Drug toxicity

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Drug toxicity, also drug reaction, in pathology is often a diagnosis of exclusion. Few drugs leave a distinctive histomorphologic pattern.

This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems.

General principles

A drug/toxin reaction should be considered if there is:

  1. Ingestion/exposure.
  2. An appropriate temporal relation.
  3. An empirical correlation between the drug/toxin and the pattern.
    • Worsening with re-challenge.
    • Improvement with removal of exposure.
    • Pathologic pattern matches with toxin.
    • Drug/toxin detected within individual.

Site specific

Liver drug toxicity

Stomach

Small bowel

Specific drugs

Sodium polystyrene sulfonate

AKA Kayexalate (trade name).

General

  • Used to treat hyperkalemia.

Microscopic

Features:[1]

Image

Proton pump inhibitor

Nonsteroidal anti-inflammatory drugs

Oral contraceptive pill

Minocycline

Spironolactone

See also

References