Necrobiosis lipoidica

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Necrobiosis lipoidica
Diagnosis in short

Necrobiosis lipoidica. HPS stain.

LM (dermal) palisading granulomas around necrotic collagen; little mucin; no normal dermis between foci; plasma cells - common; +/-involvement of subcutis
LM DDx granuloma annulare, rheumatoid nodule
Site skin

Associated Dx diabetes mellitus, rheumatoid arthritis
Prevalence uncommon

Necrobiosis lipoidica is an uncommon granulomatous skin pathology.

General

Associated with:

Gross

Image:

Microscopic

Features:[1]

  • Dermal palisading granuloma around:
    • Necrotic collagen - key feature.
      • Nuclei "missing" - have undergone karyolysis.
  • Little mucin, no normal dermis between foci.
  • Plasma cells - common.[2]
  • May involve adipose tissue.

DDx:

Images

www:

See also

References

  1. 1.0 1.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 51. ISBN 978-0443066542.
  2. 2.0 2.1 URL: http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html. Accessed on: 24 January 2012.