Difference between revisions of "Inflammatory skin disorders"

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| -subcorneal<br>-suprabasillar<br>-subepidermal  
| -subcorneal<br>-suprabasillar<br>-subepidermal  
| -[[pemphigus foliaceus]]<br>-[[pemphigus vulgaris]]<br>-[[dermatitis herpetiformis]]
| -[[pemphigus foliaceus]]<br>-[[pemphigus vulgaris]]<br>-[[dermatitis herpetiformis]]
| [http://commons.wikimedia.org/wiki/File:Pemphigus_vulgaris_-_low_mag.jpg (WC)]
| [[Image:Pemphigus_vulgaris_-_low_mag.jpg|thumb|150px|center|[[pemphigus vulgaris|PV]] (WC)]]
|-
|-
| Interface
| [[Interface_dermatitides|Interface]]
| inflammation at DE junction
| inflammation at DE junction
| -vacuolar (minimal)<br>-lichenoid (band-like)  
| -vacuolar (minimal)<br>-lichenoid (band-like)  
| -[[erythema multiforme]], [[SLE]]<br>-[[lichen planus]]  
| -[[erythema multiforme]], [[SLE]]<br>-[[lichen planus]]  
|
| [[Image:Vacuolar interface dermatitis - high mag.jpg|thumb|center|150px|[[vacuolar interface dermatitis|VID]] (WC)]]
|-
|-
| Nodular & diffuse  
| [[Nodular and diffuse dermatitides|Nodular & diffuse]]
| intradermal inflammatory infiltrate - nodular and/or diffuse
| intradermal inflammatory infiltrate - nodular and/or diffuse
| -neutrophic<br>-lymphocytic<br>-plasmic<br>-eosinophilic<br>-histocytic
| -neutrophic<br>-lymphocytic<br>-plasmic<br>-eosinophilic<br>-histocytic
| -follicular occlusion triad, ruptured cyst/follicle<br>-[[CTCL]], reactive<br>-[[plasma cell neoplasm]], [[syphilis]]<br>-eosinophilic cellulitis, [[Kimura disease]]<br>-[[granuloma annulare]], [[sarcoidosis]], [[TB]]  
| -follicular occlusion triad, ruptured cyst/follicle<br>-[[CTCL]], reactive<br>-[[plasma cell neoplasm]], [[syphilis]]<br>-eosinophilic cellulitis, [[Kimura disease]]<br>-[[granuloma annulare]], [[sarcoidosis]], [[TB]]  
| [http://commons.wikimedia.org/wiki/File:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg (WC)]
| [[Image:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg|thumb|center|110px|[[CTCL]] (WC)]]
|-
|-
| Spongiotic
| [[Spongiotic_dermatitides|Spongiotic]]
| small empty spaces between keratinocytes - can see squamous bridges (best seen at high power); +/- quasi-microvacuolar appearance
| small empty spaces between keratinocytes - can see squamous bridges (best seen at high power); +/- quasi-microvacuolar appearance
| -acute<br>-subacute<br>-chronic
| -acute<br>-subacute<br>-chronic
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| -small vessel <br> -medium vessel <br> -large vessel
| -small vessel <br> -medium vessel <br> -large vessel
| -[[leukocytoclastic vasculitis]]<br>-[[PAN]]<br>-[[giant cell arteritis]]
| -[[leukocytoclastic vasculitis]]<br>-[[PAN]]<br>-[[giant cell arteritis]]
| [http://commons.wikimedia.org/wiki/File:Churg-Strauss_syndrome_-_high_mag.jpg (WC)]
| [[Image:Churg-Strauss_syndrome_-_high_mag.jpg |thumb|150px|[[Eosinophilic granulomatosis with polyangiitis|EGPA]] (WC)]]
|-
|-
| Perivascular
| [[Dermatitides_with_perivascular_inflammation|Perivascular]]
| inflammation around vessels
| inflammation around vessels
| -neutrophilic<br>-lymphocytic<br>-mastocytic<br>-eosinophilic
| -neutrophilic<br>-lymphocytic<br>-mastocytic<br>-eosinophilic
| -[[cellulitis]]<br>-viral exanthem, Rx reaction<br>-[[mastocytosis]]<br>-insect bite, Rx reaction  
| -[[cellulitis]]<br>-viral exanthem, Rx reaction<br>-[[mastocytosis]]<br>-insect bite, Rx reaction  
| [http://commons.wikimedia.org/wiki/File:Dermal_perivascular_lymphoeosinophilic_infiltrate_-_high_mag.jpg (WC)]
| [[Image:Dermal_perivascular_lymphoeosinophilic_infiltrate_-_high_mag.jpg |thumb|center|110px|DPLI (WC)]]
|-
|-
| [[Panniculitis]]
| [[Panniculitis]]
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|
|
|-
|-
| Psoriasiform
| [[Psoriasiform dermatitides|Psoriasiform]]
| epidermal thickening<br>and long rete ridges  
| epidermal thickening<br>and long rete ridges  
| -regular<br>-irregular
| -regular<br>-irregular
| -[[psoriasis]]<br>-[[lichen simplex chronicus]]
| -[[psoriasis]]<br>-[[lichen simplex chronicus]]
| [http://commons.wikimedia.org/wiki/File:Lichen_simplex_chronicus_-_very_low_mag.jpg (WC)]
| [[Image:Lichen_simplex_chronicus_-_very_low_mag.jpg|thumb|150px|center|[[Lichen simplex chronicus|LSC]] (WC)]]
|}
|}
Notes:  
Notes:  
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*Psoriatic arthritis.
*Psoriatic arthritis.
*Drug-induced.
*Drug-induced.
*Dermatophytosis (fungal infection).
*[[Dermatomycosis]] (fungal infection).
*Others.
*Others.


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===Microscopic===
===Microscopic===
Features:<ref>{{Ref PBoD8|1191}}</ref>
Features:<ref>{{Ref PBoD8|1191}}</ref>
*Spongiosis (epidermal edema).
*[[Spongiosis]] (epidermal edema).
*Acanthosis (epidermal thickening).
*Acanthosis (epidermal thickening).
*"Follicular lipping" = parakeratosis with neutrophils.
*"Follicular lipping" = parakeratosis with neutrophils.
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===General===
===General===
*A group of skin diseases - includes:
*A group of skin diseases - includes:
**The systemic disease, [[systemic lupus erythematosus]], that typically has multi-organ involvement.
**The systemic disease, [[systemic lupus erythematosus]], that typically has multi-organ involvement.
 
