Angiokeratoma

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Angiokeratoma
Diagnosis in short

Angiokeratoma. H&E stain.

LM ectatic superficial dermal vessels with overlying hyperkeratosis (thick stratum corneum); should have "epidermal collarette" (vascular space is surrounded by epidermis on three sides)
LM DDx venous lake
Site skin

Syndromes Fabry disease

Prevalence uncommon
Prognosis benign
Clin. DDx melanocytic lesions, other vascular lesions

Angiokeratoma is a benign skin lesion.

General

Notes:

Gross

  • Dark lesions.

Clinical DDx:

Images

Microscopic

Features:[1]

  1. Ectatic superficial dermal vessels.
  2. Overlying hyperkeratosis (thick stratum corneum).
  • Should have "epidermal collarette".[2]
    • Vascular space surrounded by epidermis on three sides.

Others features:[citation needed]

DDx:

Images

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SKIN LESION, LEFT POPITEAL FOSSA, PUNCH BIOPSY:
- ANGIOKERATOMA.

See also

References

  1. 1.0 1.1 Karen, JK.; Hale, EK.; Ma, L. (2005). "Angiokeratoma corporis diffusum (Fabry disease).". Dermatol Online J 11 (4): 8. PMID 16403380.
  2. Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 548. ISBN 978-0443066542.
  3. Luzar, B.; Neil, SM.; Calonje, E. (May 2009). "Angiokeratoma-like changes in extragenital and genital lichen sclerosus.". J Cutan Pathol 36 (5): 540-2. doi:10.1111/j.1600-0560.2008.01091.x. PMID 19187108.