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Difference between revisions of "Ovarian tumours"
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→Serous tumours: +ovarian serous ca
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(→Serous tumours: +ovarian serous ca) |
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==Serous tumours== | ==Serous tumours - overview== | ||
===General=== | ===General=== | ||
*Most common malignant ovarian tumour. | *Most common malignant ovarian tumour. | ||
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*In ''serous borderline tumours'', ''micropapillae'' are thought to have significance -- assoc. with increased risk of distant recurrence<ref>LAE. 19 February 2009.</ref><ref name=pmid15897738>URL: [http://www.ncbi.nlm.nih.gov/pubmed/15897738 http://www.ncbi.nlm.nih.gov/pubmed/15897738]. Accessed on: 7 April 2011.</ref><ref>{{cite journal |author=Piura B, Rabinovich A, Yanai-Inbar I |title=Micropapillary serous carcinoma of the ovary: case report and review of literature |journal=Eur. J. Gynaecol. Oncol. |volume=21 |issue=4 |pages=374–6 |year=2000 |pmid=11055486 |doi= |url=}}</ref> - though is disputed.<ref>{{cite journal |author=Prat J, De Nictolis M |title=Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion |journal=Am. J. Surg. Pathol. |volume=26 |issue=9 |pages=1111-28 |year=2002 |month=September |pmid=12218568 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=26&issue=9&spage=1111}}</ref> | *In ''serous borderline tumours'', ''micropapillae'' are thought to have significance -- assoc. with increased risk of distant recurrence<ref>LAE. 19 February 2009.</ref><ref name=pmid15897738>URL: [http://www.ncbi.nlm.nih.gov/pubmed/15897738 http://www.ncbi.nlm.nih.gov/pubmed/15897738]. Accessed on: 7 April 2011.</ref><ref>{{cite journal |author=Piura B, Rabinovich A, Yanai-Inbar I |title=Micropapillary serous carcinoma of the ovary: case report and review of literature |journal=Eur. J. Gynaecol. Oncol. |volume=21 |issue=4 |pages=374–6 |year=2000 |pmid=11055486 |doi= |url=}}</ref> - though is disputed.<ref>{{cite journal |author=Prat J, De Nictolis M |title=Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion |journal=Am. J. Surg. Pathol. |volume=26 |issue=9 |pages=1111-28 |year=2002 |month=September |pmid=12218568 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=26&issue=9&spage=1111}}</ref> | ||
*Psammoma bodies may be seen in [[endosalpingiosis]].<ref name=pmid1774734>{{cite journal |author=Hallman KB, Nahhas WA, Connelly PJ |title=Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report |journal=J Reprod Med |volume=36 |issue=9 |pages=675–8 |year=1991 |month=September |pmid=1774734 |doi= |url=}}</ref> | *Psammoma bodies may be seen in [[endosalpingiosis]].<ref name=pmid1774734>{{cite journal |author=Hallman KB, Nahhas WA, Connelly PJ |title=Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report |journal=J Reprod Med |volume=36 |issue=9 |pages=675–8 |year=1991 |month=September |pmid=1774734 |doi= |url=}}</ref> | ||
==Serous carcinoma of the ovary== | |||
*[[AKA]] ''ovarian serous carcinoma''. | |||
===General=== | |||
*Most common malignant ovarian tumour in the eldery. | |||
===Microscopic=== | |||
Features: | |||
*Marked nuclear pleomorphism: | |||
**Variation in size - usually marked. | |||
**Variation in staining. | |||
**Variation in shape. | |||
*Prominent nucleolus - '''key feature'''. | |||
*Eccentric nucleus. | |||
*Architecture: | |||
**Solid. | |||
**Papillary - classic. | |||
**Glandular - uncommon. | |||
*+/-Psammoma bodies - uncommon. | |||
*+/-Necrosis - often extensive. | |||
DDx: | |||
*[[Clear cell carcinoma of the ovary]] - less nuclear size variation. | |||
*[[Endometrioid carcinoma of the ovary]] - usu. lower grade. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Serous_carcinoma_cytology.jpg Serous carcinoma - cytology (WC)]. | |||
===IHC=== | |||
*CK7 +ve. | |||
*WT-1 +ve. | |||
*CA-125 +ve. | |||
*ER +ve.<ref name=pmid21164285>{{Cite journal | last1 = DeLair | first1 = D. | last2 = Oliva | first2 = E. | last3 = Köbel | first3 = M. | last4 = Macias | first4 = A. | last5 = Gilks | first5 = CB. | last6 = Soslow | first6 = RA. | title = Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 1 | pages = 36-44 | month = Jan | year = 2011 | doi = 10.1097/PAS.0b013e3181ff400e | PMID = 21164285 }}</ref> | |||
Others: | |||
*HNF-1beta -ve.<ref>{{Cite journal | last1 = Tsuchiya | first1 = A. | last2 = Sakamoto | first2 = M. | last3 = Yasuda | first3 = J. | last4 = Chuma | first4 = M. | last5 = Ohta | first5 = T. | last6 = Ohki | first6 = M. | last7 = Yasugi | first7 = T. | last8 = Taketani | first8 = Y. | last9 = Hirohashi | first9 = S. | title = Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. | journal = Am J Pathol | volume = 163 | issue = 6 | pages = 2503-12 | month = Dec | year = 2003 | doi = | PMID = 14633622 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed }}</ref><ref name=omim189907>{{OMIM|189907}}</ref> | |||
**Usually +ve in [[clear cell carcinoma of the ovary]]. | |||
==Serous cystadenoma of the ovary== | ==Serous cystadenoma of the ovary== | ||