SLE has a variety of skin manifestations:
*[[Panniculitis]].
*Vacuolar interface dermatitis.
*Bullae ([[bullous disease|bullous]] systemic lupus erythematosus).
*Deep and superficial dermal, lymphocyte predominant, inflammation.  


===Microscopic===
===Microscopic===
Features - classic:
Features - classic:
*Lymphocytic interface dermatitis.<ref>JAH. 20 February 2009.</ref>
*Lymphocytic interface dermatitis.<ref>JAH. 20 February 2009.</ref>
*Basal layer vacuolation.<ref name=pmid18384217>{{cite journal |author=Crowson AN, Magro CM, Mihm MC |title=Interface dermatitis |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=4 |pages=652–66 |year=2008 |month=April |pmid=18384217 |doi= |url=http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282008%29132%5B652%3AID%5D2.0.CO%3B2}}</ref>
*Basal layer vacuolization.<ref name=pmid18384217>{{cite journal |author=Crowson AN, Magro CM, Mihm MC |title=Interface dermatitis |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=4 |pages=652–66 |year=2008 |month=April |pmid=18384217 |doi= |url=http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282008%29132%5B652%3AID%5D2.0.CO%3B2}}</ref>
*Intradermal mucin.
*Intradermal mucin.
*Thin epidermis.
*Thin epidermis.
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*[[Discoid lupus erythematosus]].
*[[Discoid lupus erythematosus]].
*Drug reaction (drug-induced lupus erythematosus).
*Drug reaction (drug-induced lupus erythematosus).
*[[Solar elastosis]] - may be confused with ''mucin''; vacuolar interface dermatitis ''not'' present


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Vacuolar_interface_dermatitis_-_intermed_mag.jpg Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)].
Image:Vacuolar_interface_dermatitis_-_low_mag.jpg | Vacuolar interface dermatitis with dermal mucin - low mag. (WC)
**[http://commons.wikimedia.org/wiki/File:Vacuolar_interface_dermatitis_-_high_mag.jpg Vacuolar interface dermatitis with dermal mucin - high mag. (WC)].
Image:Vacuolar_interface_dermatitis_-_intermed_mag.jpg | Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)
Image:Vacuolar_interface_dermatitis_-_high_mag.jpg | Vacuolar interface dermatitis with dermal mucin - high mag. (WC)
Image:Vacuolar_interface_dermatitis_-_very_high_mag.jpg | Vacuolar interface dermatitis with dermal mucin - very high mag. (WC)
</gallery>


==Discoid lupus erythematosus==
==Discoid lupus erythematosus==
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==Lichen planus==
==Lichen planus==
:''Should '''not''' be confused with [[lichen planus-like keratosis]]''.
*Abbreviated ''LP''.
===General===
===General===
*An oral pathology.
*An [[oral pathology]] - classically.
*May be seen where the sun don't shine - [[penis]],<ref name=pmid20082512>{{Cite journal  | last1 = Teichman | first1 = JM. | last2 = Sea | first2 = J. | last3 = Thompson | first3 = IM. | last4 = Elston | first4 = DM. | title = Noninfectious penile lesions. | journal = Am Fam Physician | volume = 81 | issue = 2 | pages = 167-74 | month = Jan | year = 2010 | doi =  | PMID = 20082512 }}</ref> [[vulva]] and [[vagina]].<ref name=pmid20062629>{{Cite journal  | last1 = Gupta | first1 = R. | last2 = Bansal | first2 = B. | last3 = Singh | first3 = S. | last4 = Yadav | first4 = I. | last5 = Gupta | first5 = K. | last6 = Kudesia | first6 = M. | title = Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report. | journal = Cases J | volume = 2 | issue =  | pages = 9306 | month =  | year = 2009 | doi = 10.1186/1757-1626-2-9306 | PMID = 20062629 }}</ref>
*May be seen where the sun don't shine - [[penis]],<ref name=pmid20082512>{{Cite journal  | last1 = Teichman | first1 = JM. | last2 = Sea | first2 = J. | last3 = Thompson | first3 = IM. | last4 = Elston | first4 = DM. | title = Noninfectious penile lesions. | journal = Am Fam Physician | volume = 81 | issue = 2 | pages = 167-74 | month = Jan | year = 2010 | doi =  | PMID = 20082512 }}</ref> [[vulva]] and [[vagina]].<ref name=pmid20062629>{{Cite journal  | last1 = Gupta | first1 = R. | last2 = Bansal | first2 = B. | last3 = Singh | first3 = S. | last4 = Yadav | first4 = I. | last5 = Gupta | first5 = K. | last6 = Kudesia | first6 = M. | title = Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report. | journal = Cases J | volume = 2 | issue =  | pages = 9306 | month =  | year = 2009 | doi = 10.1186/1757-1626-2-9306 | PMID = 20062629 }}</ref>


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*6 Ps: pruritic (itchy), purple, polygonal, planar papules and plaques.
*6 Ps: pruritic (itchy), purple, polygonal, planar papules and plaques.


Note:
*Clinically, lichen planus and [[lichen sclerosus]] are similar. The main difference is lichen planus involves mucous membranes.<ref name=pmid20868406>{{Cite journal  | last1 = McPherson | first1 = T. | last2 = Cooper | first2 = S. | title = Vulval lichen sclerosus and lichen planus. | journal = Dermatol Ther | volume = 23 | issue = 5 | pages = 523-32 | month =  | year =  | doi = 10.1111/j.1529-8019.2010.01355.x | PMID = 20868406 }}</ref>
===Gross===
===Gross===
*Wickham striae = white lines/dots.
*Wickham striae = white lines/dots.
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*Hyperkeratosis; stratum corneum thickened.
*Hyperkeratosis; stratum corneum thickened.
*Necrotic basal cell in dermis = colloid bodies = Civatte bodies.<ref name=Ref_PCPBoD8_604>{{Ref PCPBoD8|604}}</ref>
*Necrotic basal cell in dermis = colloid bodies = Civatte bodies.<ref name=Ref_PCPBoD8_604>{{Ref PCPBoD8|604}}</ref>
**Pink bodies approximately the size of a keratinocyte.
Notes:
*Hyperkeratosis and hypergranulosis are not seen in [[erythema multiforme]].
*Colloid bodies = cytoid bodies = Civatte bodies = hyaline bodies = apoptotic bodies.<ref>URL: [http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html]. Accessed on: 28 August 2011.</ref>
**DDx: [[systemic lupus erythematosus]], [[lichen planus]], and [[graft-versus-host disease]].


