Thecoma

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Thecoma
Diagnosis in short

Thecoma. H&E stain.

LM bland oval or spindled nuclei, abundant cytoplasm that is pale and vaculolated
LM DDx ovarian fibroma, fibroma-thecoma
IHC alpha-inhibin +ve
Gross solid yellow mass, usually well-circumscribed
Site ovary - see ovarian tumours

Prevalence uncommon
Prognosis benign
Clin. DDx other ovarian tumours

Thecoma is an ovarian sex-cord stromal tumour.

General

  • Associated with compression & atrophy of ovarian cortex, thought to arise from medulla.[1]
  • Approximately 50% have symptoms related to estrogen secretion.[2]
    • May also be viralizing.

Gross

Features:

  • Solid yellow mass, usually well-circumscribed.[3]

DDx:

Microscopic

Features:[2]

  • Nuclei with oval to spindle morphology.
  • Abundant cytoplasm that is pale, vaculolated -- key feature.

DDx:

Images

IHC

  • Alpha-inhibin +ve (90%+).[2]

See also

References

  1. Nocito, AL.; Sarancone, S.; Bacchi, C.; Tellez, T. (Feb 2008). "Ovarian thecoma: clinicopathological analysis of 50 cases.". Ann Diagn Pathol 12 (1): 12-6. doi:10.1016/j.anndiagpath.2007.01.011. PMID 18164409.
  2. 2.0 2.1 2.2 Roth, LM. (Jul 2006). "Recent advances in the pathology and classification of ovarian sex cord-stromal tumors.". Int J Gynecol Pathol 25 (3): 199-215. doi:10.1097/01.pgp.0000192271.22289.e6. PMID 16810055.
  3. 3.0 3.1 Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 398. ISBN 978-0521868792.