Lung carcinoma with EGFR mutation

From Libre Pathology
Jump to navigation Jump to search

Lung carcinoma with EGFR mutation is a molecular subtype of lung carcinoma. Morphologically, these tumours are typically adenocarcinomas.




Varies significantly by population:[3]

Population Prevalence Category
Europe 14% Geographic
China 38% Geographic
Females 44% Patient characteristics
Males 24% Patient characteristics
Non-smokers 49% Patient characteristics
Smokers or past smokers 22% Patient characteristics
Adenocarcinoma 38% Pathology
Non-adenocarcinoma 12% Pathology

Sign out

Lung core biopsy, left lower lobe:
	- EGFR mutation POSITIVE, ALK rearrangement NEGATIVE 

See also


  1. Gainor, JF.; Varghese, AM.; Ou, SH.; Kabraji, S.; Awad, MM.; Katayama, R.; Pawlak, A.; Mino-Kenudson, M. et al. (Aug 2013). "ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer.". Clin Cancer Res 19 (15): 4273-81. doi:10.1158/1078-0432.CCR-13-0318. PMID 23729361.
  2. da Cunha Santos, G.; Shepherd, FA.; Tsao, MS. (2011). "EGFR mutations and lung cancer.". Annu Rev Pathol 6: 49-69. doi:10.1146/annurev-pathol-011110-130206. PMID 20887192.
  3. Zhang, YL.; Yuan, JQ.; Wang, KF.; Fu, XH.; Han, XR.; Threapleton, D.; Yang, ZY.; Mao, C. et al. (Nov 2016). "The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis.". Oncotarget 7 (48): 78985-78993. doi:10.18632/oncotarget.12587. PMID 27738317.