Difference between revisions of "Placenta"

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*Associated with:
*Associated with:
**Intrauterine growth restriction.  
**Intrauterine growth restriction.  
**Recurrent reproductive loss -- '''key point'''.
**Recurrent reproductive loss/adverse outcomes in subsequent pregnancies -- '''key point'''.
***Recurrence in up 37% of cases.<ref name=pmid20604650>{{cite journal |author=Feeley L, Mooney EE |title=Villitis of unknown aetiology: correlation of recurrence with clinical outcome |journal=J Obstet Gynaecol |volume=30 |issue=5 |pages=476–9 |year=2010 |pmid=20604650 |doi=10.3109/01443611003802339 |url=}}</ref>


Etiology:
Etiology:

Revision as of 18:45, 10 February 2011

The placenta feeds the developing baby, breathes for it and disposes of its waste.

Clinical

Examination of the placenta

  • Most placentas are not examined by a pathologist.

Indications for exam by pathology

Some indications for exam by a pathologist:

  • Abnormalities in the:
    1. Fetus:
      • Bad fetal outcome.
      • Suspected or known congenital abnormalities or chromosomal abnormalities.
    2. Mother:
      • Infection/suspected infection.
      • Pre-term labour.
      • Maternal disease (e.g. SLE, coagulopathy).
      • Complicated pregnancy (preclampsia, pregnancy induced hypertension, gestational diabetes).
    3. Placenta:
      • Unusual gross characteristics.[1]

A more detailed list is given by Hargitai et al.[2] and Chang.[3]

Most common

Most common reasons for submitting a placenta to pathology:[4]

  1. Prematurity.
  2. PROM / possible chorioamnionitis.
  3. Multiple gestation.

Bleeding in late pregnancy

DDx of bleeding in late pregnancy:

  • Placental abruption (most common).
  • Placenta previa.
  • Vasa previa (fetus losing blood).

Clinical screening tests

  • PAPP-A - low values seen in aneuploidy.[5]

Normal histology

Villi

This is dealt with in a separate article that also covers the types of trophoblast (cytotrophoblast, syncytiotrophoblast, intermediate trophoblast).

Cord

Omphalomesenteric duct remnant

  • AKA vitelline duct.
  • Benign embryologic remnant.

Features:

  • Duct with benign looking cuboidal epithelium.

Allantoic duct remnant

  • Benign embryologic remnant.

Features:

  • Duct with benign looking flat epithelium.

Vitelline artery remnant

Features:

  • Small artery in the cord.

Membranes

Amnion

General:

  • Next to fetus, surrounds amniotic fluid, avascular.

Characteristics:

  • Characterized by a single layer of cells.[6]
    • Cuboidal/squamoid shape.
    • Eosinophilic cytoplasm.
    • Central nucleus.
  • Squamous metaplasia may be seen at cord insertion.
  • Basement membrane.
  • 'Compact layer'.[6]
  • 'Fibroblastic layer'.[6]

Chorion

General:

  • Surrounds amnion.

Characteristics:

  • Layers:[7]
    • 'Reticular layer' - cellular (inner aspect).
    • 'Pseudo-basemement membrane'.
    • 'Outer trophoblastic layer'.
  • Has blood vessels.
  • Opposed to "trophoblastic X cells" on side opposite of amnion.[6]
    • Beneath of the "trophoblastic X cells" is decidua (mnemonic NEW = nucleus central, eosinophilic, well-defined cell border), which is maternal tissue.

Common terms

  • Chorionic plate - fetal aspect of placenta.
  • Basal plate - maternal aspect of placenta.
    • Has extravillous trophoblast.
    • Place to look for maternal vessels.

Grossing

This is often very quick. The gross is quite important, as some things cannot be diagnosed microscopically.

