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Synaptophysin staining in Atypical carcinoid.

Synaptophysin is the principal structural element of the walls of synaptic vesicles and thus a neuroendocrine marker.

Normal tissues

  • Note: resists autolytic degradation (can be used 5 days post mortem).
  • Marker of late onset (neuronal maturation).

Positive staining

  • Cerebral cortex
  • Hippocampus
  • Corpus striatum,
  • Globus pallidus
  • Substantia nigra
  • Cerebellum system
  • Olfactory bulb
  • Pineal gland
  • Adrenal gland
  • Langerhans islets


Negative staining

See also