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'''Epithelioid cell lesions''' are very common in pathology. Malignant epithelioid lesions are *[[Small round cell tumours]].

| Micro = small (round) cells in nests with an undulating sharp border, road bands of paucicellula ...ar rhabdomyosarcoma]], [[embryonal rhabdomyosarcoma]], other [[small round cell tumours]]

*[[Small round cell tumour|Small round (blue) cell tumour]] with: *[[Small cell carcinoma]].

# Sampling is key -- choose 3-4 small pieces of tissue from different areas of the tissue (if there are different # Keep pieces small (easier to smear).

| Micro = [[small round blue cell tumour]] with focal cytoplasmic clearing +/-zonal necrosis ...ng sarcoma]], other [[Ewing-like tumours]], [[DSRCT]], other [[small round cell tumours]]

...hi VV, Roald B |title=Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee |jo ..., Smirniotopoulos JG |title=From the Archives of the AFIP. Pediatric orbit tumors and tumorlike lesions: osseous lesions of the orbit |journal=Radiographics

...rcoma - very high mag.jpg|thumb|right|[[Micrograph]] showing a small round cell tumour ([[Ewing sarcoma]]) in the lung. [[H&E stain]].]] '''Small round cell tumours''' (SRCT), also '''small round blue cell tumours''' (SRBCT), are a group of tumours that have a similar histologic a

...losa cell tumour'''. It should '''not''' be confused with the ''[[granular cell tumour]]''. ...ult granulosa cell tumour'' to avoid confusion with ''[[juvenile granulosa cell tumour]]''.

...1 = W. | last2 = Kleihues | first2 = P. | title = Genetic profiling of CNS tumors extends histological classification. | journal = Acta Neuropathol | volume ...KJ. | last4 = Burger | first4 = PC. | title = Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. | journal = Pediatr Dev Pat

| Caption = Lung small cell carcinoma. [[H&E stain]]. ...ed chromatin, high [[NC ratio]] with scant basophilic cytoplasm, typically small cells (~2x [[RBC]] diameter), +/-nuclear moulding, nuclei with smudgy appea

'''Sertoli-Leydig cell tumour''', also '''Sertoli-Leydig tumour''', is a rare tumour of the gonad ...| first6 = R. | last7 = Wu | first7 = L. | title = Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. | journal =

| Image = Eosinophilic, solid and cystic renal cell carcinoma -- low mag.jpg | Caption = Eosinophilic, solid and cystic renal cell carcinoma. [[H&E stain]].

| LMDDx = [[small round blue cell tumours]] ...was introduced in the WHO 2016 classification of CNS tumors. Some of these tumors of this category has been previously designated as '''CNS-PNET''' but this

| LMDDx = [[small round blue cell tumours]] ...this category has been replaced by the designation '''other CNS embryonal tumors'''.

| Micro = cellular tumour with small round cells usu. with a prominent nucleolus, rhabdoid cells (eosinophilic granula ...ncy, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the G

*Round. ==Location and cell types==

...ell sarcoma]], [[fibrosarcoma]], parosteal osteosarcoma, [[malignant giant cell tumour]], [[lymphoma]]. *[[Giant cell tumour of bone]].

| Micro = abundant eosinophilic cytoplasm, nuclei uniform and round without significant pleomorphism, solid or tubular architecture ...[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant, [[tubulocystic carcinoma of the kidney]], ot

| LMDDx = small cell round blue tumous. '''Medulloblastoma''' is a [[malignant]] [[small round cell tumour]] that is found in the [[cerebellum]] or dorsal brainstem. It is the

...lveolar RMS: alveolus-like pattern (classic); embryonal RMS: [[small round cell tumour]] | Subtypes = embryonal (spindle cell subtype, botryoid), alveolar (translocation-positive, translocation-negativ

...es of hemangiopericytoma, epitheliod glands or nests); (3) primitive round cell type ...= [[MPNST]], [[hemangiopericytoma]], [[fibrosarcoma]], [[small round cell tumours]], carcinoma

| Site = [[stomach]], [[small intestine]], other sites ...cite journal |author=Miettinen M, Lasota J |title=Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential dia

| Caption = Chief cell parathyroid adenoma (left of image) and unremarkable parathyroid gland (rig | Subtypes = chief cell, oxyphil, mixed

...pheral_nerve_sheath_tumour_-_very_high_mag.jpg|thumb|right|250px|A spindle cell lesion ([[MPNST]]). [[H&E stain]].]] '''[[Spindle cell]] lesions''' are seen frequent enough that one ought to have a solid approa

| LMDDx = [[embryonal carcinoma]], [[GCNIS]], [[mixed germ cell tumour]], [[granulomatous orchitis]], [[testicular scar]], [[atrophic testi | ClinDDx = other [[testis|testicular tumours]] ([[germ cell tumour]]s, [[lymphoma]])

#They are small specimens ~ usually 1-10 ml. *Ocassionally arachnoid cap cell-

| round, small | round / polyhedral

*Germ cell tumours: **Usu. +ve in germ cell tumours.