General

  • Dimensions:
    • Disc.
    • Length of cord, diameter of cord.
    • Accessory lobes - dimensions.
      • Two lobes of equal size + cord arises in between = bilobate placenta.
  • Mass (weight).
    • Should be done 'trimmed' (cord cut-off, membrane cut-off).
    • Should be done when placenta is "fresh", i.e. not fixed -- as mass tables are based on fresh state.
  • Umbilical cord
    • Attachment.
      • Location: central, eccentric, marginal.
        • Marginal attachment assoc. with hypertension[8]
      • Membranous or velamentous (veil-like) insertion.
        • Vessels separate/branch prior to reaching placental disc.
      • Furcate insertion - vessel run on fetal surface (more exposed to trauma).
    • Knots (false vs. true).
      • False knots are nothing to worry about -- look like a knot but aren't really one.
    • Twisting/coiling - 1-3 coils/10 cm is normal.
    • Number of vessels.
      • Normal: 2 arteries, 1 vein.
  • Membranes - shiny & translucent - normal (green, opaque/dull - chorioamnionitis).
    • Attachment: marginal (normal), circummarginate (inside edge), circumvallated (folding on self).
    • Site of rupture - if obvious; low point of rupture suggests low-lying placenta.
  • Placental disc.
    • Fetal surface - normal is shinny.
      • Dull in chorioamnionitis.
    • Maternal surface
      • Are the cotyledons intact?
      • Adherent clot?
    • Parenchyma - after sectioning:
      • White vs. red nodules.

Notes:

  • Parenchymal nodules - a brief DDx:
    • White: infarct (chronic), thrombi, chorangioma, perivillous fibrin deposition.
    • Red: infarct (acute), thrombi.

Sections

  1. Cord two sections.
  2. Membranes (rolled), two rolls or more.[9]
  3. Cord at insertion + disc.
  4. Placenta - full thickness (maternal and fetal surface).
    • Sections should not be taken at the margin of the disc.

Placental membranes

Appearance:[10]

  • Normal - shiny.
  • Choriomnionitis - opaque/dull.
  • Meconium - green.
  • Amnion nodosum - yellow patches.
    • Some describe 'em as white.[11]

Placental mass

It is considered routine to obtain a mass for the placenta. This is usually done when the placenta is fresh and with the membranes and cord trimmed, as most tables of placental mass were created with these parameters.

Placental mass by gestational age:[12]

Gest. Age/Percentile 25% 50% 75%
32 weeks 275 g 318 g 377 g
36 weeks 369 g 440 g 508 g
40 weeks 440 g 501 g 572 g

Linear regression - placental mass-gestational age

Based on the table in the AFIP book[13] I generated the following regression lines:

50% 10% 90%
slope (g/week) 21.58088235 19.70588235 25.40196078
y-intercept (g) -357.4558824 -397.2352941 -366.7254902
Pearson (r) 0.988670724 0.988268672 0.982206408

placental mass = slope x gestational age + intercept

What to remember...

Extrapolated from the linear regression (see above):

  • 50% at term = 500 grams.
  • 50% at 26 weeks = 200 grams.
  • The change in mass/week is approximately linear and equal to 300 grams / 14 weeks ~ 20 grams/week.
  • The spread in mass between 10% and 90%, crudely estimated, is 200 grams (for GA=26-40).

Notes:

  • Is it required?
    • Sebire and Fox have advocated abandoning the practise of obtaining a placental mass, due to the large number of uncontrolled variables inherent in these measures. Instead, they have advocated using mushy descriptors such as "small", "average" and "large", which require experience in examining the organ.[14]
      • In the context of quality, a measure (even if somewhat flawed), is almost certainly more reproducible than arbitrary descriptors which require experience and a continuing case volume to calibrate.

Overview of placental pathology

Approach

The pathology of the placenta is diverse and is not easy to group.

It terms of remembering things. It is probably easiest to take a combined anatomical, etiologic and morphologic approach.

Anatomical basis:

  • Cord.
  • Membranes.
  • Disc.

Etiologic:

  • Congential.
  • Infectious.
  • Neoplastic.
  • Endocrine.
  • Trauma.
  • Vascular.
  • Degenerative.
  • Autoimmune.
  • Toxic.
  • Idiopathic.

