Sex cord-stromal tumours
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Sex cord-stromal tumours (abbreviated SCSTs) are a group of tumours found in the testis and ovary that arise from the cells that support the germ cells.
File:Sex cord tumour with annular tubules - 2 - very high mag.jpg
Sex cord tumour with annular tubules (SCTAT), a type of sex cord stromal tumour. H&E stain.
They are typically benign, but may be malignant.
Some tumours classically found in the testis are also found in the ovary.
Testicular
- Leydig cell tumour.
- Sertoli cell tumour.
- Primary signet ring stromal tumour.[1]
Ovarian
Arise from gonadal stroma:
Others:
- Unclassified gonadal stromal tumour.[3]
- Microcystic stromal tumour of the ovary.
Mixed
IHC
- Steroidogenic factor 1 (SF1) +ve.[4]
- Calretinin +ve.
- Inhibin A +ve.
- SALL4 -ve.
- Positive in (most) germ cell tumours.
- FH -ve/+ve.
- A fumarate hydratase-deficient testicular sex cord-stromal tumour has been proposed.[5]
See also
References
- ↑ Michalova K, Michal M, Kazakov DV, Sedivcova M, Hes O, Hadravsky L, Agaimy A, Tretiakova M, Bacchi C, Hartmann A, Kuroda N, Bulimbasic S, Coric M, Antic T, Michal M (September 2017). "Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm". Hum Pathol 67: 85–93. doi:10.1016/j.humpath.2017.07.010. PMID 28739499.
- ↑ 2.0 2.1 Koulouris, CR.; Penson, RT. (Apr 2009). "Ovarian stromal and germ cell tumors.". Semin Oncol 36 (2): 126-36. doi:10.1053/j.seminoncol.2008.12.004. PMID 19332247.
- ↑ Sironi, M.; Santangelo, M.; Pasquinelli, G.; Spinelli, M. (Feb 2001). "[Benign unclassified tumor of the gonadal stroma: importance of alpha-inhibin expression].". Pathologica 93 (1): 50-6. PMID 11294020.
- ↑ Satariano M, Losinski E, Lane J, Wegryn J (September 2023). "Adult-type granulosa cell tumor of the testis: A case report and review of the literature". Urol Case Rep 50: 102532. doi:10.1016/j.eucr.2023.102532. PMC 10445446. PMID 37621390. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445446/.
- ↑ "Fumarate hydratase-deficient testicular sex cord-stromal tumour (FH-TSCST): proposal for reclassification of a subset of Leydig cell tumours with distinct molecular and clinicopathologic features". Histopathology 82 (4): 646–647. March 2023. doi:10.1111/his.14859. PMID 36592067.