Sertoli cell tumour

Sertoli cell tumour
Diagnosis in short
Sertoli cell tumour. H&E stain.
LM	groups of cells in cords or trabeculae, cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin
LM DDx	granulosa cell tumour, epithelioid adenomatoid tumour, sertoli cell nodule, Sertoli-Leydig tumour
IHC	SF-1 +ve, alpha-inhibin +ve, calretinin +ve/-ve,
Site	testis, ovary
Syndromes	Peutz-Jeghers syndrome, Carney complex
Signs	testicular mass
Prevalence	uncommon

Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis. It is occasionally seen in women.

General

• Arises from Sertoli cells (AKA nurse cells).
• Occasionally seen in women.

May be seen in several syndrome - esp. if there is calcification:

• Carney complex.
• Peutz-Jeghers syndrome.

Microscopic

Features:

• Groups of cells in cords or trabeculae (beam-like arrangement).
• Cells have:
  • Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
  • Slightly irregular nucleoli.
  • Granular irregular appearing chromatin.

Negatives:

• Mitoses are rare.
• No significant nuclear atypia.

DDx:

• Granulosa cell tumour - may be very similar. Often has nuclear grooves.
• Epithelioid adenomatoid tumour.
• Sertoli cell nodule.
• Sertoli-Leydig tumour - esp. in ovary.

Images

• 

  Sertoli cell tumour - high mag. (WC)

• 

  Sertoli cell tumour - low mag. (WC)

www:

• Sertoli cell tumour with calcification in Carney complex - several images (upmc.edu).

IHC

• Alpha-inhibin +ve (~95% of cases).
• Calretinin +ve (~55% of cases).
• Beta-catenin +ve (nuclear).
  • Negative beta-catenin should make one consider other diagnoses.^{[citation needed]}
  • May be negative in malignant sertoli cell tumours.
• SF-1 +ve.
  • Germ cell tumours -ve.

Others:

• WT-1 +ve.

See also

• Leydig cell tumour.
• Sertoli-Leydig tumour.
• Sex cord-stromal tumours
• Testis.