Chronic sialadenitis

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Chronic sialadenitis is a chronic inflammatory process involving a salivary gland.

Chronic sailolithiasis redirects here. Sialadenitis redirects here. Chronic sclerosing sialadenitis (also known as Küttner tumour[1]) redirects here.

General

Etiology:[3]

Associations:

Gross

Features:

  • Typical location: submandibular salivary gland.
  • Salivary gland swelling.[2]

Microscopic

Features:

  • Non-neoplastic mononuclear inflammatory infiltrate (lymphocytes, plasma cells).
  • Fibrosis.
  • +/-Calcifications.

Note:

  • If the infiltrate is predominantly lymphocytes Sjögren's is a possibility, and reporting a Focus score should be considered.

DDx:

Image

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SUBMANDIBULAR GLAND, RIGHT, EXCISION:
- CHRONIC SIALOADENITIS.
- SIALOLITHIASIS.
- TWO BENIGN LYMPH NODES.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show submandibular salivary gland with a mild patchy mixed mononuclear cell infiltrate, fibrosis and a large benign calcification. No zonal necrosis is identified. Significant nuclear atypia is not identified.

Alternate

The sections show a salivary gland with a patchy mixed mononuclear cell infiltrate and fibrosis. Significant nuclear atypia is not identified. Plasma cells are not prominent. Germinal centres are present.

See also

References

  1. Keidar E, Shermetaro J, Kwartowitz G (June 2020). "Pediatric Parotid Chronic Sclerosing Sialadenitis in an African-American Female: A Rare Case and Review of the Literature". Cureus 12 (6): e8846. doi:10.7759/cureus.8846. PMC 7386075. PMID 32754389. //www.ncbi.nlm.nih.gov/pmc/articles/PMC7386075/.
  2. 2.0 2.1 Hasegawa M, Cheng J, Maruyama S, et al. (June 2011). "Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: report of a case and its etiological background". Int J Oral Maxillofac Surg 40 (6): 647–50. doi:10.1016/j.ijom.2010.11.009. PMID 21159490.
  3. URL: http://emedicine.medscape.com/article/882358-overviewhttp://emedicine.medscape.com/article/882358-overview. Accessed on: 10 January 2011.
  4. Eliasson L, Heyden G, Landahl S, Steen B (March 1991). "Effects of tobacco and diuretics on human palatal salivary glands". J. Oral Pathol. Med. 20 (3): 126–9. PMID 2037973.
  5. Beasley, MJ. (Apr 2012). "Lymphoma of the Thyroid and Head and Neck.". Clin Oncol (R Coll Radiol). doi:10.1016/j.clon.2012.02.010. PMID 22475637.
  6. Thompson LDR (November 2019). "IgG4-Related Sialadenitis". Ear Nose Throat J: 145561319890153. doi:10.1177/0145561319890153. PMID 31760789.