DDx:
DDx:
*[[Bullous disease]], subepithelial vesicular.
*[[Bullous disease]], subepithelial vesicular.
*[[Lichenoid keratosis]] (lichen planus-like keratosis) - parakeratosis prominent, no oral mucosal involvement.  
*[[Lichenoid keratosis]] (lichen planus-like keratosis) - parakeratosis prominent, no oral mucosal involvement.  
*Fungal infection.<ref name=Ref_Derm36>{{Ref Derm|36}}</ref>
*Lichenoid drug reaction - unusual body site affected, separated clinically.
*Lichenoid [[actinic keratosis]] - basal atypia, [[solar elastosis]].
====Images====
<gallery>
Image:Lichen_planus_intermed_mag.jpg | Lichen planus - intermed. mag. (WC/Nephron)
Image:Lichen_planus_low_mag.jpg | Lichen planus - low mag. (WC/Nephron)
</gallery>
===Stains===
*PAS-D or PAS-F to exclude a fungal infection.
===Sign out===
<pre>
FORESKIN, CIRCUMCISION:
- LICHEN PLANUS.
</pre>


Notes:
<pre>
*Hyperkeratosis and hypergranulosis are not seen in [[erythema multiforme]].
VULVA, LEFT POSTERIOR FOURCHETTE, BIOPSY:
*Colloid bodies = cytoid bodies = Civatte bodies = hyaline bodies = apoptotic bodies.<ref>URL: [http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html]. Accessed on: 28 August 2011.</ref>
- COMPATIBLE WITH LICHEN PLANUS.
**DDx: [[systemic lupus erythematosus]], [[lichen planus]], and [[graft-versus-host disease]].
</pre>
 
====Micro====
The sections show skin with a lymphoplasmacytic interface dermatitis, basal cell loss, hypergranulosis, hyperkeratosis, loss of the rete ridges and Civatte bodies.
 
The epidermis matures to the surface. No significant nuclear atypia is identified.


Images:
Fungal organisms are not identified with a PAS-D stain.
*[http://commons.wikimedia.org/wiki/File:Lichen_planus_intermed_mag.jpg Lichen planus - intermed. mag. (WC)]
*[http://commons.wikimedia.org/wiki/File:Lichen_planus_low_mag.jpg Lichen planus - low mag. (WC)].


==Lichen sclerosus==  
==Lichen sclerosus==  
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*Other considerations:
*Other considerations:
**Drug-induced psoriasis.<ref>{{Cite journal  | last1 = Milavec-Puretić | first1 = V. | last2 = Mance | first2 = M. | last3 = Ceović | first3 = R. | last4 = Lipozenčić | first4 = J. | title = Drug induced psoriasis. | journal = Acta Dermatovenerol Croat | volume = 19 | issue = 1 | pages = 39-42 | month = Mar | year = 2011 | doi =  | PMID = 21489366 }}</ref>
**Drug-induced psoriasis.<ref name=pmid21489366>{{Cite journal  | last1 = Milavec-Puretić | first1 = V. | last2 = Mance | first2 = M. | last3 = Ceović | first3 = R. | last4 = Lipozenčić | first4 = J. | title = Drug induced psoriasis. | journal = Acta Dermatovenerol Croat | volume = 19 | issue = 1 | pages = 39-42 | month = Mar | year = 2011 | doi =  | PMID = 21489366 }}</ref>


Clinical:
====Clinical====
*''Auspitz sign'' = pin-point bleeding on removal of scale.
*''Auspitz sign'' = pin-point bleeding on removal of scale.
*''Koebner phenomenon'' = lesions form at site of trauma.
*''Koebner phenomenon'' = lesions form at site of trauma.
*Common locations: knees, elbows, scalp, glands penis.<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8|603}}</ref>
 
Common locations:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8|603}}</ref>  
*Knees, elbows, scalp, glans [[penis]].
 
===Microscopic===
===Microscopic===
Features:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8|603}}</ref>
Features:<ref name=Ref_PCPBoD8_603>{{Ref PCPBoD8|603}}</ref>
*Acanthosis + long rete ridges (psoriasiform hyperplasia).
*"Regular" acanthosis + long rete ridges (psoriasiform hyperplasia).
**"Regular" ([[Psoriasiform dermatitides|psoriasiform change]]) = rete ridges are of similar length and thickness.
*Parakeratosis.
*Parakeratosis.
*Dilated vessels in superficial dermis (give rise to ''Auspitz sign'').
*Dilated vessels in superficial dermis (give rise to ''Auspitz sign'').
*Spongiform pustules = PMNs in stratum spinosum.
*Spongiform pustules = [[PMN]]s in stratum spinosum.
*PMNs in parakeratotic stratum corneum (Munro microabscess).
*PMNs in parakeratotic stratum corneum (Munro microabscess).
*Thinning of the suprapapillary plate.
*Thinning of the suprapapillary plate.
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DDx:
DDx:
*Dermatophytosis ([[Fungi|fungal infection]]).
*[[Dermatomycosis]] ([[Fungi|fungal infection]]).
*Drug reaction.
*Drug reaction.
Note:
*[[Dermatophytosis]] = ring worm; dermatophystosis != [[dermatomycosis]].
====Images====
www:
*[http://missinglink.ucsf.edu/lm/dermatologyglossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/Psoriasis_low_power.jpg Psoriasis - low mag. (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/dermatologyglossary/psoriasis.html http://missinglink.ucsf.edu/lm/dermatologyglossary/psoriasis.html]. Accessed on: 4 September 2013.</ref>
===Stains===
*[[PASD stain]] -ve for [[fungi|fungal]] organisms.
===Sign out===
<pre>
SKIN LESION, LEFT ARM, PUNCH BIOPSY:
- SKIN WITH ACANTHOSIS, HYPERKERATOSIS, FOCAL PARAKERATOSIS, PROMINENT
  DILATED VESSELS IN THE SUPERFICIAL DERMIS, SUPERFICIAL SPONGIFORM PUSTULES.
- MILD NONSPECIFIC PERIVASCULAR INFLAMMATION.
- NEGATIVE FOR FUNGAL ORGANISMS WITH PAS STAINING.
COMMENT:
The findings are compatible with psoriasis. 
</pre>
====Micro====
The sections show skin with regular psoriasiform change, hyperkeratosis, focal parakeratosis, prominent dilated vessels in the superficial dermis, superficial clusters of intraepidermal neutrophils (spongiform pustules) and thinning of the suprapapillary plate is present. A few perivascular inflammatory cells are present.
There is no epidermal necrosis. Eosinophils are not apparent. The lymphocytes do not have significant atypia.


