Mammary analogue secretory carcinoma

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Mammary analogue secretory carcinoma
Diagnosis in short

Mammary analogue secretory carcinoma. H&E stain. (WC/NormanDy)

LM large cells with abundant cytoplasm, small nuclei, +/-lymphocytic infiltrate, solid and microcystic growth pattern
LM DDx acinic cell carcinoma, mucoepidermoid carcinoma
Stains PAS +ve
IHC S-100 +ve, mammaglobin +ve, vimentin +ve
Molecular ETV6-NTRK3 fusion gene
Site salivary gland - usually parotid

Prevalence rare
Clin. DDx other salivary gland tumours

Mammary analogue secretory carcinoma, abbreviated MASC, is a newly described malignant salivary gland tumour.[1]

General

  • Microscopic appearance similar to secretory breast carcinoma.[2]
  • Rare - 21 cases in the world literature as of 2012.[1]
  • Original paper described it only in adults.[2]
    • Has been described in a pediatric patient.[3]

Gross

Microscopic

Features:

  • Large cells with abundant cytoplasm.
  • Small nuclei.
  • +/-Lymphocytic infiltrate.
  • Solid and microcystic growth pattern.
  • +/-Cystic changes lined by hobnail cells - useful feature.

DDx:

Images

www:

Stains

Features:[2]

IHC

Features:[2]

  • S-100 +ve.[1]
  • Mammaglobin +ve.
  • Vimentin +ve.

Others:

  • p63 -ve.
    • Unusual in mucoepidermoid carcinoma.
  • HMWCK -ve.
  • GATA3 +ve.

Panel:

  • S-100, mammaglobin, p63, HMWCK.

Images

Molecular

  • t(12;15)(p13;q25).

Note:

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
  2. 2.0 2.1 2.2 2.3 2.4 Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.
  3. Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.