Gonadoblastoma

Gonadoblastoma
Diagnosis in short
Gondaloblastoma. H&E stain.
LM	immature germ cells (resembling Sertoli cells or granulosa cells),[citation needed] primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
LM DDx	dysgerminoma, sex cord tumour with annular tubules
Site	ovary
Clinical history	abnormal sexual development
Prevalence	very rare

Gonadoblastoma is a rare germ cell tumour with sex cord elements.

General

• Associated with abnormal sexual development.
• Often coexist with a dysgerminoma.
• A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.

Gross

• +/-Cystic.

Microscopic

Features:

• Immature germ cells resembling Sertoli cells or granulosa cells.^{[citation needed]}
  • Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
  • Granulosa cells = form follicle-like structures.
    • May form nests.
• Primitive germ cells resemble those of a dysgerminoma.
  • Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
• +/-Calcification (very common).
• +/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.

DDx:

• Sex cord tumour with annular tubules.
• Dysgerminoma.

Images

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  Gonadoblastoma - very low mag. (WC/Nephron)

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  Gonadoblastoma - low mag. (WC/Nephron)

• 

  Gonadoblastoma - intermed mag. (WC/Nephron)

• 

  Gonadoblastoma - high mag. (WC/Nephron)

• 

  Gonadoblastoma - high mag. (WC/Nephron)

• 

  Gonadoblastoma - very high mag. (WC/Nephron)

www:

• Gonadoblastoma - low mag. (webpathology.com).
• Gonadoblastoma - high mag. (webpathology.com).
• Gonadoblastoma - high mag. (webpathology.com).
• Gonadoblastoma - low mag. (flickr.com).
• Gonadoblastoma - intermed. mag. (flickr.com).
• Gonadoblastoma - high mag. (flickr.com).
• Gonadoblastoma - several cases (upmc.edu).

See also

• Germ cell tumours.