...Park | first1 = YN. | last2 = Roncalli | first2 = M. | title = Large liver cell dysplasia: a controversial entity. | journal = J Hepatol | volume = 45 | is *[[Small liver cell dysplasia]] ([[AKA]] small cell dysplasia).

...filled with basophilic material, scant cytoplasm in most cells, nucleus - small, hyaline stroma ...| title = European results in neutron therapy of malignant salivary gland tumors. | journal = Bull Cancer Radiother | volume = 83 Suppl | issue = | pages =

| Synonyms = pancreatic islet cell tumour (obsolete term) | LMDDx = [[solid pseudopapillary neoplasm]], [[acinar cell carcinoma]], [[invasive ductal carcinoma of the pancreas]]

| Caption = Basal cell carcinoma. [[H&E stain]]. ...c keratosis]] (for BCC, fibroepitheliomatous pattern), [[basaloid squamous cell carcinoma]], [[basosquamous carcinoma]]

...eased stromal cellularity, +/-nuclear atypia, +/-benign glands, lack small round blood vessels, no necrosis, no or minimal mitotic activity ...ontgomery | first3 = E. | last4 = Epstein | first4 = JI. | title = Spindle cell lesions of the adult prostate. | journal = Mod Pathol | volume = 20 | issue

The '''duodenum''' is the first part of the [[small bowel]] and receives food from the [[stomach]]. It is accessible by EGD (e *Predominant lamina propria cell: [[plasma cells]].

*It is important to consider [[germ cell tumour]]s in the DDx as these may be curable with chemotherapy. *Clear cell variant of HCC may be misdiagnosed as metastatic [[clear cell carcinoma]].

| LMDDx = [[serous carcinoma]] from other sites, [[clear cell carcinoma of the ovary]], poorly differentiated [[endometrioid carcinoma of ...l | first7 = JR. | title = The malignant potential of small cystic ovarian tumors in women over 50 years of age. | journal = Gynecol Oncol | volume = 69 | is

It consists of two cell types:<ref name=Ref_PBoD8_1159>{{Ref PBoD8|1159}}</ref> ...ction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases. | journal = Am J Surg Pathol | volume = 35

| Image = Chromophobe renal cell carcinoma -- high mag.jpg | Caption = Chromophobe renal cell carcinoma showing the characteristic perinuclear clearing and distinctive (

...ells may be scarce); epidermoid cells (non-keratinized, polygonal squamoid cell with clear or oncocytic cytoplasm); architecture - cystic (low grade) or so | LMDDx = [[squamous cell carcinoma of the head and neck]], [[adenosquamous carcinoma]], [[pleomorphi

*Spindle cell lesion. *Very many small capillaries of irregular shape lined with:

...testine_-_ck20_-_intermed_mag.jpg||thumb|400px|[[CK20]] staining of normal small intestinal mucosa.]] **FastRed stains are more suited in melanocytic tumors than DAB.

*[[Glycogen-rich clear cell carcinoma of the breast|Glycogen-rich clear cell carcinoma]]. *[[Acinic cell carcinoma]].

*Papers with very small sample sizes abound. ...| title = Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential. | journal =

...[[Nuclear pseudoinclusions]], Picture 4+5) are typical cut phenomenon. The round calcified inclusions ([[Psammoma bodies]]) are characteristic for a [[menin ...inieren, was als pseudosynzytialer Aspekt bezeichnet wird. Die Wertung des Tumors nach WHO ist abhängig von der mitotischen Aktivität (Bild 3), oder durch

*Fasciculations - small involuntary muscle contraction, imply lower motor neuron lesion. * Punch biopsies (3mm) for small fiber neuropathy.

...eritoneal [[sarcoma]] (esp. [[leiomyosarcoma]] & [[liposarcoma]]), [[renal cell carcinoma with sarcomatoid differentiation]], [[renal leiomyoma]] *Small resected AML are often fat poor.

#*[[Renal cell carcinoma]] (RCC). * [[Granular cell tumour]].

Some tumours are classically cystic with a small solid component (so-called cyst with a mural nodule) -- e.g. pilocytic astr **Nucleus and Nissl substance are pushed to cell periphery.

...= major criteria: abnormal architecture (increased gland density, usu. small circular glands, "infiltrative growth" pattern), basal cells lost, cytologi ...phy]], [[seminal vesicle]], [[basal cell hyperplasia of the prostate|basal cell hyperplasia]], others