ROS1-rearranged non-small cell lung carcinoma

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Micrograph showing a ROS1-positive adenocarcinoma of the lung. ROS1 immunostain.

ROS1-rearranged non-small cell lung carcinoma is a subtype of non-small cell lung carcinoma that can be treated with ALK inhibitors.[1]

General

Microscopic

Features:

Note:

  • Most common pattern varies by specimen type:[4]
    • Biopsy specimens: solid pattern most common.
    • Resection specimens: acinar pattern most common.

Images

IHC

  • ROS1 +ve.

Images

Molecular

  • ROS1 rearrangements can be demonstrated with dual-colour break apart FISH probes.[5]

See also

References

  1. Shaw, AT.; Ou, SH.; Bang, YJ.; Camidge, DR.; Solomon, BJ.; Salgia, R.; Riely, GJ.; Varella-Garcia, M. et al. (Nov 2014). "Crizotinib in ROS1-rearranged non-small-cell lung cancer.". N Engl J Med 371 (21): 1963-71. doi:10.1056/NEJMoa1406766. PMID 25264305.
  2. Patil T, Simons E, Mushtaq R, Pacheco JM, Doebele RC, Bowles DW (October 2019). "Targeted therapies for ROS1-rearranged non-small cell lung cancer". Drugs Today 55 (10): 641–652. doi:10.1358/dot.2019.55.10.3030646. PMID 31720561.
  3. Shaw AT, Riely GJ, Bang YJ, Kim DW, Camidge DR, Solomon BJ, Varella-Garcia M, Iafrate AJ, Shapiro GI, Usari T, Wang SC, Wilner KD, Clark JW, Ou SI (July 2019). "Crizotinib in ROS1-rearranged advanced non-small-cell lung cancer (NSCLC): updated results, including overall survival, from PROFILE 1001". Ann. Oncol. 30 (7): 1121–1126. doi:10.1093/annonc/mdz131. PMC 6637370. PMID 30980071. //www.ncbi.nlm.nih.gov/pmc/articles/PMC6637370/.
  4. 4.0 4.1 Zhou J, Zhao J, Zheng J, Kong M, Sun K, Wang B, Chen X, Ding W, Zhou J (2016). "A Prediction Model for ROS1-Rearranged Lung Adenocarcinomas based on Histologic Features". PLoS ONE 11 (9): e0161861. doi:10.1371/journal.pone.0161861. PMC 5029801. PMID 27648828. //www.ncbi.nlm.nih.gov/pmc/articles/PMC5029801/.
  5. Bubendorf L, Büttner R, Al-Dayel F, Dietel M, Elmberger G, Kerr K, López-Ríos F, Marchetti A, Öz B, Pauwels P, Penault-Llorca F, Rossi G, Ryška A, Thunnissen E (November 2016). "Testing for ROS1 in non-small cell lung cancer: a review with recommendations". Virchows Arch. 469 (5): 489–503. doi:10.1007/s00428-016-2000-3. PMC 5082594. PMID 27535289. //www.ncbi.nlm.nih.gov/pmc/articles/PMC5082594/.