Canalicular adenoma

From Libre Pathology
Jump to: navigation, search
Canalicular adenoma
Diagnosis in short

Canalicular adenoma. H&E stain. (WC)

LM

cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules,

intraluminal squamous balls (common)
Site salivary gland - usually upper lip or buccal mucosa

Signs mass lesion
Prevalence very rare

Canalicular adenoma is a rare salivary gland tumour.

General

  • Exclusively oral cavity.

Clinical:

  • Mass lesion.[1]

Gross

  • Classically upper lip - may be buccal mucosa or palate.

Note:

  • In one large series of 67 cases:[1]
    • Upper lip 69% (47/67).
    • Buccal mucosa 25% (17/67).
    • Palate 6% (4/67).

Microscopic

Features:[1]

  • Cords of tumour ("canals") with beading - characteristic.
  • Cystic spaces/tubules.
  • Intraluminal squamous balls - common (~60% of cases).
  • Myxoid/bluish stroma.

DDx:

Images

www

IHC

Features:[1]

  • S-100 +ve - diffuse and strong.
  • Pankeratin +ve - diffuse and strong.
  • GFAP +ve - luminal.
  • SOX10 +ve - nuclear.
  • p16 +ve - luminal squamous balls.
  • CK5/6 +ve - luminal squamous balls.
  • p63 -ve.
    • Nuclei negative, cytoplasm positive.
    • Positive in basal cell adenoma.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 Thompson, LD.; Bauer, JL.; Chiosea, S.; McHugh, JB.; Seethala, RR.; Miettinen, M.; Müller, S. (Jun 2015). "Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature.". Head Neck Pathol 9 (2): 181-95. doi:10.1007/s12105-014-0560-6. PMID 25141970.