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| ==Oncocytoma of the salivary gland== | | ==Oncocytoma of the salivary gland== |
| *[[AKA]] ''salivary gland oncocytoma''. | | *[[AKA]] ''salivary gland oncocytoma''. |
| ===General===
| | {{Main|Oncocytoma of the salivary gland}} |
| *No risk of malignant transformation.
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| *Rare ~20 reported in literature.<ref>{{cite journal |author=Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T |title=Bilateral oncocytoma in the parotid gland |journal=J Craniofac Surg |volume=23 |issue=3 |pages=e246–7 |year=2012 |month=May |pmid=22627459 |doi=10.1097/SCS.0b013e31824dfccd |url=}}</ref>
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| *Thought to be ~1% of all salivary gland tumours.
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| *Typical age: 60s-80s.
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| *Associated with radiation exposure.
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| *Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref>
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| ===Gross===
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| *Golden brown appearance.
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| ====Image====
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| <gallery>
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| Image:Oncocytoma_of_the_Salivary_Gland.jpg | Salivary gland oncocytoma (WC/euthman)
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| </gallery>
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| ===Microscopic===
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| Features:
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| *Like [[oncocytoma]]s elsewhere.
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| **Eosinophilic cytoplasm (on [[H&E stain]]).
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| ***Due to increased number of mitochrondria.
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| **Fine capillaries.
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| *Architecture: solid sheets, trabeculae or duct-like structure.<ref name=pmid19796983/>
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| Notes:
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| *May have clear cell change.
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| *Multiple small incidental lesions = oncocytosis - ''not'' oncocytoma.
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| DDx:
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| *[[Acinic cell carcinoma]].
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| ====Images====
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| www:
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| *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/figure/Fig1/ Salivary gland oncocytoma (nih.gov)].<ref name=pmid20614263/>
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| <gallery>
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| Image:Parotid_gland_oncocytoma_-_intermed_mag.jpg | Parotid gland oncocytoma - intermed. mag. (WC/Nephron)
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| Image: Parotid gland oncocytoma - high mag.jpg | Parotid gland oncocytoma - high mag. (WC/Nephron)
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| Image:Parotid_gland_oncocytoma_-_very_high_mag.jpg | Parotid gland oncocytoma - very high mag. (WC/Nephron)
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| </gallery>
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| ===IHC===
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| *p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus.
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| =Malignant= | | =Malignant= |