Lymphocytic mastitis
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| Lymphocytic mastitis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | lymphocytic infiltrates (breast lobules, perivascular), enlarged stromal fibroblasts, stromal collagen with keloid-like changes. |
| LM DDx | lymphoma (small cell), diabetic mastopathy (need history) |
| IHC | CD20 > CD3, CD43 -ve |
| Molecular | negative for clonality |
| Site | breast |
|
| |
| Associated Dx | +/-diabetes mellitus (known as diabetic mastopathy) |
| Signs | +/-tenderness |
| Prevalence | rare |
| Prognosis | benign |
| Clin. DDx | breast tumour - possibly malignant |
| Treatment | +/-excision |
Lymphocytic mastitis is a rare pathology of the breast. If the individual has diabetes mellitus (DM) it is called diabetic mastopathy.[1]
General
- Typically in long-standing diabetes mellitus.[2][3]
- Rare -- less the 1% of breast lesions, though may be seen in up 13% of individuals with long-standing (insulin-dependent) diabetes mellitus.[4]
Clinical:[2]
- +/-Tenderness.
- May mimic malignancy clinically.
- May be managed with follow-up if diabetic.[5]
Microscopic
Features:[6]
- Lymphocytic infiltrates - key feature:
- Lobules.
- Perivascular.
- Enlarged stromal fibroblasts.
- Stromal collagen with keloid-like changes.
DDx:
- Diabetic mastopathy - if individual has diabetes.
- Primary lymphoma of the breast.
Images
www:
- Lymphocytic mastitis - low mag. (webpathology.com).
- Lymphocytic mastitis - high mag. (webpathology.com).
- Lymphocytic mastitis (nih.gov).[2]
- Diabetic mastopathy (nih.gov).[5]
IHC
- B cell predominant (CD20 > CD3).[1]
- B cells CD43 -ve.
Molecular
- Negative clonality studies.
Sign out
- Lymphocytic mastitis if no history of diabetes mellitus.
- Diabetic mastopathy if there is a well-documented history of diabetes mellitus.
See also
References
- ↑ 1.0 1.1 Valdez, R.; Thorson, J.; Finn, WG.; Schnitzer, B.; Kleer, CG. (Mar 2003). "Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases.". Mod Pathol 16 (3): 223-8. doi:10.1097/01.MP.0000056627.21128.74. PMID 12640102.
- ↑ 2.0 2.1 2.2 Alhabshi, SM.; Rahmat, K.; Westerhout, CJ.; Md Latar, NH.; Chandran, PA.; Aziz, S. (May 2013). "Lymphocytic mastitis mimicking breast carcinoma, radiology and pathology correlation: review of two cases.". Malays J Med Sci 20 (3): 83-7. PMID 23966831.
- ↑ Bayer, U.; Horn, LC.; Schulz, HG. (Feb 1998). "Bilateral, tumorlike diabetic mastopathy-progression and regression of the disease during 5-year follow up.". Eur J Radiol 26 (3): 248-53. PMID 9587750.
- ↑ Hunfeld, KP.; Bässler, R. (Jul 1997). "Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases.". Gen Diagn Pathol 143 (1): 49-58. PMID 9269908.
- ↑ 5.0 5.1 Dilaveri, CA.; Mac Bride, MB.; Sandhu, NP.; Neal, L.; Ghosh, K.; Wahner-Roedler, DL. (2012). "Breast manifestations of systemic diseases.". Int J Womens Health 4: 35-43. doi:10.2147/IJWH.S27624. PMID 22371658.
- ↑ URL: http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html. Accessed on: 28 November 2010.