Adenoid cystic carcinoma of the breast

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Adenoid cystic carcinoma of the breast
Diagnosis in short

Adenoid cystic carcinoma of the breast. H&E stain.
LM DDx cribriform DCIS, invasive cribriform carcinoma of the breast, collagenous spherulosis
Grossing notes breast grossing
Staging breast cancer staging
Site breast - see invasive breast cancer

Prevalence very rare
Prognosis good
Treatment surgery

Adenoid cystic carcinoma of the breast is a rare type of breast cancer that is similar to a relatively common tumour of the salivary gland.

It is also known as breast adenoid cystic carcinoma, abbreviated BACC.[1]

General

Microscopic

See: Adenoid cystic carcinoma article.

DDx:

Images

www:

IHC

  • One of the 'good prognosis' triple negative breast cancers - ER, PR and HER2 negative.[3]
  • Basal-like breast cancer - p63 and CK5/6 positive.[3]

CD117 positive[3]

Other Resources

Pathology Outlines [1]

See also

References

  1. Crisi, GM.; Marconi, SA.; Makari-Judson, G.; Goulart, RA. (Nov 2005). "Expression of c-kit in adenoid cystic carcinoma of the breast.". Am J Clin Pathol 124 (5): 733-9. doi:10.1309/61MV-ENEK-5EJ7-JKGF. PMID 16203286.
  2. 2.0 2.1 Boujelbene, N.; Khabir, A.; Boujelbene, N.; Jeanneret Sozzi, W.; Mirimanoff, RO.; Khanfir, K. (Dec 2011). "Clinical review - Breast adenoid cystic carcinoma.". Breast. doi:10.1016/j.breast.2011.11.006. PMID 22154460.
  3. 3.0 3.1 3.2 Azoulay, S.; Laé, M.; Fréneaux, P.; Merle, S.; Al Ghuzlan, A.; Chnecker, C.; Rosty, C.; Klijanienko, J. et al. (Dec 2005). "KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome.". Mod Pathol 18 (12): 1623-31. doi:10.1038/modpathol.3800483. PMID 16258515.