Compartmental:

  • Vasculature.
  • Membranes.
  • Parenchyma:
    • Maternal part (decidua).
    • Fetal part (villi, cord).

Common entities/diagnoses

  • Normal.
  • Chorioamnionitis.
  • Placental abruption.
  • Meconium.
  • Hypertensive changes.

Sign-out

What should be commented on...

  • Placenta:
    • Maturity of villi (2nd or 3rd trimester).
    • Infarction?
      • Subchorionic less important than maternal aspect.
      • Peripheral aspect of placental disc less important than central region of disc.
    • Blood vessels.
      • Maternal.
      • Fetal.
  • Membranes.
    • Membranitis?
    • Chorioamnionitis?
  • Cord:
    • 3 vessel?
    • Vasculitis/inflammation?

Mnemonic: chorio, cord, vessels, villi (maturity, infarction).

Cord pathology

  • Two vessel cord.
  • Hypercoiling/Hypocoiling.
  • Abnormal insertion.
  • Cord knots (true vs. false).
  • Strictures.
  • Hematoma.
  • Hemangioma.
  • Benign cyst.

Two vessel cord

  • AKA single umbilical artery.

Associations

  • Associated with congenital abnormalities, esp. cardiac - key point.[15]
    • Thought to be an acquired defect (as prevalence is lower in early in gestation).
  • May be seen in association of other cord abnormalities (e.g. marginal insertion, velamentous insertion).
  • In apparently well (liveborn) infants it is associated with (occult) renal abnormalities, specifically vesico-ureteric reflux; there is no evidence for other abnormalities.[16]
  • Associated with maternal diabetes.[17]

Image:

Insertion

Marginal insertion

Definition:

  • The umbilical cord is attached to the placental disc at its margin.

Prevalence:

  • Approximately 12% of placentas.[15]

Relevance:

  • None according to WMSP.[15]
    • In theory, the cord, dependent on its relation to the internal os, is at greater risk of injury (leading to vasa previa) and compression (fetal hypoxia). A retrospective study found cord position in relation to the internal os is predictive for vasa previa.[19]

Velamentous insertion

Definition:

  • The umbilical cord inserts into the fetal membranes.[15]
    • The vessels are not protected by Wharton's jelly.
      • Wharton's jelly = the connective tissue surrounding the vessels in the cord.

Details:[15]

  • 3/4 of the time the vessel also branch; in the remaining 1/4 the vessels stay together.

Relevance:

  • Increased risk of vasa previa.[19]

Knots

General

  • Prevalence ~1.25%.[20][21]
  • Increase risk of stillbirth; odds ratio 3.93.[20]

Gross

Work-up:[21]

  • Diameter measures and colour on both sides of the knot.
  • Knot should be untied to assess for deformation of Wharton's jelly.
  • Sections from both sides of the knot - to look for thrombi.

Note:

  • False knots (large diameter - focally) are common - they cannot be untied.

Microscopic

Features:

  • +/-Thrombi.
    • Fibrin deposition.
  • +/-Lines of Zahn.

Images:

Coiling

  • Hypo- and hypercoiling are both considered problematic.[15]
    • Normal: 1-3 coils/10 cm.[22]
  • Associated with cord stricture, which is usu. at the fetal end of the cord.[23]

Notes:

  • There is little uniformity in how coiling is assessed in the medical literature - though 10% and 90% are considered the cut-points for normal.[24]
    • What are the 10% and 90% cut-points? They are not given in WMSP. UT access to a journal article[25] that might have it is screwed-up.

Cord hematoma

Features:[23]

  • Rare ~ 1/5500.
  • Mortality ~50% is severe.

Image: Hematoma (flylib.com).[26]

Membranes

  • Squamous metaplasia.
  • Chorioamnionitis - see infection section.

Amnion nodosum

General

  • Associated with (long-standing) oligohydramnios.[27]
  • Should be separated from squamous metaplasia of amnion.

