Neurocytoma

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Neurocytoma is a rare neuropathology tumour.

General

  • Rare.

Microscopic

Features:[1]

  • Pineocytomatous/neurocytic rosette = irregular rosette with a large meshwork of fibers (neuropil) at the centre.[2]
    • Similar to Homer-Wright rosette.
  • Monomorphic cells with round nuclei and speckled chromatin.
  • Perinuclear clearing.
  • Ganglion cell differentiation.
  • Well-defined cell borders.
  • Hyalinized vessels.
  • Necrosis absent.

IHC

  • MIB-1: Usu. low.
  • Synapthophysin +ve.


DDx:


Images

www:

IHC

  • Synaptophysin +ve.
    • Most glial tumour -ve.[3]

Molecular

  • FGFR1-TACC1 fusions common.[4]

See also

References

  1. URL: http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm. Accessed on: 12 October 2011.
  2. Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  3. URL: http://path.upmc.edu/cases/case383/dx.html. Accessed on: 15 January 2012.
  4. Sievers, P.; Stichel, D.; Schrimpf, D.; Sahm, F.; Koelsche, C.; Reuss, DE.; Wefers, AK.; Reinhardt, A. et al. (Jul 2018). "FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.". Acta Neuropathol. doi:10.1007/s00401-018-1882-3. PMID 29978331.