==Lichen striatus==
==Lichen striatus==
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===Microscopic===
===Microscopic===
Features:
Features:<ref name=Ref_Derm198-9>{{Ref Derm|198-9}}</ref>
*Neutrophilic vasculitis - often subtle:
**Neutrophils within blood vessel walls.
**Vessels destruction ([[fibrinoid necrosis]] or nuclear dust).
*Mixed inflammatory superficial dermal infiltrate.
*Mixed inflammatory superficial dermal infiltrate.
**Eosinophils.
**Eosinophils, neutrophils, plasma cells, histiocytes.
**Neutrophils.
**Plasma cells.
**Histiocytes.
*Lesion separated from the (normal) epidermis (Grenz zone).<ref name=dermatlas_gf>URL: [http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=1289066309 http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=1289066309]. Accessed on: 23 September 2011.</ref>
*Lesion separated from the (normal) epidermis (Grenz zone).<ref name=dermatlas_gf>URL: [http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=1289066309 http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=1289066309]. Accessed on: 23 September 2011.</ref>
DDx of chronic fibrosing [[leukocytoclastic vasculitis]]:<ref name=Ref_Derm198-9>{{Ref Derm|198-9}}</ref>
*Granuloma faciale.
*Erythema elevatum diutinum - lacks Grenz zone.
*Inflammatory pseudotumour.


Image:
Image:
Line 319: Line 384:
*[[Spongiotic dermatitides]].
*[[Spongiotic dermatitides]].


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Spongiotic_dermatitis_-_high_mag.jpg Mild spongiotic dermatitis - high mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Spongiotic_dermatitis_-_very_high_mag.jpg Mild spongiotic dermatitis - very high mag. (WC)].
Image:Spongiotic_dermatitis_-_high_mag.jpg | Mild spongiotic dermatitis - high mag. (WC)
Image:Spongiotic_dermatitis_-_very_high_mag.jpg | Mild spongiotic dermatitis - very high mag. (WC)
</gallery>


==Sweet syndrome==
==Sweet syndrome==
Line 333: Line 400:
DDx ''rips'':
DDx ''rips'':
*Rheumatoid neutrophilic dermatitis.
*Rheumatoid neutrophilic dermatitis.
*Bowel-associated dermatosis-arthritis syndrome.
*[[Bowel-associated dermatosis-arthritis syndrome]] (BADAS).
*Pyoderma gangrenosum.
*[[Pyoderma gangrenosum]].
*Sweet syndrome.  
*Sweet syndrome.  


Image:
Image:
*[http://dermatology.cdlib.org/94/NYU/Apr2002/041602-7b.jpg Sweet syndrome (cdlib.org)].<ref>URL: [http://dermatology.cdlib.org/94/NYU/Apr2002/7.html http://dermatology.cdlib.org/94/NYU/Apr2002/7.html]. Accessed on: 4 January 2012.</ref>
*[http://dermatology.cdlib.org/94/NYU/Apr2002/041602-7b.jpg Sweet syndrome (cdlib.org)].<ref>URL: [http://dermatology.cdlib.org/94/NYU/Apr2002/7.html http://dermatology.cdlib.org/94/NYU/Apr2002/7.html]. Accessed on: 4 January 2012.</ref>
==Granuloma inguinale==
:'''Not''' to be confused with ''[[granuloma annulare]]''.
*Previously known as ''donovanosis''.
===General===
*Infection caused by ''Klebsiella granulomatis'' - [[Gram stain|Gram]]-negative, rod-shaped bacteria.
**Used to be known as ''Calymmatobacterium granulomatis''.<ref name=pmid12473810>{{cite journal |author=O'Farrell N |title=Donovanosis |journal=Sex Transm Infect |volume=78 |issue=6 |pages=452–7 |year=2002 |month=December |pmid=12473810 |pmc=1758360 |doi= |url=http://sti.bmj.com/cgi/pmidlookup?view=long&pmid=12473810}}</ref>
Location:
*[[Penis]].
*[[Vulva]].
Clinical:<ref name=pmid21738983>{{Cite journal  | last1 = Bezerra | first1 = SM. | last2 = Jardim | first2 = MM. | last3 = Silva | first3 = VB. | title = Granuloma inguinale (Donovanosis). | journal = An Bras Dermatol | volume = 86 | issue = 3 | pages = 585-6 | month = Jun | year = 2011 | doi =  | PMID = 21738983 |URL = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000300028&lng=en&nrm=iso&tlng=en }}</ref>
*Sexually transmitted.
*Nodule or papule developing into a painless ulcer in the inguinal region.
*No lymphadenopathy (unlike [[syphilis]]).
===Microscopic===
Features:
*Donovan bodies - '''key feature''':
**Rod-shaped bodies within histiocytes.
DDx:
*[[Syphilis]].
Image:
*[http://microblog.me.uk/213 Granuloma inguinale - crappy image (microblog.me.uk)].
===Stains===
*[[Giemsa stain]] - highlights organisms.
==Pyoderma gangrenosum==
{{Main|Pyoderma gangrenosum}}
==Necrobiotic xanthogranuloma==
*Abbreviated ''NXG''.
{{Main|Necrobiotic xanthogranuloma}}


