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Immunostain in short

Ki-67 staining in an anaplastic astrocytoma.
Use typical carcinoid versus atypical carcinoid), grading (gastrointestinal neuroendocrine tumours)
Normal staining pattern nuclear staining, occasionally membranous pattern (pneumocytoma, hyalinizing trabecular tumour)

Ki-67 is a very commonly used immunostain that is reflective of proliferative activity.

MIB1 redirects here; it is a commonly used antibody against Ki-67.


  • Marker of proliferation.
  • Usually nuclear staining.

Membranous staining pattern

Ki-67 showing a membranous pattern in pneumocytoma.

See also


  1. Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.
  2. Leonardo, E.; Volante, M.; Barbareschi, M.; Cavazza, A.; Dei Tos, AP.; Bussolati, G.; Papotti, M. (Jun 2007). "Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?". Appl Immunohistochem Mol Morphol 15 (2): 220-3. doi:10.1097/01.pai.0000213122.66096.f0. PMID 17525638.