Gross

  • Yellow patch or yellow nodules.
    • Some think they are white.[28]

Image: Amnion nodosum (webpathology.com).

Microscopic

Features:

  • Simple epithelium of amnion replaced by (non-keratinizing) stratified squamous epithelium.

Image: Amnion nodosum (webpathology.com).

Passage of meconium

General

  • Associated with fetal distress.
  • Small amount - at term - is considered to be normal.

Gross

  • Green/green discolourization.

Microscopy

Features:[29]

  • Meconium histiocytes - key feature.
    • Macrophages with brown fine granular pigment.
  • Pseudostratified epithelium (amnion) - low power.
  • Amnion - columnar morphology (normally cuboidal).
  • "Drop-out" of individual amnion cells / loss of individual cells.

Time of meconium passage:[30]

  • <1 h - no staining of membranes.
  • 1-3 h - amnion is stained.
  • >3 h - chorion is stained.

DDx:

  • Hemosiderin-laden macrophages.
    • This is sorted-out with an iron stain -- see below.

Notes:

  • The above time course is disputed - in vitro experiments suggest it is considerably longer.[31]


Images:

Special stains

  • Hemosiderin +ve in hemosiderin-laden macrophages.
  • PAS +ve in meconium-laden macrophages.[32]

Useful to differentiate hemosiderin-laden macrophages and meconium laden macrophages:

  • Hemosiderin stain -- +ve for old blood.
    • Prussian-blue stain = hemosiderin stain.[33]

Notes:

  • PAS-D -- +ve in meconium... though may rarely stain hemosiderin.
  • Meconium contains bile.[34]

Squamous metaplasia

  • Benign common finding - no clinical significance.[35]
  • Needs to be separated from amnion nodosum.[36]

Image:

Twin placentas

These are often submitted... even if they are normal. In these specimens, usually, the chorion is the key.

It covers:

  • Monozygotic vs. dizygotic twins.
  • Twin-to-twin transfusion syndrome.

Diseases of the placental attachment

Placenta acreta/percreta/increta

Placenta attaches to the uterus deeper than it should.

Placental abruption

General

Classic clinical manifestations:[38]

  • Vaginal bleeding (~70%).
  • Abdominal pain (~50%).
  • Fetal heart rate abnormalities (~70%).

Sign-out:

  • Pathologists should sign-out this as "focal adherent retroplacental hematoma".
    • The pathologic findings may be due to abruption or manual removal of the placenta.

Gross

Features:[39]

  • Large adherent blood clot.
  • Disc depression on maternal side.

Notes:

  • Loosely attached clot less convincing.
  • Central haemorrhage is the most worrisome.

Microscopic

Features:

  1. Decidual hemorrhage.
    • Blood in the decidua.
  2. Intravillous hemorrhage, AKA villous stromal hemorrhage.
    • "Bags of blood" - blood outside of vessels in the villi.
      • Should not be confused with congested villi.

Notes:

  • There are no definitive microscopic findings for placental abruption.
  • Intravillous hemorrhage is non-specific - may arise in the following: early placental infarct, cord compression, abdominal trauma.

Inflammatory pathologies

Infection

General:[40]

  • Infection usually ascending, i.e. from vagina up through cervix.
    • Associated with intercourse.
  • Hematogenous rare - manifest as villitis.
    • Think TORCH infections (toxoplasmosis, others (syphilis, TB, listeriosis), rubella, cytomegalovirus, herpes simplex virus).
  • Funisitis usually follows chorioamnionitis.
    • Inflammatory cells in umbilical cord are fetal (trivia).

Types (by site)[40]

  • Fetal membranes: chorioamnionitis, membranitis.[41]
  • Umbilical cord: funisitis.
  • Placenta: placentitis, villitis.

Grading infection (chorioamnionitis, membranitis, funisitis)

Membranitis:[41]

  1. PMNs - decidua only.
  2. PMNs - in subamniotic tissue.
  3. 1 or 2 + necrosis in decidua or chorion/subamniotic tissue.