=DDx for pattern=
=DDx for pattern=
Line 344: Line 448:
DDx:<ref name=pmid18418089>{{cite journal |author=Brinster NK |title=Dermatopathology for the surgical pathologist: a pattern based approach to the diagnosis of inflammatory skin disorders (part I) |journal=Adv Anat Pathol |volume=15 |issue=2 |pages=76–96 |year=2008 |month=March |pmid=18418089 |doi=10.1097/PAP.0b013e3181664e8d |url=}}</ref>
DDx:<ref name=pmid18418089>{{cite journal |author=Brinster NK |title=Dermatopathology for the surgical pathologist: a pattern based approach to the diagnosis of inflammatory skin disorders (part I) |journal=Adv Anat Pathol |volume=15 |issue=2 |pages=76–96 |year=2008 |month=March |pmid=18418089 |doi=10.1097/PAP.0b013e3181664e8d |url=}}</ref>
*[[Atopic dermatitis]].
*[[Atopic dermatitis]].
*Contact dermatitis.
*[[Contact dermatitis]].
*Stasis dermatitis.
*Stasis dermatitis.
*[[Seborrheic dermatitis]].
*[[Seborrheic dermatitis]].
Line 355: Line 459:
*Psoriasis vulgaris.
*Psoriasis vulgaris.
*Dermatophyte infection.
*Dermatophyte infection.
*Pityriasis rubra pilaris.
*[[Pityriasis rubra pilaris]].


===Irregular psoriasiform dermatitis===
===Irregular psoriasiform dermatitis===
Line 379: Line 483:
*Lichen sclerosis et atrophicus.
*Lichen sclerosis et atrophicus.
*[[Erythema dyschromicum perstans]] (ashy dermatosis).
*[[Erythema dyschromicum perstans]] (ashy dermatosis).
Super lame mnemonic ''Danny G & SLE'':
*'''D'''ermatomyositis, '''G'''VHD, '''S'''LE, '''L'''ichen sclerosus, '''E'''rythema multiforme.


===Lichenoid interface dermatitides===
===Lichenoid interface dermatitides===
Line 444: Line 551:
*Linear '''I'''gA disease.
*Linear '''I'''gA disease.


==Perivascular inflammation==
==Dermatitides with perivascular inflammation==
===Lymphocytes===
===Lymphocytes===
Lymphocytes (tightly cuffed):<ref name=pmid18418089/>
Lymphocytes (tightly cuffed):<ref name=pmid18418089/>
Line 470: Line 577:
*'''L'''upus erythematosus.
*'''L'''upus erythematosus.
*'''L'''ymphocytic infiltrate of Jessner / tumid lupus erythematosus.
*'''L'''ymphocytic infiltrate of Jessner / tumid lupus erythematosus.
*Polymorphous '''l'''ight eruption.
*[[polymorphous light eruption|Polymorphous '''l'''ight eruption]].
*'''L'''yme disease.
*'''L'''yme disease.


===Neutrophils===
===Neutrophils===
DDx:<ref name=pmid18418089/>
DDx:<ref name=pmid18418089/>
*Cellulitis.
*[[Cellulitis]].
*Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis)
*Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis)


Line 515: Line 622:
*[[Giant cell arteritis]].
*[[Giant cell arteritis]].


==Nodular and diffuse==
==Nodular and diffuse dermatitides==
===Neutrophils===
===Neutrophils===
====With pus (suppurative)====
====With pus (suppurative)====
Line 561: Line 668:


=====Tuberculoid=====
=====Tuberculoid=====
*Tuberculosis.
*[[Tuberculosis]].
*Tertiary [[syphilis]] - usu. abundant plasma cells.
*Tertiary [[syphilis]] - usu. abundant plasma cells.
*Cutaneous leishmaniasis.
*Cutaneous leishmaniasis.
Line 576: Line 683:
*[[Rheumatoid nodule]].
*[[Rheumatoid nodule]].
*[[Necrobiosis lipoidica]].
*[[Necrobiosis lipoidica]].
*Necrobiotic xanthogranuloma.
*[[Necrobiotic xanthogranuloma]].
*[[Churg-Strauss syndrome]].
*[[Churg-Strauss syndrome]].


Latest revision as of 22:18, 5 December 2018

Inflammatory skin disorders, also inflammatory skin diseases, are a significant part of dermatopathology. They lead to trepidation among pathologists that don't see lots of skin. Non-inflammatory skin disease is covered in dermatologic neoplasms and non-malignant skin disease.

Classification

  • Bullous.
  • Interface.
  • Nodular & diffuse.
  • Spongiotic.
  • Vasculitis.
  • Perivascular.
  • Panniculitis.
  • Psoriasiform.

Tabular comparison of inflammatory skin disease (adapted from Brinster[1][2]):

Pattern Key histologic feature Subclassifications Example Image
Bullous large "empty spaces" -subcorneal
-suprabasillar
-subepidermal 		-pemphigus foliaceus
-pemphigus vulgaris
-dermatitis herpetiformis
PV (WC)
Interface inflammation at DE junction -vacuolar (minimal)
-lichenoid (band-like) 		-erythema multiforme, SLE
-lichen planus
VID (WC)
Nodular & diffuse intradermal inflammatory infiltrate - nodular and/or diffuse -neutrophic
-lymphocytic
-plasmic
-eosinophilic
-histocytic 		-follicular occlusion triad, ruptured cyst/follicle
-CTCL, reactive
-plasma cell neoplasm, syphilis
-eosinophilic cellulitis, Kimura disease
-granuloma annulare, sarcoidosis, TB
CTCL (WC)
Spongiotic small empty spaces between keratinocytes - can see squamous bridges (best seen at high power); +/- quasi-microvacuolar appearance -acute
-subacute
-chronic 		-poison ivy
-nummular dermatitis
-atopic dermatitis 		severe (WC), mild (WC)
Vasculitis inflammation of vessel wall/vessel was destruction -small vessel
-medium vessel
-large vessel 		-leukocytoclastic vasculitis
-PAN
-giant cell arteritis
EGPA (WC)
Perivascular inflammation around vessels -neutrophilic
-lymphocytic
-mastocytic
-eosinophilic 		-cellulitis
-viral exanthem, Rx reaction
-mastocytosis
-insect bite, Rx reaction
DPLI (WC)
Panniculitis inflammation of adipose tissue -septal
-lobular 		-erythema nodosum, scleroderma panniculitis
-erythema induratum, infection
Psoriasiform epidermal thickening
and long rete ridges 		-regular
-irregular 		-psoriasis
-lichen simplex chronicus
LSC (WC)

Notes:

  • DE junction = dermal-epidermal junction.
  • The "empty space" in bullous disease in situ is filled with fluid.

