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==Unusually MMR loss== | ==Unusually MMR loss== | ||
https://pmc.ncbi.nlm.nih.gov/articles/PMC8860743/ - isolated MSH6 and isolated PMS2 are the most common of the uncommon loss patterns | https://pmc.ncbi.nlm.nih.gov/articles/PMC8860743/ - isolated MSH6 and isolated PMS2 are the most common of the uncommon loss patterns | ||
== Algorithm == | |||
MLH1/PMS2 loss --> BRAF testing and MLH1 hypermethylation testing | |||
https://www.mayocliniclabs.com/-/media/it-mmfiles/Special-Instructions/C/2/7/Lynch_Syndrome_Testing_Algorithm |
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