Chorioamnionitis:[41]

  1. placental chorionic plate only.
  2. 1 + subamniotic tissue.
  3. 1 or 2 + necrosis or abscess.

Sternberg separates vasculitis and funisitis without really explaining the terms[41] -- I presume: vasculitis = inflammation of vessels in the umbilical cord. funisitis = inflammation of the cord (vessels and Wharton jelly).

Umbilical cord vasculitis:[41]

  • +0.5 for each vessel.
  • +0.5 for each vessel with severe involvement.

Umbilical funisitis:[41]

  1. Focal inflammation.
  2. Diffuse inflammation.
  3. Necrosis - in vessels or Wharton jelly.

Note: There is no such thing as chorionitis.[42]

Villitis of unknown etiology

  • Abbreviated VUE.

General

Features:[43]

  • Usually term placenta.
  • Prevalence: 5% to 15% of all placentas.
  • Associated with:
    • Intrauterine growth restriction.
    • Recurrent reproductive loss/adverse outcomes in subsequent pregnancies -- key point.
      • Recurrence in up 37% of cases.[44]

Etiology:

  • Unknown - as the name of the entity suggests.
    • Suspected to be immune-mediated.

Microscopic

Features:[43]

  • Lymphocytes in villous stroma - key feature.
    • Usually focal/patchy.
    • Lymphocytes: maternal derivation, T-lymphocytes -- mostly CD8-positive.
  • +/-Intervillositis (lymphocytes between villi).
  • +/-Histiocytes.
  • No plasma cells - this suggests an infectious etiology.[45]
    • Plasma cells may be seen in the decidua -- these can be ignored.

Notes:

  • Neutrophils are usually absent. A significant number of 'em is suggestive of an infectious villitis.
  • Infective villitis is usu. B-cell predominant.

Images:

Infarction

True infarcts

General

  • Associated with retroplacental hematoma.

Gross

Features:[23]

  • Early - red.
  • Late - white/grey.

Images:

Microscopic

Features:

  1. Necrosis of villi; hyaline material (acellular eosinophilic material) replaces the stroma of the villi.
  2. Loss of intervillous space.[23]
    • Villi appear to be crowded.[48]
      • Normal spacing is ~1x smallest villus or larger.
        • In perivillous fibrin deposition - spacing usu. larger than normal.
  3. Prominent syncytial knots.
  4. Thickened trophoblastic basement membrane (below cytotrophoblasts).
  5. +/-Changes seen in decidual vasculopathy:

Images:

Significant infarcts

  • > 3cm --or-- central location --or-- in 1st or 2nd trimester.
    • Small foci are accepted in term placentae - typically at periphery.

Perivillous fibrin deposition

  • Massive perivillous fibrin deposition is assoc. with anti-phospholipid antibody (APLA) syndrome.[50]
    • APLA is assoc. with recurrent miscarriage - can be treated with heparin + ASA.[50]
  • Thought to be an immunologic problem - resulting in platelet activation and fibrin deposition.[50]

Gross

  • Pale (white).
  • Firm.
  • White fibrous sepatae.

Microscopy

Features:

  • Acellular eosinophilic material around formed villi.
  • Obliteration of intervillous space.
    • Intervillous distance increased vis-a-vis normal - key feature.

Notes:

  • Nuclei of villi are usu. preserved.
  • Villi may have secondary infarction, i.e. there may be nuclear destruction (karyolysis, karyorrhexis, pyknosis).

Fetal disease

Fetal thrombotic vasculopathy

General

  • May cause IUGR.
  • Associated with cerebral palsy and common in perinatal deaths.[51]

Microscopic

Features:

  • Thrombus in the fetal vasculature +/- recanalization.
    • Eosinophilic (light pink on H&E), moderately granular intravascular material (fibrin) with layering.

Images:

Hemorrhagic endovasculitis

  • Abbreviated HEV.