Non-specific patterns

Psoriasiform pattern

General

  • Can be subclassified.

DDx:

  • Psoriasis vulgaris (most common).
  • Psoriatic arthritis.
  • Drug-induced.
  • Dermatomycosis (fungal infection).
  • Others.

Microscopic

Features:[3][1]

  • Regular epidermal thickening - as very long rete ridges (described as "test tube-morphology") - key feature.
    • Epidermis between rete ridges thin ("thinning of suprapapillary plate").
  • Parakeratosis.
  • Thin/absent granular layer.
  • Dilated blood vessels in superficial dermis.
  • Neutrophil clusters (Munro microabscess).

Specific diseases

Seborrheic dermatitis

General

  • Very common.

Microscopic

Features:[4]

  • Spongiosis (epidermal edema).
  • Acanthosis (epidermal thickening).
  • "Follicular lipping" = parakeratosis with neutrophils.
  • Perivascular neutrophils and lymphocytes.

Lupus erythematosus

General

Microscopic

Features - classic:

  • Lymphocytic interface dermatitis.[5]
  • Basal layer vacuolization.[6]
  • Intradermal mucin.
  • Thin epidermis.
  • Compact stratum corneum.

DDx:

Images

  • Vacuolar interface dermatitis with dermal mucin - low mag. (WC)

  • Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)

  • Vacuolar interface dermatitis with dermal mucin - high mag. (WC)

  • Vacuolar interface dermatitis with dermal mucin - very high mag. (WC)

Discoid lupus erythematosus

General

Microscopic

Features:[7]

  • Lymphocytic interface dermatitis with basal layer vacuolation and keratinocyte apoptosis.
  • Deep dermal lymphocytes.
  • Basket weave stratum corneum.
  • Dermal mucin.
  • Thick dermal-epidermal basement membrane.

DDx:

Image:

Dermatomyositis

For the muscle manifestations see: Neuromuscular_pathology#Dermatomyositis.

General

  • Complement mediated disease - membrane attack complex.
  • Usually middle age.
  • Associated skin rash is common.
    • May precede or follow muscle pathology.
  • Associated with malignancy in approximately 10% of cases.[8]

Clinical:

  • Jo-1 +ve.

Gross

  • Have lesions on the knuckles - Gottron's papules.

Microsopic

Features:

  • Vacuolar interface dermatitis (lymphocytic inflammation at the dermal-epidermal junction).
  • +/-Loss of rete ridges.

DDx:

  • Lupus.

Lichen planus

Should not be confused with lichen planus-like keratosis.
  • Abbreviated LP.

General

Etiology:

  • Autoimmune disease, T-cell–mediated.[11]

Clinical:[12]

  • 6 Ps: pruritic (itchy), purple, polygonal, planar papules and plaques.

Note:

  • Clinically, lichen planus and lichen sclerosus are similar. The main difference is lichen planus involves mucous membranes.[13]

Gross

  • Wickham striae = white lines/dots.
    • Due to hypergranulosis.

Microscopic

Features:[14][15]

  • Loss of basal cells (stratum basale) -- key feature.
  • Loss of rete ridges/formation of pointed rete ridges "sawtoothing".
  • Interface dermatitis (lymphocytes at dermal-epidermal junction).
  • Hypergranulosis; stratum granulosum thickened (grossly seen as "Wickham stria" = white lines).
  • Hyperkeratosis; stratum corneum thickened.
  • Necrotic basal cell in dermis = colloid bodies = Civatte bodies.[16]
    • Pink bodies approximately the size of a keratinocyte.

Notes:

DDx:

Images

  • Lichen planus - intermed. mag. (WC/Nephron)

  • Lichen planus - low mag. (WC/Nephron)

Stains

  • PAS-D or PAS-F to exclude a fungal infection.

Sign out

FORESKIN, CIRCUMCISION:
- LICHEN PLANUS.

VULVA, LEFT POSTERIOR FOURCHETTE, BIOPSY:
- COMPATIBLE WITH LICHEN PLANUS.

Micro

The sections show skin with a lymphoplasmacytic interface dermatitis, basal cell loss, hypergranulosis, hyperkeratosis, loss of the rete ridges and Civatte bodies.

The epidermis matures to the surface. No significant nuclear atypia is identified.

Fungal organisms are not identified with a PAS-D stain.

Lichen sclerosus

Main article: Lichen sclerosus

Microscopic

Features:[19]

  • Subepithelial fibrosis - key feature.

Psoriasis

General

  • Other considerations:
    • Drug-induced psoriasis.[22]

Clinical

  • Auspitz sign = pin-point bleeding on removal of scale.
  • Koebner phenomenon = lesions form at site of trauma.

Common locations:[20]

  • Knees, elbows, scalp, glans penis.

Microscopic

Features:[20]

  • "Regular" acanthosis + long rete ridges (psoriasiform hyperplasia).
  • Parakeratosis.
  • Dilated vessels in superficial dermis (give rise to Auspitz sign).
  • Spongiform pustules = PMNs in stratum spinosum.
  • PMNs in parakeratotic stratum corneum (Munro microabscess).
  • Thinning of the suprapapillary plate.
    • The epidermis between rete ridges is thinner than in the normal adjacent skin - key feature.

DDx:

Note:

Images

www:

Stains

Sign out

SKIN LESION, LEFT ARM, PUNCH BIOPSY:
- SKIN WITH ACANTHOSIS, HYPERKERATOSIS, FOCAL PARAKERATOSIS, PROMINENT
  DILATED VESSELS IN THE SUPERFICIAL DERMIS, SUPERFICIAL SPONGIFORM PUSTULES.
- MILD NONSPECIFIC PERIVASCULAR INFLAMMATION.
- NEGATIVE FOR FUNGAL ORGANISMS WITH PAS STAINING.

