Angiolymphoid hyperplasia with eosinophilia

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Angiolymphoid hyperplasia with eosinophilia, abbreviated ALHE, is a rare skin pathology. It is also known as epithelioid hemangioma.[1]


  • Similar to Kimura disease.[2]
  • Very rare.
  • Typical patient: Caucasian, woman.[2]
  • Hypothesized to be a precursor to lymphoma.[3]


  • Location: usually head and neck.[3]
  • Skin papules or nodules.[4]




  • Marked vascular proliferation.
  • Few lymphoid follicles.
  • Moderate eosinophils.


  • No fibrosis.



See also


  1. Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 548. ISBN 978-0443066542.
  2. 2.0 2.1 2.2 Zaraa, I.; Mlika, M.; Chouk, S.; Chelly, I.; Mokni, M.; Zitouna, M.; Osman, AB. (2011). "Angiolymphoid hyperplasia with eosinophilia: a study of 7 cases.". Dermatol Online J 17 (2): 1. PMID 21382284.
  3. 3.0 3.1 Gonzalez-Cuyar, LF.; Tavora, F.; Zhao, XF.; Wang, G.; Auerbach, A.; Aguilera, N.; Burke, AP. (2008). "Angiolymphoid hyperplasia with eosinophilia developing in a patient with history of peripheral T-cell lymphoma: evidence for multicentric T-cell lymphoproliferative process.". Diagn Pathol 3: 22. doi:10.1186/1746-1596-3-22. PMID 18510751.
  4. Bartralot, R.; Garcia-Patos, V.; Hueto, J.; Huguet, P.; Raspall, G.; Castells, A. (Apr 1996). "Angiolymphoid hyperplasia with eosinophilia affecting the oral mucosa: report of a case and a review of the literature.". Br J Dermatol 134 (4): 744-8. PMID 8733384.