Myoepithelioma

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Myoepithelioma is a tumour of the head and neck.

General

  • Usually benign.
    • May be malignant.[1]

Location - head and neck:[2]

  • Parotid gland ~50%.
  • Palate ~25%
  • Submandibular gland ~12%.

Notes:

  • First described in 1972.[3]
  • May be seen in the skin.[4]

Microsopic

Features:[5]

  • Myoepithelial cells - may be:
    • Spindled.
    • Plasmacytoid.
    • Epithelioid.
    • Clear (rare).
  • Lack tubules, i.e. epithelial component.
    • May be up to 10% (or 5%[6]).

DDx:

Images

IHC

Features:[5]

  • S100 +ve.
  • GFAP +ve.
  • CK14 +ve.

Others:[7]

  • SMA +ve.
  • Calponin +ve.

See also

References

  1. Nagao, T.; Sugano, I.; Ishida, Y.; Tajima, Y.; Matsuzaki, O.; Konno, A.; Kondo, Y.; Nagao, K. (Oct 1998). "Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases.". Cancer 83 (7): 1292-9. PMID 9762928.
  2. Barnes, L.; Appel, BN.; Perez, H.; El-Attar, AM. (Jan 1985). "Myoepithelioma of the head and neck: case report and review.". J Surg Oncol 28 (1): 21-8. PMID 2982059.
  3. Saksela, E.; Tarkkanen, J.; Wartiovaara, J. (Sep 1972). "Parotid clear-cell adenoma of possible myoepithelial origin.". Cancer 30 (3): 742-8. PMID 5075358.
  4. Kutzner, H.; Mentzel, T.; Kaddu, S.; Soares, LM.; Sangueza, OP.; Requena, L. (Mar 2001). "Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells.". Am J Surg Pathol 25 (3): 348-55. PMID 11224605.
  5. 5.0 5.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 130. ISBN 978-0470519035.
  6. I. Weinreb. 24 October 2011.
  7. Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 18. ISBN 978-0470519035.