COMMENT:
The findings are compatible with psoriasis.

Micro

The sections show skin with regular psoriasiform change, hyperkeratosis, focal parakeratosis, prominent dilated vessels in the superficial dermis, superficial clusters of intraepidermal neutrophils (spongiform pustules) and thinning of the suprapapillary plate is present. A few perivascular inflammatory cells are present.

There is no epidermal necrosis. Eosinophils are not apparent. The lymphocytes do not have significant atypia.

Lichen striatus

General

Features:[24]

  • Benign, self-limited.

Clinical:

Clinical image:

Microscopic

Features:

  • "Ball and glove" pattern:
    • Rete ridges (glove) surround nexts of lymphocytes (ball).
  • Hyperkeratosis.
  • Parakeratosis.

DDx:

Images:

Lichen aureus

General

  • Rare.

Clinical:[25]

  • Plaques + minimal scale - erythematous/golden.

Microscopic

Features:[25]

  • Lymphocyte-predominant perivascular pattern.
    • May have features suggestive of vacuolar interface pattern.
  • Fibrosis of superficial papillary dermis.

Images:

Granuloma faciale

General

Microscopic

Features:[27]

  • Neutrophilic vasculitis - often subtle:
    • Neutrophils within blood vessel walls.
    • Vessels destruction (fibrinoid necrosis or nuclear dust).
  • Mixed inflammatory superficial dermal infiltrate.
    • Eosinophils, neutrophils, plasma cells, histiocytes.
  • Lesion separated from the (normal) epidermis (Grenz zone).[26]

DDx of chronic fibrosing leukocytoclastic vasculitis:[27]

  • Granuloma faciale.
  • Erythema elevatum diutinum - lacks Grenz zone.
  • Inflammatory pseudotumour.

Image:

Atopic dermatitis

  • AKA atopic eczema, AKA infantile eczema.

General

  • Very common - especially in children.[28]
    • Most children outgrow the condition.

Microscopic

Features:

  • Spongiotic dermatitis.

DDx:

Images

  • Mild spongiotic dermatitis - high mag. (WC)

  • Mild spongiotic dermatitis - very high mag. (WC)

Sweet syndrome

General

  • Uncommon.

Microscopic

Features:

  • Nodular and diffuse pattern - neutrophils predominant - without pus.

DDx rips:

Image:

Granuloma inguinale

Not to be confused with granuloma annulare.
  • Previously known as donovanosis.

General

  • Infection caused by Klebsiella granulomatis - Gram-negative, rod-shaped bacteria.
    • Used to be known as Calymmatobacterium granulomatis.[30]

Location:

Clinical:[31]

  • Sexually transmitted.
  • Nodule or papule developing into a painless ulcer in the inguinal region.
  • No lymphadenopathy (unlike syphilis).

Microscopic

Features:

  • Donovan bodies - key feature:
    • Rod-shaped bodies within histiocytes.

DDx:

Image:

Stains

Pyoderma gangrenosum

Main article: Pyoderma gangrenosum

Necrobiotic xanthogranuloma

  • Abbreviated NXG.
Main article: Necrobiotic xanthogranuloma

DDx for pattern

Spongiotic dermatitides

DDx:[1]

Psoriasiform dermatitides

Regular psoriasiform dermatitis

DDx:[1]

Irregular psoriasiform dermatitis

Interface dermatitides

Vacuolar interface dermatitides

DDx:[1]

Others:[1]

Additional:[32]

  • Phototoxic dermatitis.
  • Acute radiation dermatitis.
  • Erythema multiforme-like drug eruption.
  • Lichen sclerosis et atrophicus.
  • Erythema dyschromicum perstans (ashy dermatosis).

Super lame mnemonic Danny G & SLE:

  • Dermatomyositis, GVHD, SLE, Lichen sclerosus, Erythema multiforme.

Lichenoid interface dermatitides

DDx:[1]

Additional:[32]

Bullous disease

Main article: Bullous disease

Subcorneal bullous disorders

DDx with acantholysis:[1]

DDx without acantholysis:DDx:[1]

Suprabasilar bullous disorders

DDx:[1]

Memory device - PhD + Grover = Pemphigus vulgaris, Hailey-Hailey, Darier, Grover.

Subepidermal bullous disorders

DDx:[1]

Others:

Mnemonic DELPHI:

  • Dermatitis herpetiformis.
  • Epidermolysis bullosa acquisita.
  • Bullous lupus erythematosis.
  • Pemphigoid, bullous.
  • Herpes gestationis - rare autoimmune bullous dermatosis of pregnancy, not related to HSV.[33]
  • Linear IgA disease.

Dermatitides with perivascular inflammation

Lymphocytes

Lymphocytes (tightly cuffed):[1]

  • Infections.
  • Medications.
  • Malignancy.
  • Vitiligo (with absent melanocytes).
  • Scleroderma/morphea.

Lymphocytes & plasma cells +/-eosinophils:

  • Erythema chronicum migrans (Lyme disease).

Lymphocytes (not tightly cuffed):

  • Viral exanthems.
  • Drug eruptions.

Lymphocytes & eosinophils:

  • Drug reaction.
  • Insect bite.
  • Dermatophyte infection.

A simple memory device - 6 Ls:[34]

  • Lymphoma.
  • Pseudolymphoma (cutaneous lymphoid hyperplasia, lymphocytoma cutis).
  • Lupus erythematosus.
  • Lymphocytic infiltrate of Jessner / tumid lupus erythematosus.
  • Polymorphous light eruption.
  • Lyme disease.

Neutrophils

DDx:[1]

  • Cellulitis.
  • Neutrophilic eccrine hidradenitis (idiopathic palmar-plantar hidradenitis)

With eosinophils:

  • Urticaria.

Eosinophils

DDx:[1]

  • Hypersensitivity reaction/drug reaction.
  • Insect bite.
  • Bullous pemphigoid, urticarial.

