peripheral nucleus. | ***Small peripheral nucleus. | ||
*+/-Lymphocytes. | |||
Notes: | Notes: | ||
*Molluscum bodies very vaguely resemble ''[[signet ring cell]]s'' -- but: | *Molluscum bodies very vaguely resemble ''[[signet ring cell]]s'' -- but: | ||
**Cytoplasm is eosinophilic and granular. | **Cytoplasm is eosinophilic and granular. | ||
**Nucleus usually smaller than in signet ring | **Nucleus usually smaller than in signet ring cells. | ||
**''Molluscum bodies'' are only the epidermis - an uncommon place to find SRCs without finding them elsewhere. | **''Molluscum bodies'' are only in the epidermis - an uncommon place to find SRCs without finding them elsewhere. | ||
*The granular eosinophilic cytoplasmic inclusions represents accumulated virons. | *The granular eosinophilic cytoplasmic inclusions represents accumulated virons. | ||
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*[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_low_mag.jpg Molluscum contagiosum - low magnification (WC)]. | *[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_low_mag.jpg Molluscum contagiosum - low magnification (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_1.jpg Molluscum contagiosum (WC)]. | *[http://commons.wikimedia.org/wiki/File:Molluscum_contagiosum_1.jpg Molluscum contagiosum (WC)]. | ||
===Sign out=== | ===Sign out=== | ||
<pre> | <pre> | ||