Sertoli cell tumour

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Sertoli cell tumour
Diagnosis in short

Sertoli cell tumour. H&E stain.

LM groups of cells in cords or trabeculae, cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin
LM DDx granulosa cell tumour, epithelioid adenomatoid tumour, sertoli cell nodule, Sertoli-Leydig tumour
IHC alpha-inhibin, calretinin
Site testis, ovary

Syndromes Peutz-Jeghers syndrome, Carney complex

Signs testicular mass
Prevalence uncommon

Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis. It is occasionally seen in women.

General

  • Arises from Sertoli cells (AKA nurse cells).
  • Occasionally seen in women.[1]

May be seen in several syndrome - esp. if there is calcification:

Microscopic

Features:

  • Groups of cells in cords or trabeculae (beam-like arrangement).
  • Cells have:
    • Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
    • Slightly irregular nucleoli.
    • Granular irregular appearing chromatin.

Negatives:

  • Mitoses are rare.
  • No significant nuclear atypia.

DDx:

Images

www:

IHC

  • Alpha-inhibin +ve (~95% of cases[4]).
  • Calretiin +ve (~55% of cases[4]).

Others:

See also

References

  1. Zizi-Sermpetzoglou, A.; Petrakopoulou, N.; Tepelenis, N.; Savvaidou, V.; Manoloudaki, K.; Katsoulis, M. (2010). "Pure Sertoli cell tumor. a case report and review of the literature.". Eur J Gynaecol Oncol 31 (1): 117-9. PMID 20349797.
  2. Libé, R.; Horvath, A.; Vezzosi, D.; Fratticci, A.; Coste, J.; Perlemoine, K.; Ragazzon, B.; Guillaud-Bataille, M. et al. (Jan 2011). "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.". J Clin Endocrinol Metab 96 (1): E208-14. doi:10.1210/jc.2010-1704. PMID 21047926.
  3. Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.
  4. 4.0 4.1 4.2 Zhao, C.; Bratthauer, GL.; Barner, R.; Vang, R. (Sep 2007). "Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.". Am J Surg Pathol 31 (9): 1378-86. doi:10.1097/PAS.0b013e3180339961. PMID 17721194.