Mast cells

Vasculitis

Main article: Vasculitides

General DDx:

  • Infection.
  • Autoimmune.
  • Malignancy.
  • Toxic (medications).

Small vessel:

Medium vessel:

Medium vessels often with small vessel involvement:

Large vessel:

Nodular and diffuse dermatitides

Neutrophils

With pus (suppurative)

Neutrophils only:

  • Follicular occlusion triad.
  • Ruptured cyst/follicle.

Neutrophils and eosinophils:

  • Halogenoderma.
  • Blastomycosis-like pyoderma (pyoderma vegetans) - due to bacterial infection, usu. S. aureus.

Without pus

With vasculitis:

Without vasculitis:

Lymphocytes

Plasma cells

Eosinophils

Histiocytes

Granulomatous

Sarcoidal
  • Sarcoidosis - have few lymphoid cells around them; thus called "naked granulomas".[2]
Tuberculoid
Foreign body-type granulomas
Palisaded granumolas

Blue granuloma:

Red granuloma:

See also

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Brinster NK (March 2008). "Dermatopathology for the surgical pathologist: a pattern based approach to the diagnosis of inflammatory skin disorders (part I)". Adv Anat Pathol 15 (2): 76–96. doi:10.1097/PAP.0b013e3181664e8d. PMID 18418089.
  2. ↑ 2.0 2.1 Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
  3. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1191. ISBN 978-1416031215.
  4. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1191. ISBN 978-1416031215.
  5. ↑ JAH. 20 February 2009.
  6. ↑ Crowson AN, Magro CM, Mihm MC (April 2008). "Interface dermatitis". Arch. Pathol. Lab. Med. 132 (4): 652–66. PMID 18384217. http://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282008%29132%5B652%3AID%5D2.0.CO%3B2.
  7. ↑ URL: http://www.dermpedia.org/baby-dermpedia-for-beginners/discoid-lupus-erythematosus. Accessed on: 7 March 2012.
  8. ↑ Chen YJ, Wu CY, Huang YL, Wang CB, Shen JL, Chang YT (2010). "Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan". Arthritis Res. Ther. 12 (2): R70. doi:10.1186/ar2987. PMC 2888225. PMID 20398365. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888225/.
  9. ↑ Teichman, JM.; Sea, J.; Thompson, IM.; Elston, DM. (Jan 2010). "Noninfectious penile lesions.". Am Fam Physician 81 (2): 167-74. PMID 20082512.
  10. ↑ Gupta, R.; Bansal, B.; Singh, S.; Yadav, I.; Gupta, K.; Kudesia, M. (2009). "Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report.". Cases J 2: 9306. doi:10.1186/1757-1626-2-9306. PMID 20062629.
  11. ↑ URL: http://emedicine.medscape.com/article/1078327-overview. Accessed on: 11 September 2010.
  12. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1191. ISBN 978-1416031215.
  13. ↑ McPherson, T.; Cooper, S.. "Vulval lichen sclerosus and lichen planus.". Dermatol Ther 23 (5): 523-32. doi:10.1111/j.1529-8019.2010.01355.x. PMID 20868406.
  14. ↑ URL: http://emedicine.medscape.com/article/1078327-overview. Accessed on: 11 September 2010.
  15. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1192. ISBN 978-1416031215.
  16. ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 604. ISBN 978-1416054542.
  17. ↑ URL: http://www.careforumwales.org/cell-carcinoma/histopathologic-terminology.html. Accessed on: 28 August 2011.
  18. ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 36. ISBN 978-0443066542.
  19. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1065-6. ISBN 0-7216-0187-1.
  20. ↑ 20.0 20.1 20.2 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 603. ISBN 978-1416054542.
  21. ↑ URL: http://medical-dictionary.thefreedictionary.com/spondylosis. Accessed on: 28 August 2011.
  22. ↑ Milavec-Puretić, V.; Mance, M.; Ceović, R.; Lipozenčić, J. (Mar 2011). "Drug induced psoriasis.". Acta Dermatovenerol Croat 19 (1): 39-42. PMID 21489366.
  23. ↑ URL: http://missinglink.ucsf.edu/lm/dermatologyglossary/psoriasis.html. Accessed on: 4 September 2013.
  24. ↑ 24.0 24.1 Taniguchi Abagge, K.; Parolin Marinoni, L.; Giraldi, S.; Carvalho, VO.; de Oliveira Santini, C.; Favre, H.. "Lichen striatus: description of 89 cases in children.". Pediatr Dermatol 21 (4): 440-3. doi:10.1111/j.0736-8046.2004.21403.x. PMID 15283785.
  25. ↑ 25.0 25.1 Hazan, C.; Fangman, B.; Cohen, D. (2007). "Lichen aureus.". Dermatol Online J 13 (1): 23. PMID 17511956.
  26. ↑ 26.0 26.1 URL: http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=1289066309. Accessed on: 23 September 2011.
  27. ↑ 27.0 27.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 198-9. ISBN 978-0443066542.
  28. ↑ URL: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001856/. Accessed on: 28 December 2011.
  29. ↑ URL: http://dermatology.cdlib.org/94/NYU/Apr2002/7.html. Accessed on: 4 January 2012.
  30. ↑ O'Farrell N (December 2002). "Donovanosis". Sex Transm Infect 78 (6): 452–7. PMC 1758360. PMID 12473810. http://sti.bmj.com/cgi/pmidlookup?view=long&pmid=12473810.
  31. ↑ Bezerra, SM.; Jardim, MM.; Silva, VB. (Jun 2011). "Granuloma inguinale (Donovanosis).". An Bras Dermatol 86 (3): 585-6. PMID 21738983.
  32. ↑ 32.0 32.1 Alsaad, KO.; Ghazarian, D. (Dec 2005). "My approach to superficial inflammatory dermatoses.". J Clin Pathol 58 (12): 1233-41. doi:10.1136/jcp.2005.027151. PMC 1770784. PMID 16311340. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770784/.
  33. ↑ URL: http://emedicine.medscape.com/article/1063499-overview. Accessed on: 23 September 2011.
  34. ↑ URL: http://www.dermpathmd.com/mnemonics/mnemonics_dermatopathology.htm. Accessed on: 23 September 2011.

External links

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