General

  • Associated with stillbirth.[54]

Microscopic

Features:[55]

  • Walls of the (fetal) placental blood vessels (in the villi) are disrupted.
  • +/-Intraluminal necrotic debris.
  • RBC fragmentation.

Maternal disease

Hypertensive changes

General

Associated pathologic changes:[56]

  • Placental infarcts.
  • Increased syncytial knots.
  • Hypovascularity of the villi.
  • Cytotrophoblastic proliferation.
  • Thickening of the trophoblastic basement membrane.

Microscopic

Features:[56]

  • Enlarged endothelial cells - fetal capillaries.
  • Atherosis of the spiral arteries - placental bed (maternal).

Notes:

  • One should look for the changes in the membrane roll, not the maternal surface.[57]

Hypertrophic decidual vasculopathy

General

  • A change seen in hypertension.

Microscopic

Features:[58]

  • Mild or moderate:
    1. Perivascular inflammatory cells.
    2. +/-Vascular thrombosis.
    3. Smooth muscle hypertrophy.
    4. Endothelial hyperplasia.
      • Above two lead to narrowing of the decidual spiral arteries[59] -- key feature.
  • Severe:[58]
    1. Atherosis of maternal blood vessels.
      • Foamy macrophages within vascular wall.
    2. Fibrinoid necrosis of vessel wall (amorphous eosinophilic material vessel wall).

General:

  • Seen in intrauterine growth restriction (IUGR).

Images:

HELLP syndrome

General

  • Diagnosed clinically.
  • Pathologically not the same as severe preclampsia.[60]

Definition:

  • H = hemolysis.
  • EL = elevated liver enzymes.
  • LP = low platelets.

Microscopic

Features:[61]

  • Thrombotic microangiopathic vasculopathy.
    • In essence: severe hypertrophic decidual vasculopathy. (???)

Tumours

Chorangioma

General

Epidemiology:

  • Often benign.
  • May be association with:
    • Fetal maternal haemorrhage.
    • Hydrops.
    • IUGR.

Gross

  • White lesions.
    • Occasionally red lesions.

Microscopic

Features:

  • Mass of capillaries.

Image:

Chorangiosis

General

  • Should not be confused with chorangioma.
  • Rare.

Associations:

  • Maternal hypoxia:
    • Smoking.
    • Altitude.
    • Diabetes.

Microscopic

Features:

  • Increased blood vessels in the terminal villi.
  • Not well circumscribed.

Notes:

  • Usually not seen on gross pathology.

See also

References

  1. Yetter JF (March 1998). "Examination of the placenta". Am Fam Physician 57 (5): 1045–54. PMID 9518951.
  2. Hargitai B, Marton T, Cox PM (August 2004). "Best practice no 178. Examination of the human placenta". J. Clin. Pathol. 57 (8): 785–92. doi:10.1136/jcp.2003.014217. PMC 1770400. PMID 15280396. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770400/.
  3. URL: http://smj.sma.org.sg/5012/5012ra1.pdf. Accessed on: 11 February 2011.
  4. CS. 8 February 2011.
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  7. Sternberg, Stephen S. (1997). Histology for Pathologists (2nd ed.). Lippincott Williams & Wilkins. pp. 977. ISBN 978-0397517183.
  8. J Anat. Soc. India 49(2) 149-152 (2000). Available at: http://www.indmedica.com/anatomy/aindex1.cfm?anid=41. Accessed on: January 21, 2009.
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  11. CS. 7 February 2011.
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  16. Srinivasan R, Arora RS (January 2005). "Do well infants born with an isolated single umbilical artery need investigation?". Arch. Dis. Child. 90 (1): 100–1. doi:10.1136/adc.2004.062372. PMC 1720078. PMID 15613529. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1720078/.
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  23. 23.0 23.1 23.2 23.3 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 465. ISBN 978-0781765275.
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  25. PMID 16076615.
  26. URL: http://flylib.com/books/en/2.953.1.49/1/. Accessed on: 10 January 2011.
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