Secretory carcinoma of the breast

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Secretory carcinoma of the breast
Diagnosis in short
LM DDx lactational change
IHC ER -ve, PR -ve, HER2 -ve, alpha-lactalbumin +ve, S-100 +ve, polyclonal CEA +ve
Molecular ETV6-NTRK3
Grossing notes breast grossing
Staging breast cancer staging
Site breast - see invasive breast cancer

Prevalence rare
Prognosis favourable

Secretory carcinoma of the breast is an uncommon form of invasive breast cancer that has an appearance similar to breast with lactational changes.

It is also known as secretory breast carcinoma (abbreviated SBC) and breast secretory carcinoma.


  • Favourable prognosis.[1]
  • Children and adults.



  • Abundant cytoplasm with fine vacuolation - clear/pale or amphophilic.
  • Mitoses - uncommon.
  • Nucleoli - rare.
  • Architecture: solid, papillary, cribriform or microcystic.




Triple negative (ER -ve, PR -ve, HER2 -ve).[1]


  • Alpha-lactalbumin +ve.
  • S-100 protein +ve.
  • Polyclonal CEA +ve.

Molecular pathology

Characteristic translocation:[1]


See also


  1. 1.0 1.1 1.2 Vasudev, P.; Onuma, K. (Dec 2011). "Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression.". Arch Pathol Lab Med 135 (12): 1606-10. doi:10.5858/arpa.2010-0351-RS. PMID 22129193.
  2. Laé, M.; Fréneaux, P.; Sastre-Garau, X.; Chouchane, O.; Sigal-Zafrani, B.; Vincent-Salomon, A. (Feb 2009). "Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum.". Mod Pathol 22 (2): 291-8. doi:10.1038/modpathol.2008.184. PMID 19011601.
  3. Vesoulis, Z.; Kashkari, S.. "Fine needle aspiration of secretory breast carcinoma resembling lactational changes. A case report.". Acta Cytol 42 (4): 1032-6. PMID 9684599.
  4. Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.