Ovarian fibroma

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Ovarian fibroma
Diagnosis in short

Ovarian fibroma. H&E stain.

LM

spindle cells with a central nucleus and no nuclear atypia;

patternless pattern (not fascicular, not herring bone), +/-calcification
LM DDx thecoma, leiomyoma, fibrosarcoma, metastatic metaplastic carcinoma, endometriosis with fibrosis
IHC inhibin -ve
Gross solid white mass, usu. well-circumscribed
Site ovary - see ovarian tumours

Syndromes Meigs syndrome, nevoid basal cell carcinoma syndrome (esp. if calcified)

Prevalence uncommon
Prognosis benign
Clin. DDx other ovarian tumours - esp. solid ones

Ovarian fibroma is a benign ovarian tumour.

General

Gross

Features:

  • Solid white mass, usually well-circumscribed.[4]

Note:

  • Thecoma = yellow solid mass.[4]

Images

www:

Microscopic

Features:[5][6]

  • Spindle cells with central nucleus and no nuclear atypia.
  • Patternless pattern (AKA storiform pattern) - not fascicular, not herring bone.
  • Stainable lipid - minimal or none.[6]

Notes:

  • May be cellular.
  • Mitotic activity minimal.[7]

DDx:

Images

IHC

  • Inhibin -ve (~75%).[6]

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 OVARIAN MASS ("FIBROMA"), LEFT, EXCISION:
- FIBROMA.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show spindle cells in a patternless pattern. There is no appreciable nuclear atypia. No mitotic activity is apparent. No necrosis is identified. No calcifications are seen. A small amount of benign ovarian parenchyma is present at the edge of the lesion.

See also

References

  1. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1103. ISBN 0-7216-0187-1.
  2. Tytle, T.; Rosin, D. (Sep 1984). "Bilateral calcified ovarian fibromas.". South Med J 77 (9): 1178-80. PMID 6385289.
  3. URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/353/full.html. Accessed on: 4 October 2011.
  4. 4.0 4.1 Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 398. ISBN 978-0521868792.
  5. URL: http://www.pathologyoutlines.com/ovarytumor.html#fibroma. Accessed on: 7 May 2012.
  6. 6.0 6.1 6.2 Roth, LM. (Jul 2006). "Recent advances in the pathology and classification of ovarian sex cord-stromal tumors.". Int J Gynecol Pathol 25 (3): 199-215. doi:10.1097/01.pgp.0000192271.22289.e6. PMID 16810055.
  7. Huang, L.; Liao, LM.; Wang, HY.; Zheng, M. (2010). "Clinicopathologic characteristics and prognostic factors of ovarian fibrosarcoma: the results of a multi-center retrospective study.". BMC Cancer 10: 585. doi:10.1186/1471-2407-10-585. PMID 20979607.
  8. Rajabi, P.; Hani, M.; Bagheri, M.; Mirzadeh, F. (2014). "Large ovarian leiomyoma in young woman.". Adv Biomed Res 3: 88. doi:10.4103/2277-9175.128001. PMID 24761396.